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- W4313365965 abstract "Abstract Heart transplants are the only treatment for end-stage heart failure. Over 3000 heart transplants were performed in the United States in 2016, making heart transplant the most common cadaveric organ transplant. Long-term survival of heart transplants remains a significant clinical concern, and median survival rates after the first year have not significantly improved in 25 years. We have previously shown that pro-inflammatory co-morbidities such as hyperlipidemia contribute to accelerated IL-17 dependent rejection of the transplanted heart. Hyperlipidemia, an increased level of triglycerides and lipids in the blood, is extremely prevalent in the transplant patient population, with nearly 90% of heart transplant recipients becoming hyperlipidemic after their transplant, despite universal use of statins in the transplant patient population. The work described in this poster aims to further explore the mechanisms by which hyperlipidemia promotes Th17-mediated graft rejection, especially the potential interplay between the hyperlipidemic state and CD4 T cell plasticity. By using a MHC-II mismatched heart graft model, immunocytochemistry staining, a Th17 lineage trace, and genetic and chemical ablation of inflammatory cytokines and lineages, we aim to elucidate the differences in inflammatory T-cell infiltrate between graft-destructive accelerated hyperlipidemic rejection and chronic non-hyperlipidemic transplant rejection. This work may lead to more precise targeting of immunosuppression in heart transplant patients and improved survival and quality of life in this patient population" @default.
- W4313365965 created "2023-01-06" @default.
- W4313365965 creator A5005360212 @default.
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- W4313365965 date "2019-05-01" @default.
- W4313365965 modified "2023-09-26" @default.
- W4313365965 title "The Th17 lineage in heart transplant rejection: Examining plasticity and pathogenicity" @default.
- W4313365965 doi "https://doi.org/10.4049/jimmunol.202.supp.69.31" @default.
- W4313365965 hasPublicationYear "2019" @default.
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