Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313365748> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4313365748 endingPage "72.4" @default.
- W4313365748 startingPage "72.4" @default.
- W4313365748 abstract "Abstract HIV sequence diversity and the propensity of eliciting immunodominant responses targeting non-essential variable regions are hurdles in the development of an effective AIDS vaccine. We developed a DNA vaccine comprising conserved elements (CE) of Gag and Env. Macaques (RM) received the CE DNA prime/CE+full-length DNA co-delivery booster vaccine regimen via intramuscular injection followed by electroporation. Priming vaccination with CE DNA is critical to efficiently overcome the dominance imposed by Gag and Env variable regions. CE vaccine induced broad, potent and durable cytotoxic T cell responses targeting conserved segments. Gag CE-specific T cells showed robust anamnestic responses upon infection with SIVmac239 which led to the identification of CE-specific cytotoxic lymphocytes able to recognize several CE epitopes presented on SIV infected cells in vivo. The T cell responses induced by the HIV Env CE immunogen were also recalled upon SIV infection, leading to the identification of two cross-reactive epitopes between HIV and SIV Env. These data demonstrate that the CE DNA vaccines changed the normal immunodominance patterns, eliciting immune responses that included subdominant, highly conserved epitopes. These vaccine regimens augment cytotoxic T cell responses to highly conserved epitopes in the viral proteome and maximize response breadth. The HIV Gag CE vaccine regimen is evaluated for prevention and immunotherapy in clinical trials (HVTN119 and ACTG 5369)." @default.
- W4313365748 created "2023-01-06" @default.
- W4313365748 creator A5019312080 @default.
- W4313365748 creator A5028336562 @default.
- W4313365748 creator A5030799310 @default.
- W4313365748 creator A5055653289 @default.
- W4313365748 creator A5066261446 @default.
- W4313365748 creator A5069687616 @default.
- W4313365748 creator A5078830084 @default.
- W4313365748 date "2019-05-01" @default.
- W4313365748 modified "2023-09-26" @default.
- W4313365748 title "Novel HIV DNA vaccine changes the immune hierarchy and elicits broad cytotoxic T cell responses targeting subdominant viral epitopes" @default.
- W4313365748 doi "https://doi.org/10.4049/jimmunol.202.supp.72.4" @default.
- W4313365748 hasPublicationYear "2019" @default.
- W4313365748 type Work @default.
- W4313365748 citedByCount "0" @default.
- W4313365748 crossrefType "journal-article" @default.
- W4313365748 hasAuthorship W4313365748A5019312080 @default.
- W4313365748 hasAuthorship W4313365748A5028336562 @default.
- W4313365748 hasAuthorship W4313365748A5030799310 @default.
- W4313365748 hasAuthorship W4313365748A5055653289 @default.
- W4313365748 hasAuthorship W4313365748A5066261446 @default.
- W4313365748 hasAuthorship W4313365748A5069687616 @default.
- W4313365748 hasAuthorship W4313365748A5078830084 @default.
- W4313365748 hasConcept C100701293 @default.
- W4313365748 hasConcept C154317977 @default.
- W4313365748 hasConcept C159047783 @default.
- W4313365748 hasConcept C159654299 @default.
- W4313365748 hasConcept C167508917 @default.
- W4313365748 hasConcept C195616568 @default.
- W4313365748 hasConcept C202751555 @default.
- W4313365748 hasConcept C203014093 @default.
- W4313365748 hasConcept C22070199 @default.
- W4313365748 hasConcept C2776090121 @default.
- W4313365748 hasConcept C2776525413 @default.
- W4313365748 hasConcept C2778190748 @default.
- W4313365748 hasConcept C2778886782 @default.
- W4313365748 hasConcept C2780195530 @default.
- W4313365748 hasConcept C2780801004 @default.
- W4313365748 hasConcept C2909828532 @default.
- W4313365748 hasConcept C54355233 @default.
- W4313365748 hasConcept C59822182 @default.
- W4313365748 hasConcept C81444415 @default.
- W4313365748 hasConcept C86803240 @default.
- W4313365748 hasConcept C8891405 @default.
- W4313365748 hasConceptScore W4313365748C100701293 @default.
- W4313365748 hasConceptScore W4313365748C154317977 @default.
- W4313365748 hasConceptScore W4313365748C159047783 @default.
- W4313365748 hasConceptScore W4313365748C159654299 @default.
- W4313365748 hasConceptScore W4313365748C167508917 @default.
- W4313365748 hasConceptScore W4313365748C195616568 @default.
- W4313365748 hasConceptScore W4313365748C202751555 @default.
- W4313365748 hasConceptScore W4313365748C203014093 @default.
- W4313365748 hasConceptScore W4313365748C22070199 @default.
- W4313365748 hasConceptScore W4313365748C2776090121 @default.
- W4313365748 hasConceptScore W4313365748C2776525413 @default.
- W4313365748 hasConceptScore W4313365748C2778190748 @default.
- W4313365748 hasConceptScore W4313365748C2778886782 @default.
- W4313365748 hasConceptScore W4313365748C2780195530 @default.
- W4313365748 hasConceptScore W4313365748C2780801004 @default.
- W4313365748 hasConceptScore W4313365748C2909828532 @default.
- W4313365748 hasConceptScore W4313365748C54355233 @default.
- W4313365748 hasConceptScore W4313365748C59822182 @default.
- W4313365748 hasConceptScore W4313365748C81444415 @default.
- W4313365748 hasConceptScore W4313365748C86803240 @default.
- W4313365748 hasConceptScore W4313365748C8891405 @default.
- W4313365748 hasIssue "1_Supplement" @default.
- W4313365748 hasLocation W43133657481 @default.
- W4313365748 hasOpenAccess W4313365748 @default.
- W4313365748 hasPrimaryLocation W43133657481 @default.
- W4313365748 hasRelatedWork W1594151399 @default.
- W4313365748 hasRelatedWork W1678741069 @default.
- W4313365748 hasRelatedWork W1906357440 @default.
- W4313365748 hasRelatedWork W2019214329 @default.
- W4313365748 hasRelatedWork W2143941734 @default.
- W4313365748 hasRelatedWork W2166087046 @default.
- W4313365748 hasRelatedWork W2797923168 @default.
- W4313365748 hasRelatedWork W2811086536 @default.
- W4313365748 hasRelatedWork W4313365748 @default.
- W4313365748 hasRelatedWork W4313373361 @default.
- W4313365748 hasVolume "202" @default.
- W4313365748 isParatext "false" @default.
- W4313365748 isRetracted "false" @default.
- W4313365748 workType "article" @default.