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- W4313365870 abstract "Abstract Introduction While change of intracellular metabolism in T cell activation is well studied, whether T cell activation affects systemic metabolome outside cells is largely unknown. In present study, we examined systemic metabolome change in T cell activation and its effect on brain functions like emotional behaviors. Results Concentrations of amino acids in sera were decreased in PD-1-deficient mice in a T cell-dependent manner. On the other hands, concentrations of amino acids in lymph node were increased in lymph node of PD-1 deficient mice with increased number of total and activated T cells. Activated T cells increased expression of amino acid transporter and intracellular incorporations of tryptophan and tyrosine, two representative amino acids. Decreased concentrations of serum tryptophan and tyrosine lead to decreased serotonin and dopamine in brain of PD-1-deficient mice. PD-1-deficient mice showed enhanced anxiety-like behaviors and fear response. Conclusions Enhanced incorporation of amino acids in activated T cells leads to serum decrease in amino acids, which leads to serotonin and dopamine decrease in brain and enhanced anxiety-like behavior and fear response in PD-1-deficient mice." @default.
- W4313365870 created "2023-01-06" @default.
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- W4313365870 date "2019-05-01" @default.
- W4313365870 modified "2023-09-26" @default.
- W4313365870 title "Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior" @default.
- W4313365870 doi "https://doi.org/10.4049/jimmunol.202.supp.56.2" @default.
- W4313365870 hasPublicationYear "2019" @default.
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