Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313365716> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4313365716 endingPage "189.11" @default.
- W4313365716 startingPage "189.11" @default.
- W4313365716 abstract "Abstract CD8+ T cells play a critical role in adaptive immunity by maintaining the ability to differentiate into CD8+ memory T cells, which provide the basis of protective immunity. During an intracellular infection, CD8+ T cells pass through several characteristic phases before becoming mature memory cells. Initial antigen stimulation causes naïve CD8+ T cells to clonally expand and differentiate into short-lived effector cells (SLECs). Subsequently, SLECs undergo a contraction phase to give rise to memory precursor effector cells (MPECs); 5–10% of the MPECs survive the initial contraction phase and further develop into CD8+ memory T cells. We have shown that the non-receptor tyrosine kinase Itk, which regulates TCR signal strength, can significantly suppress CD8+ memory T cell development. We hypothesize that TCR signal strength, regulated by Itk, intersects with antigen affinity to modulate the development of SLECs and MPECs, leading to an increased proportion of memory CD8+ T cells. Utilizing Itk deficient OT-1 TCR transgenic mice, which carry CD8+ T cells specific for the Ovalbumin protein, an adoptive transfer model was established to exam the influence of TCR signal strength and antigen affinity in the development of CD8+ memory T cells. Our findings suggest that TCR signal strength and affinity independently contribute to CD8+ memory T cell development. Our data reveals that reducing both antigen affinity and TCR signal strength leads to enhanced and accelerated antigen-mediated proliferation and development of memory cells, and enhanced secondary expansion of these memory cells. In sum, our data suggests that TCR signal strength and antigen affinity are independent parameters that may be used to tune vaccine development." @default.
- W4313365716 created "2023-01-06" @default.
- W4313365716 creator A5000896541 @default.
- W4313365716 creator A5003707016 @default.
- W4313365716 creator A5079102842 @default.
- W4313365716 date "2019-05-01" @default.
- W4313365716 modified "2023-09-27" @default.
- W4313365716 title "TCR signal strength and antigen affinity independently modulate CD8+ memory T cell development" @default.
- W4313365716 doi "https://doi.org/10.4049/jimmunol.202.supp.189.11" @default.
- W4313365716 hasPublicationYear "2019" @default.
- W4313365716 type Work @default.
- W4313365716 citedByCount "0" @default.
- W4313365716 crossrefType "journal-article" @default.
- W4313365716 hasAuthorship W4313365716A5000896541 @default.
- W4313365716 hasAuthorship W4313365716A5003707016 @default.
- W4313365716 hasAuthorship W4313365716A5079102842 @default.
- W4313365716 hasConcept C147483822 @default.
- W4313365716 hasConcept C154317977 @default.
- W4313365716 hasConcept C167672396 @default.
- W4313365716 hasConcept C19317047 @default.
- W4313365716 hasConcept C202751555 @default.
- W4313365716 hasConcept C203014093 @default.
- W4313365716 hasConcept C2776090121 @default.
- W4313365716 hasConcept C55493867 @default.
- W4313365716 hasConcept C86803240 @default.
- W4313365716 hasConcept C8891405 @default.
- W4313365716 hasConcept C90375314 @default.
- W4313365716 hasConcept C95444343 @default.
- W4313365716 hasConceptScore W4313365716C147483822 @default.
- W4313365716 hasConceptScore W4313365716C154317977 @default.
- W4313365716 hasConceptScore W4313365716C167672396 @default.
- W4313365716 hasConceptScore W4313365716C19317047 @default.
- W4313365716 hasConceptScore W4313365716C202751555 @default.
- W4313365716 hasConceptScore W4313365716C203014093 @default.
- W4313365716 hasConceptScore W4313365716C2776090121 @default.
- W4313365716 hasConceptScore W4313365716C55493867 @default.
- W4313365716 hasConceptScore W4313365716C86803240 @default.
- W4313365716 hasConceptScore W4313365716C8891405 @default.
- W4313365716 hasConceptScore W4313365716C90375314 @default.
- W4313365716 hasConceptScore W4313365716C95444343 @default.
- W4313365716 hasIssue "1_Supplement" @default.
- W4313365716 hasLocation W43133657161 @default.
- W4313365716 hasOpenAccess W4313365716 @default.
- W4313365716 hasPrimaryLocation W43133657161 @default.
- W4313365716 hasRelatedWork W1978878186 @default.
- W4313365716 hasRelatedWork W2020540857 @default.
- W4313365716 hasRelatedWork W2045231844 @default.
- W4313365716 hasRelatedWork W2058769338 @default.
- W4313365716 hasRelatedWork W2063492259 @default.
- W4313365716 hasRelatedWork W2106875608 @default.
- W4313365716 hasRelatedWork W2107792671 @default.
- W4313365716 hasRelatedWork W2134262970 @default.
- W4313365716 hasRelatedWork W2287738525 @default.
- W4313365716 hasRelatedWork W2480226770 @default.
- W4313365716 hasVolume "202" @default.
- W4313365716 isParatext "false" @default.
- W4313365716 isRetracted "false" @default.
- W4313365716 workType "article" @default.