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- W4313365932 abstract "Abstract Currently over 600 million people worldwide are over the age of 65. This number is predicted to reach 1.6 billion by 2050, representing a 17 percent increase in the world’s aged population. This amazing achievement also presents with concerns, notably our inability to effectively treat older patients with diseases of varying etiologies. Chronic inflammation, which commonly manifests in aged populations, has been shown to promote oncogenesis and compromise immunity. However, the relationship between these aging-associated manifestations are still unclear. In preliminary studies we found that aging-associated inflammation promotes the expansion of inhibitory immune cells in the spleen, increases the surface expression of the inhibitory mediators PD1/PD-L1 on immune cells, and attenuates interferon-gamma (IFN-γ) production in both CD4+ and CD8+ T-cells. Surprisingly, we have discovered that the anti-inflammatory cytokine interleukin-37 (IL-37) significantly reduces inflammation in aged mice and restores IFN-γ production in both T-lymphocyte populations to almost youthful levels. Importantly, recombinant IL-37 (rIL-37) significantly extends the survival of aged mice with Ph+ leukemia. These observations suggest that chronic inflammation attenuates immunity in aged mice which can be rejuvenated by IL-37 exposure. Since attenuated immunity and increased disease prevalence are hallmarks of aging, our studies highlight the potential use of rIL-37 as a treatment strategy to improve immunity in aged populations to combat disease." @default.
- W4313365932 created "2023-01-06" @default.
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- W4313365932 date "2019-05-01" @default.
- W4313365932 modified "2023-09-26" @default.
- W4313365932 title "Interleukin-37 improves aging-associated declines in adaptive immunity leading to enhanced suppression of Ph+ leukemia" @default.
- W4313365932 doi "https://doi.org/10.4049/jimmunol.202.supp.65.8" @default.
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