FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313365799> ?p ?o ?g. }

• W4313365799 abstract "Abstract Dysregulated trophoblast proliferation, invasion, and apoptosis may cause several pregnancy‐associated complications, such as unexplained recurrent spontaneous abortion (URSA). Recent studies have shown that metabolic abnormalities, including glycolysis inhibition, may dysregulate trophoblast function, leading to URSA. However, the underlying mechanisms remain unclear. Herein, we found that lactate dehydrogenase A (LDHA), a key enzyme in glycolysis, was significantly reduced in the placental villus of URSA patients. The human trophoblast cell line HTR‐8/SVneo was used to investigate the possible LDHA‐mediated regulation of trophoblast function. LDHA knockdown in HTR‐8/SVneo cells induced G0/G1 phase arrest and increased apoptosis, whereas LDHA overexpression reversed these effects. Next, RNA sequencing combined with Kyoto Encyclopedia of Genes and Genomes analysis demonstrated that the PI3K/AKT signaling pathway is potentially affected by downstream genes of LDHA. Especially, we found that LDHA knockdown decreased the phosphorylation levels of PI3K, AKT, and FOXO1, resulting in a significant downregulation of CyclinD1. In addition, treatment with an AKT inhibitor or FOXO1 inhibitor also verified that the PI3K/AKT/FOXO1 signaling pathway influenced the gene expression of CyclinD1 in trophoblast. Moreover, p‐AKT expression correlated positively with LDHA expression in syncytiotrophoblasts and extravillous trophoblasts in first‐trimester villus. Collectively, this study revealed a new regulatory pathway for LDHA/PI3K/AKT/FOXO1/CyclinD1 in the trophoblast cell cycle and proliferation." @default.
• W4313365799 created "2023-01-06" @default.
• W4313365799 creator A5003637167 @default.
• W4313365799 creator A5015226781 @default.
• W4313365799 creator A5038805449 @default.
• W4313365799 creator A5054321147 @default.
• W4313365799 creator A5058928128 @default.
• W4313365799 creator A5069279911 @default.
• W4313365799 creator A5077632077 @default.
• W4313365799 creator A5090942414 @default.
• W4313365799 date "2022-12-30" @default.
• W4313365799 modified "2023-10-14" @default.
• W4313365799 title "<scp>LDHA</scp> deficiency inhibits trophoblast proliferation via the <scp>PI3K</scp>/<scp>AKT</scp>/<scp>FOXO1</scp>/<scp>CyclinD1</scp> signaling pathway in unexplained recurrent spontaneous abortion" @default.
• W4313365799 cites W1643431644 @default.
• W4313365799 cites W1982245720 @default.
• W4313365799 cites W1983919608 @default.
• W4313365799 cites W1999913538 @default.
• W4313365799 cites W2015449504 @default.
• W4313365799 cites W2024562235 @default.
• W4313365799 cites W2044252588 @default.
• W4313365799 cites W2055546884 @default.
• W4313365799 cites W2074546742 @default.
• W4313365799 cites W2095987251 @default.
• W4313365799 cites W2100963977 @default.
• W4313365799 cites W2108812570 @default.
• W4313365799 cites W2113400357 @default.
• W4313365799 cites W2132053398 @default.
• W4313365799 cites W2133190342 @default.
• W4313365799 cites W2146569590 @default.
• W4313365799 cites W2517338797 @default.
• W4313365799 cites W2519020116 @default.
• W4313365799 cites W2577166044 @default.
• W4313365799 cites W2589026565 @default.
• W4313365799 cites W2595462393 @default.
• W4313365799 cites W2693237708 @default.
• W4313365799 cites W2735189515 @default.
• W4313365799 cites W2766972589 @default.
• W4313365799 cites W2767989010 @default.
• W4313365799 cites W2768795275 @default.
• W4313365799 cites W2806098184 @default.
• W4313365799 cites W2809642886 @default.
• W4313365799 cites W2834341622 @default.
• W4313365799 cites W2885122198 @default.
• W4313365799 cites W2900719964 @default.
• W4313365799 cites W2903553774 @default.
• W4313365799 cites W2912263218 @default.
• W4313365799 cites W2917964400 @default.
• W4313365799 cites W2946234587 @default.
• W4313365799 cites W2953213351 @default.
• W4313365799 cites W2963877662 @default.
• W4313365799 cites W2977044530 @default.
• W4313365799 cites W2990237704 @default.
• W4313365799 cites W2994540922 @default.
• W4313365799 cites W2994749187 @default.
• W4313365799 cites W3008221221 @default.
• W4313365799 cites W3011934461 @default.
• W4313365799 cites W3012408828 @default.
• W4313365799 cites W3081053068 @default.
• W4313365799 cites W3124771528 @default.
• W4313365799 cites W3144861820 @default.
• W4313365799 cites W3162194020 @default.
• W4313365799 cites W3171653527 @default.
• W4313365799 cites W3193598804 @default.
• W4313365799 cites W3197997300 @default.
• W4313365799 cites W3198201872 @default.
• W4313365799 cites W3209138845 @default.
• W4313365799 cites W4200133820 @default.
• W4313365799 cites W4226139357 @default.
• W4313365799 cites W4226149303 @default.
• W4313365799 cites W4253046392 @default.
• W4313365799 cites W628038580 @default.
• W4313365799 doi "https://doi.org/10.1096/fj.202201219rr" @default.
• W4313365799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36583693" @default.
• W4313365799 hasPublicationYear "2022" @default.
• W4313365799 type Work @default.
• W4313365799 citedByCount "1" @default.
• W4313365799 countsByYear W43133657992023 @default.
• W4313365799 crossrefType "journal-article" @default.
• W4313365799 hasAuthorship W4313365799A5003637167 @default.
• W4313365799 hasAuthorship W4313365799A5015226781 @default.
• W4313365799 hasAuthorship W4313365799A5038805449 @default.
• W4313365799 hasAuthorship W4313365799A5054321147 @default.
• W4313365799 hasAuthorship W4313365799A5058928128 @default.
• W4313365799 hasAuthorship W4313365799A5069279911 @default.
• W4313365799 hasAuthorship W4313365799A5077632077 @default.
• W4313365799 hasAuthorship W4313365799A5090942414 @default.
• W4313365799 hasConcept C134018914 @default.
• W4313365799 hasConcept C140149449 @default.
• W4313365799 hasConcept C172680121 @default.
• W4313365799 hasConcept C173396325 @default.
• W4313365799 hasConcept C190283241 @default.
• W4313365799 hasConcept C20251656 @default.
• W4313365799 hasConcept C2776953305 @default.
• W4313365799 hasConcept C2777495146 @default.
• W4313365799 hasConcept C2779234561 @default.
• W4313365799 hasConcept C2908795334 @default.
• W4313365799 hasConcept C2910680157 @default.
• W4313365799 hasConcept C502942594 @default.
• W4313365799 hasConcept C54355233 @default.
• W4313365799 hasConcept C55493867 @default.

• next