Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313365912> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4313365912 endingPage "60.14" @default.
- W4313365912 startingPage "60.14" @default.
- W4313365912 abstract "Abstract The memory CD8+ T cell population consists of distinct subsets that collaborate to provide robust immunological protection. Within the circulation, two broad classes exist – the shorter-lived effector and effector memory (TEM) cells with heightened effector function for immediate protection and the longer-lived central memory (TCM) cells with stem-like qualities and increased proliferation potential. Tissue-resident memory (TRM) cells are the prominent cell type permanently residing in non-lymphoid tissues acting as sentinels against reinfection. Despite the critical importance of the TRM subset, the extent of their phenotypic and functional heterogeneity remains unknown. Using single-cell gene expression analyses, we assessed small intestine intraepithelial TRM cells over the course of acute infection. Distinct subsets were identified and distinguished by reciprocal expression of effector- and memory-associated transcriptional regulators, Blimp1 and Id3, respectively. While the Blimp1hi subset was prominent at early time points, the Id3hi population persisted and was more abundant over time. Importantly, examination of the subset-specific transcriptional profiles revealed considerable enrichment for the effector/effector-memory gene signature within the Blimp1hiTRM subset and the central-memory gene signature within the Id3hi TRM population. Furthermore, Id3hi TRM cells exhibited more stem-like characteristics including increased capacity to proliferate following rechallenge. Taken together, this study reveals that similar to circulating memory, the TRM population is heterogeneous, comprising cells with contrasting differentiation states and memory potential." @default.
- W4313365912 created "2023-01-06" @default.
- W4313365912 creator A5012998783 @default.
- W4313365912 creator A5055310419 @default.
- W4313365912 creator A5056609060 @default.
- W4313365912 creator A5061033695 @default.
- W4313365912 creator A5064546316 @default.
- W4313365912 creator A5088835874 @default.
- W4313365912 date "2019-05-01" @default.
- W4313365912 modified "2023-09-26" @default.
- W4313365912 title "Identification of TRM subsets with distinct cellular states and memory potential" @default.
- W4313365912 doi "https://doi.org/10.4049/jimmunol.202.supp.60.14" @default.
- W4313365912 hasPublicationYear "2019" @default.
- W4313365912 type Work @default.
- W4313365912 citedByCount "0" @default.
- W4313365912 crossrefType "journal-article" @default.
- W4313365912 hasAuthorship W4313365912A5012998783 @default.
- W4313365912 hasAuthorship W4313365912A5055310419 @default.
- W4313365912 hasAuthorship W4313365912A5056609060 @default.
- W4313365912 hasAuthorship W4313365912A5061033695 @default.
- W4313365912 hasAuthorship W4313365912A5064546316 @default.
- W4313365912 hasAuthorship W4313365912A5088835874 @default.
- W4313365912 hasConcept C104317684 @default.
- W4313365912 hasConcept C121332964 @default.
- W4313365912 hasConcept C127716648 @default.
- W4313365912 hasConcept C147483822 @default.
- W4313365912 hasConcept C165801399 @default.
- W4313365912 hasConcept C167672396 @default.
- W4313365912 hasConcept C172385210 @default.
- W4313365912 hasConcept C203014093 @default.
- W4313365912 hasConcept C2776638159 @default.
- W4313365912 hasConcept C2777367678 @default.
- W4313365912 hasConcept C28328180 @default.
- W4313365912 hasConcept C2908647359 @default.
- W4313365912 hasConcept C51785407 @default.
- W4313365912 hasConcept C54355233 @default.
- W4313365912 hasConcept C62520636 @default.
- W4313365912 hasConcept C71924100 @default.
- W4313365912 hasConcept C86803240 @default.
- W4313365912 hasConcept C95444343 @default.
- W4313365912 hasConcept C99454951 @default.
- W4313365912 hasConceptScore W4313365912C104317684 @default.
- W4313365912 hasConceptScore W4313365912C121332964 @default.
- W4313365912 hasConceptScore W4313365912C127716648 @default.
- W4313365912 hasConceptScore W4313365912C147483822 @default.
- W4313365912 hasConceptScore W4313365912C165801399 @default.
- W4313365912 hasConceptScore W4313365912C167672396 @default.
- W4313365912 hasConceptScore W4313365912C172385210 @default.
- W4313365912 hasConceptScore W4313365912C203014093 @default.
- W4313365912 hasConceptScore W4313365912C2776638159 @default.
- W4313365912 hasConceptScore W4313365912C2777367678 @default.
- W4313365912 hasConceptScore W4313365912C28328180 @default.
- W4313365912 hasConceptScore W4313365912C2908647359 @default.
- W4313365912 hasConceptScore W4313365912C51785407 @default.
- W4313365912 hasConceptScore W4313365912C54355233 @default.
- W4313365912 hasConceptScore W4313365912C62520636 @default.
- W4313365912 hasConceptScore W4313365912C71924100 @default.
- W4313365912 hasConceptScore W4313365912C86803240 @default.
- W4313365912 hasConceptScore W4313365912C95444343 @default.
- W4313365912 hasConceptScore W4313365912C99454951 @default.
- W4313365912 hasIssue "1_Supplement" @default.
- W4313365912 hasLocation W43133659121 @default.
- W4313365912 hasOpenAccess W4313365912 @default.
- W4313365912 hasPrimaryLocation W43133659121 @default.
- W4313365912 hasRelatedWork W2039134318 @default.
- W4313365912 hasRelatedWork W2113119609 @default.
- W4313365912 hasRelatedWork W2255795958 @default.
- W4313365912 hasRelatedWork W2336657798 @default.
- W4313365912 hasRelatedWork W2409748289 @default.
- W4313365912 hasRelatedWork W4210263702 @default.
- W4313365912 hasRelatedWork W422075661 @default.
- W4313365912 hasRelatedWork W4290216884 @default.
- W4313365912 hasRelatedWork W4313349963 @default.
- W4313365912 hasRelatedWork W4362421678 @default.
- W4313365912 hasVolume "202" @default.
- W4313365912 isParatext "false" @default.
- W4313365912 isRetracted "false" @default.
- W4313365912 workType "article" @default.