FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313365837> ?p ?o ?g. }

• W4313365837 abstract "Abstract The molecular hallmark of Burkitt lymphoma (BL) is a chromosomal translocation that results in deregulated expression of MYC oncogene. This translocation is present in virtually all BL. MYC is an oncogenic transcription factor deregulated in about half of total human tumors, by translocation or other mechanisms. Transcriptomic studies reveal more than 1000 genes regulated by MYC but a much smaller fraction of these genes is directly activated by MYC. All the endemic BL and many sporadic BL cells are associated to the Epstein-Barr virus (EBV) infection. The currently accepted mechanism for the MYC and BL association is that EBV is the causing agent inducing MYC translocation. Complement receptor 2 or CR2 (also called CD21) is a membrane protein that serves as EBV receptor in lymphoid cells. Here we show that CR2 is a direct MYC target gene. This conclusion is based on several evidences. First, MYC downregulation is linked to CR2 downregulation both in proliferating and in arrested cells. Second, MYC binds human CR2 promoter and this binding depends on E-box elements. Third, MYC activates CR2 promoter in an E-box dependent manner. Four, MYC activates CR2 transcription in the absence of protein synthesis. Importantly, MYC also induces CR2 expression in mouse primary B cells. Thus, CR2 is a bona fide MYC direct target gene. Moreover, higher MYC expression levels in Burkitt lymphoma-derived cells result in a more efficient EBV infection. We propose an alternative mechanism compatible with the correlation between EBV infection and MYC translocation observed in endemic BL, i.e., that deregulated MYC in BL cells occurs first and favors the EBV infection." @default.
• W4313365837 created "2023-01-06" @default.
• W4313365837 creator A5004127149 @default.
• W4313365837 creator A5004612150 @default.
• W4313365837 creator A5010713127 @default.
• W4313365837 creator A5013860928 @default.
• W4313365837 creator A5018858940 @default.
• W4313365837 creator A5025114136 @default.
• W4313365837 creator A5026040664 @default.
• W4313365837 creator A5036887524 @default.
• W4313365837 creator A5053789063 @default.
• W4313365837 creator A5055921939 @default.
• W4313365837 creator A5057769070 @default.
• W4313365837 creator A5058146884 @default.
• W4313365837 creator A5063420543 @default.
• W4313365837 creator A5070614261 @default.
• W4313365837 creator A5078291637 @default.
• W4313365837 creator A5088061809 @default.
• W4313365837 date "2022-12-29" @default.
• W4313365837 modified "2023-10-14" @default.
• W4313365837 title "MYC directly transactivates CR2/CD21, the receptor of the Epstein-Barr virus, and enhances the viral infection of Burkitt lymphoma cells" @default.
• W4313365837 cites W1484714452 @default.
• W4313365837 cites W1519290346 @default.
• W4313365837 cites W1579336178 @default.
• W4313365837 cites W1795201567 @default.
• W4313365837 cites W1878169898 @default.
• W4313365837 cites W1966951079 @default.
• W4313365837 cites W1968075576 @default.
• W4313365837 cites W1971439989 @default.
• W4313365837 cites W1972078736 @default.
• W4313365837 cites W1974983696 @default.
• W4313365837 cites W1981807499 @default.
• W4313365837 cites W1984822831 @default.
• W4313365837 cites W1986006520 @default.
• W4313365837 cites W1988821953 @default.
• W4313365837 cites W1992198197 @default.
• W4313365837 cites W2007490905 @default.
• W4313365837 cites W2007648282 @default.
• W4313365837 cites W2007981920 @default.
• W4313365837 cites W2009949436 @default.
• W4313365837 cites W2011924190 @default.
• W4313365837 cites W2016878346 @default.
• W4313365837 cites W2021536610 @default.
• W4313365837 cites W2027671549 @default.
• W4313365837 cites W2032972450 @default.
• W4313365837 cites W2035611379 @default.
• W4313365837 cites W2041524501 @default.
• W4313365837 cites W2046541807 @default.
• W4313365837 cites W2050672588 @default.
• W4313365837 cites W2051301388 @default.
• W4313365837 cites W2058218780 @default.
• W4313365837 cites W2060236569 @default.
• W4313365837 cites W2068970201 @default.
• W4313365837 cites W2081141657 @default.
• W4313365837 cites W2093913386 @default.
• W4313365837 cites W2114530090 @default.
• W4313365837 cites W2118028844 @default.
• W4313365837 cites W2120006551 @default.
• W4313365837 cites W2134122507 @default.
• W4313365837 cites W2139963681 @default.
• W4313365837 cites W2144294716 @default.
• W4313365837 cites W2144965236 @default.
• W4313365837 cites W2149441684 @default.
• W4313365837 cites W2150786495 @default.
• W4313365837 cites W2158107632 @default.
• W4313365837 cites W2160014402 @default.
• W4313365837 cites W2161577298 @default.
• W4313365837 cites W2167869412 @default.
• W4313365837 cites W2406676791 @default.
• W4313365837 cites W2526219494 @default.
• W4313365837 cites W2561038494 @default.
• W4313365837 cites W2618573553 @default.
• W4313365837 cites W2736443756 @default.
• W4313365837 cites W2768766207 @default.
• W4313365837 cites W2790846487 @default.
• W4313365837 cites W2795073885 @default.
• W4313365837 cites W2888625676 @default.
• W4313365837 cites W2910996719 @default.
• W4313365837 cites W2922501427 @default.
• W4313365837 cites W2922610698 @default.
• W4313365837 cites W2954390295 @default.
• W4313365837 cites W2985546733 @default.
• W4313365837 cites W3016787401 @default.
• W4313365837 cites W302073403 @default.
• W4313365837 cites W3095371282 @default.
• W4313365837 cites W3173153622 @default.
• W4313365837 cites W4236967220 @default.
• W4313365837 cites W4289886667 @default.
• W4313365837 cites W65539241 @default.
• W4313365837 doi "https://doi.org/10.1101/2022.12.28.522143" @default.
• W4313365837 hasPublicationYear "2022" @default.
• W4313365837 type Work @default.
• W4313365837 citedByCount "0" @default.
• W4313365837 crossrefType "posted-content" @default.
• W4313365837 hasAuthorship W4313365837A5004127149 @default.
• W4313365837 hasAuthorship W4313365837A5004612150 @default.
• W4313365837 hasAuthorship W4313365837A5010713127 @default.
• W4313365837 hasAuthorship W4313365837A5013860928 @default.
• W4313365837 hasAuthorship W4313365837A5018858940 @default.
• W4313365837 hasAuthorship W4313365837A5025114136 @default.

• next