Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313365750> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4313365750 endingPage "197.15" @default.
- W4313365750 startingPage "197.15" @default.
- W4313365750 abstract "Abstract Progressive Multifocal Leukoencephalopathy (PML) is a fatal demyelinating brain disease caused by JC polyomavirus (JCPyV). Most individuals are asymptomatically infected with JCPyV, but those with immunological perturbations are at risk of developing PML. PML pathogenesis is closely linked with the emergence of JCPyV mutants bearing mutations in regions of the VP1 major capsid protein that bind host cell receptors; these mutations may mediate immune escape or result in altered cell tropism/neurovirulence. A frequent PML mutation in VP1, S269F, is located in the receptor-binding pocket of the virus capsid. To investigate the effects of the S269F mutation on viral infection and the immune response, we utilized mouse polyomavirus (MuPyV) as a natural pathogen-host model of JCPyV infection. We generated a MuPyV mutant containing a V296F substitution in VP1, which maps to the S269F mutation in JCPyV, to ask whether this mutation on immune evasion and host cell tropism. The MuPyV DNA genome incorporates cellular histones; thus we generated infectious fluorescent MuPyV by infecting a host cell line expressing an H2B histone-GFP protein. Using this fluorescently-labeled virus, we determined that a VP1 monoclonal antibody (mAb), which neutralizes wild type virus, binds the V296F mutant, but is unable to block viral attachment and infection. We are currently generating cryo-EM reconstructions to visualize the interaction of this mAb with the wild type and V296F mutant viruses. This data suggests that this PML-synonymous mutation in MuPyV may allow escape from antiviral humoral immunity." @default.
- W4313365750 created "2023-01-06" @default.
- W4313365750 creator A5011453313 @default.
- W4313365750 creator A5041207784 @default.
- W4313365750 creator A5043138474 @default.
- W4313365750 creator A5055388797 @default.
- W4313365750 creator A5072256301 @default.
- W4313365750 date "2019-05-01" @default.
- W4313365750 modified "2023-09-26" @default.
- W4313365750 title "A PML-Synonymous Mutation in MuPyV Results in Viral Escape from a Neutralizing Monoclonal Antibody" @default.
- W4313365750 doi "https://doi.org/10.4049/jimmunol.202.supp.197.15" @default.
- W4313365750 hasPublicationYear "2019" @default.
- W4313365750 type Work @default.
- W4313365750 citedByCount "0" @default.
- W4313365750 crossrefType "journal-article" @default.
- W4313365750 hasAuthorship W4313365750A5011453313 @default.
- W4313365750 hasAuthorship W4313365750A5041207784 @default.
- W4313365750 hasAuthorship W4313365750A5043138474 @default.
- W4313365750 hasAuthorship W4313365750A5055388797 @default.
- W4313365750 hasAuthorship W4313365750A5072256301 @default.
- W4313365750 hasConcept C104317684 @default.
- W4313365750 hasConcept C140704245 @default.
- W4313365750 hasConcept C143065580 @default.
- W4313365750 hasConcept C159047783 @default.
- W4313365750 hasConcept C159654299 @default.
- W4313365750 hasConcept C202878990 @default.
- W4313365750 hasConcept C2522874641 @default.
- W4313365750 hasConcept C2780644213 @default.
- W4313365750 hasConcept C35693153 @default.
- W4313365750 hasConcept C501734568 @default.
- W4313365750 hasConcept C542903549 @default.
- W4313365750 hasConcept C54355233 @default.
- W4313365750 hasConcept C58475186 @default.
- W4313365750 hasConcept C86803240 @default.
- W4313365750 hasConceptScore W4313365750C104317684 @default.
- W4313365750 hasConceptScore W4313365750C140704245 @default.
- W4313365750 hasConceptScore W4313365750C143065580 @default.
- W4313365750 hasConceptScore W4313365750C159047783 @default.
- W4313365750 hasConceptScore W4313365750C159654299 @default.
- W4313365750 hasConceptScore W4313365750C202878990 @default.
- W4313365750 hasConceptScore W4313365750C2522874641 @default.
- W4313365750 hasConceptScore W4313365750C2780644213 @default.
- W4313365750 hasConceptScore W4313365750C35693153 @default.
- W4313365750 hasConceptScore W4313365750C501734568 @default.
- W4313365750 hasConceptScore W4313365750C542903549 @default.
- W4313365750 hasConceptScore W4313365750C54355233 @default.
- W4313365750 hasConceptScore W4313365750C58475186 @default.
- W4313365750 hasConceptScore W4313365750C86803240 @default.
- W4313365750 hasIssue "1_Supplement" @default.
- W4313365750 hasLocation W43133657501 @default.
- W4313365750 hasOpenAccess W4313365750 @default.
- W4313365750 hasPrimaryLocation W43133657501 @default.
- W4313365750 hasRelatedWork W1572227522 @default.
- W4313365750 hasRelatedWork W2006514888 @default.
- W4313365750 hasRelatedWork W2015453934 @default.
- W4313365750 hasRelatedWork W2079340339 @default.
- W4313365750 hasRelatedWork W2100232224 @default.
- W4313365750 hasRelatedWork W2103796054 @default.
- W4313365750 hasRelatedWork W2110097466 @default.
- W4313365750 hasRelatedWork W2170804051 @default.
- W4313365750 hasRelatedWork W2464528200 @default.
- W4313365750 hasRelatedWork W604613273 @default.
- W4313365750 hasVolume "202" @default.
- W4313365750 isParatext "false" @default.
- W4313365750 isRetracted "false" @default.
- W4313365750 workType "article" @default.