Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313365846> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4313365846 endingPage "190.49" @default.
- W4313365846 startingPage "190.49" @default.
- W4313365846 abstract "Abstract In the respiratory tract, Staphylococcus aureus is associated with infections ranging from asymptomatic colonization to severe necrotizing pneumonia. While staphylococcal pneumonia has always been highly associated with influenza infections in young children and the elderly, it has emerged as the major cause of pneumonia associated with influenza since the 2009 H1N1 pandemic. Despite the clinical relevance of methicillin-resistant S. aureus (MRSA), few studies have examined bacterial factors of MRSA in pneumonia and how preceding influenza may alter the behavior of MRSA in the lung. Successful establishment of infection by bacterial pathogens requires adhesion to host cells. Staphylococcal species express a broad range of surface proteins that are involved in adhesion to host cells, known as the MSCRAMM family. MSCRAMM proteins have known roles in upper respiratory tract colonization, however their role in the lung is unknown. Preliminary data suggest that the MSCRAMM family members are important within the lung as MRSA lacking all MSCRAMMs (ΔsrtA) has decreased immune infiltrate in influenza super-infection. Additionally, the MSCRAMM family member SdrD has a role in both bacterial adherence as well as epithelial integrity and immunity in MRSA pneumonia and super-infection. Mice infected with MRSA lacking SdrD (ΔsdrD) have lower bacterial burden and increased expression of epithelial antimicrobial peptides cathelicidin and Reg3g with no difference in overall inflammation measured by immune infiltrate and pro-inflammatory cytokine levels. This suggests that MSCRAMM family members play a role in infection within the lung in both MRSA pneumonia and super-infection and can alter the immune response." @default.
- W4313365846 created "2023-01-06" @default.
- W4313365846 creator A5053871178 @default.
- W4313365846 creator A5076278523 @default.
- W4313365846 creator A5085072225 @default.
- W4313365846 creator A5086405994 @default.
- W4313365846 date "2019-05-01" @default.
- W4313365846 modified "2023-10-04" @default.
- W4313365846 title "Adhesion requirements of methicillin-resistant <i>Staphylococcus aureus</i> in bacterial pneumonia and influenza super-infection" @default.
- W4313365846 doi "https://doi.org/10.4049/jimmunol.202.supp.190.49" @default.
- W4313365846 hasPublicationYear "2019" @default.
- W4313365846 type Work @default.
- W4313365846 citedByCount "1" @default.
- W4313365846 countsByYear W43133658462019 @default.
- W4313365846 crossrefType "journal-article" @default.
- W4313365846 hasAuthorship W4313365846A5053871178 @default.
- W4313365846 hasAuthorship W4313365846A5076278523 @default.
- W4313365846 hasAuthorship W4313365846A5085072225 @default.
- W4313365846 hasAuthorship W4313365846A5086405994 @default.
- W4313365846 hasConcept C126322002 @default.
- W4313365846 hasConcept C203014093 @default.
- W4313365846 hasConcept C2776345407 @default.
- W4313365846 hasConcept C2777052132 @default.
- W4313365846 hasConcept C2777334864 @default.
- W4313365846 hasConcept C2777714996 @default.
- W4313365846 hasConcept C2777914695 @default.
- W4313365846 hasConcept C2779489039 @default.
- W4313365846 hasConcept C2779644171 @default.
- W4313365846 hasConcept C501593827 @default.
- W4313365846 hasConcept C523546767 @default.
- W4313365846 hasConcept C534529494 @default.
- W4313365846 hasConcept C54355233 @default.
- W4313365846 hasConcept C71924100 @default.
- W4313365846 hasConcept C86803240 @default.
- W4313365846 hasConcept C8891405 @default.
- W4313365846 hasConcept C89423630 @default.
- W4313365846 hasConceptScore W4313365846C126322002 @default.
- W4313365846 hasConceptScore W4313365846C203014093 @default.
- W4313365846 hasConceptScore W4313365846C2776345407 @default.
- W4313365846 hasConceptScore W4313365846C2777052132 @default.
- W4313365846 hasConceptScore W4313365846C2777334864 @default.
- W4313365846 hasConceptScore W4313365846C2777714996 @default.
- W4313365846 hasConceptScore W4313365846C2777914695 @default.
- W4313365846 hasConceptScore W4313365846C2779489039 @default.
- W4313365846 hasConceptScore W4313365846C2779644171 @default.
- W4313365846 hasConceptScore W4313365846C501593827 @default.
- W4313365846 hasConceptScore W4313365846C523546767 @default.
- W4313365846 hasConceptScore W4313365846C534529494 @default.
- W4313365846 hasConceptScore W4313365846C54355233 @default.
- W4313365846 hasConceptScore W4313365846C71924100 @default.
- W4313365846 hasConceptScore W4313365846C86803240 @default.
- W4313365846 hasConceptScore W4313365846C8891405 @default.
- W4313365846 hasConceptScore W4313365846C89423630 @default.
- W4313365846 hasIssue "1_Supplement" @default.
- W4313365846 hasLocation W43133658461 @default.
- W4313365846 hasOpenAccess W4313365846 @default.
- W4313365846 hasPrimaryLocation W43133658461 @default.
- W4313365846 hasRelatedWork W2094758336 @default.
- W4313365846 hasRelatedWork W2102251677 @default.
- W4313365846 hasRelatedWork W2109861005 @default.
- W4313365846 hasRelatedWork W2119606443 @default.
- W4313365846 hasRelatedWork W2126779278 @default.
- W4313365846 hasRelatedWork W2137540804 @default.
- W4313365846 hasRelatedWork W2201825540 @default.
- W4313365846 hasRelatedWork W2592620649 @default.
- W4313365846 hasRelatedWork W2918578413 @default.
- W4313365846 hasRelatedWork W2983152282 @default.
- W4313365846 hasVolume "202" @default.
- W4313365846 isParatext "false" @default.
- W4313365846 isRetracted "false" @default.
- W4313365846 workType "article" @default.