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- W4313365770 abstract "Abstract Early signaling events through the antigen receptor in CD4+ T cells occur in and around the lipid microenvironment of the plasma membrane. The plasma membrane of all eukaryotic cells have phospholipids, cholesterol and transmembrane/lipid anchored proteins organized in small and dynamic ordered (Io) and disordered (Id) –like phases. Lipid rafts are nanometer-sized, cholesterol and saturated phospholipid-rich domains that contribute to the Io phase. Interaction between CD4+ T cells with antigen presenting cells during antigen presentation stabilize and/or promote coalescing of Io nanometer size domains that are normally scattered on the plasma membrane. To assess the role of membrane order in CD4+ T cell responses we used recombinant klotho protein that is known to bind glycolipids in membrane lipid rafts and destabilize these nanometer-sized domains. Klotho is a naturally occurring protein in mice and humans - the soluble form of this protein circulates in the body, and acts as a hormone to promote longevity in mice as well as enhance cognitive function in humans. However, its possible immunologic effects are unknown. We have examined the effects of recombinant klotho protein on CD4+ T cell responses in-vitro. We found that klotho hormone inhibits clonal expansion of CD4+ T cell in an antigen-specific manner, promotes apoptosis in CD4+ T cells from younger mice (< 8 weeks) although these inhibitory effects are minimal or not observed in CD4+ T cells from older mice (>8 weeks). -In-vivo experiments to further investigate the role of soluble klotho protein are underway, and will be reported." @default.
- W4313365770 created "2023-01-06" @default.
- W4313365770 creator A5036098367 @default.
- W4313365770 creator A5052791946 @default.
- W4313365770 date "2019-05-01" @default.
- W4313365770 modified "2023-09-26" @default.
- W4313365770 title "Inhibitory effects of Klotho hormone on antigen-specific clonal expansion of CD4+ T cells" @default.
- W4313365770 doi "https://doi.org/10.4049/jimmunol.202.supp.186.7" @default.
- W4313365770 hasPublicationYear "2019" @default.
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