Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313365971> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4313365971 endingPage "182.69" @default.
- W4313365971 startingPage "182.69" @default.
- W4313365971 abstract "Abstract Background Exposure of patient blood to the bypass circuitry and re-perfusion of the heart at the end of coronary artery bypass grafting (CABG) is associated with activation of leucocytes, the complement cascade and cytokine secretion. Dendritic cells (DC) and monocytes are immunoregulatory cells that may be impacted by CABG contributing to an altered immune status. This study investigated changes in the DC and monocyte immune profile in CABG patients at 5 time-points: admission, peri-operative, ICU, day 3 (D3) and day 5 (D5). Methods At each time point, freshly collected whole blood from 50 CABG patients was used in an ex-vivo whole blood culture model. Lipopolysaccharide (LPS) was added in parallel to model an infectious complication. Expression of DC and monocyte co-stimulatory and adhesion molecules and production of intracellular inflammatory mediators was measured via flow cytometry. Results CABG resulted in significant perturbation of monocyte and DC responses. DC and monocytes were immunoparalysed as evidenced by failure to respond to LPS stimulation. Modulation of DC and monocyte costimulatory and adhesion molecule expression and inflammatory mediator production was associated with prolonged length of stay in intensive care and post-operative atrial fibrillation. While DC and monocyte expression of co-stimulatory and adhesion molecules recovered towards baseline by D5 post-surgery, their capacity to produce inflammatory mediators did not. Conclusions DC and monocyte responses were significantly impaired following CABG. Use of an ex-vivo model to assess immune competency of cardiac surgery patients may provide a tool for the early prediction of adverse outcomes." @default.
- W4313365971 created "2023-01-06" @default.
- W4313365971 creator A5003199987 @default.
- W4313365971 creator A5009899535 @default.
- W4313365971 creator A5018915616 @default.
- W4313365971 creator A5022895698 @default.
- W4313365971 creator A5030697785 @default.
- W4313365971 creator A5031662701 @default.
- W4313365971 creator A5043407144 @default.
- W4313365971 creator A5048009025 @default.
- W4313365971 creator A5050826666 @default.
- W4313365971 creator A5053211064 @default.
- W4313365971 creator A5055260649 @default.
- W4313365971 creator A5059498904 @default.
- W4313365971 creator A5059606227 @default.
- W4313365971 creator A5068465959 @default.
- W4313365971 creator A5076190767 @default.
- W4313365971 creator A5088709642 @default.
- W4313365971 date "2019-05-01" @default.
- W4313365971 modified "2023-09-27" @default.
- W4313365971 title "Coronary artery bypass grafting surgery is associated with immunoparalysis of monocytes and dendritic cells" @default.
- W4313365971 doi "https://doi.org/10.4049/jimmunol.202.supp.182.69" @default.
- W4313365971 hasPublicationYear "2019" @default.
- W4313365971 type Work @default.
- W4313365971 citedByCount "0" @default.
- W4313365971 crossrefType "journal-article" @default.
- W4313365971 hasAuthorship W4313365971A5003199987 @default.
- W4313365971 hasAuthorship W4313365971A5009899535 @default.
- W4313365971 hasAuthorship W4313365971A5018915616 @default.
- W4313365971 hasAuthorship W4313365971A5022895698 @default.
- W4313365971 hasAuthorship W4313365971A5030697785 @default.
- W4313365971 hasAuthorship W4313365971A5031662701 @default.
- W4313365971 hasAuthorship W4313365971A5043407144 @default.
- W4313365971 hasAuthorship W4313365971A5048009025 @default.
- W4313365971 hasAuthorship W4313365971A5050826666 @default.
- W4313365971 hasAuthorship W4313365971A5053211064 @default.
- W4313365971 hasAuthorship W4313365971A5055260649 @default.
- W4313365971 hasAuthorship W4313365971A5059498904 @default.
- W4313365971 hasAuthorship W4313365971A5059606227 @default.
- W4313365971 hasAuthorship W4313365971A5068465959 @default.
- W4313365971 hasAuthorship W4313365971A5076190767 @default.
- W4313365971 hasAuthorship W4313365971A5088709642 @default.
- W4313365971 hasConcept C126322002 @default.
- W4313365971 hasConcept C150903083 @default.
- W4313365971 hasConcept C1621761 @default.
- W4313365971 hasConcept C164705383 @default.
- W4313365971 hasConcept C203014093 @default.
- W4313365971 hasConcept C207001950 @default.
- W4313365971 hasConcept C26291073 @default.
- W4313365971 hasConcept C2776820930 @default.
- W4313365971 hasConcept C2778754761 @default.
- W4313365971 hasConcept C2781184567 @default.
- W4313365971 hasConcept C71924100 @default.
- W4313365971 hasConcept C86803240 @default.
- W4313365971 hasConcept C8891405 @default.
- W4313365971 hasConceptScore W4313365971C126322002 @default.
- W4313365971 hasConceptScore W4313365971C150903083 @default.
- W4313365971 hasConceptScore W4313365971C1621761 @default.
- W4313365971 hasConceptScore W4313365971C164705383 @default.
- W4313365971 hasConceptScore W4313365971C203014093 @default.
- W4313365971 hasConceptScore W4313365971C207001950 @default.
- W4313365971 hasConceptScore W4313365971C26291073 @default.
- W4313365971 hasConceptScore W4313365971C2776820930 @default.
- W4313365971 hasConceptScore W4313365971C2778754761 @default.
- W4313365971 hasConceptScore W4313365971C2781184567 @default.
- W4313365971 hasConceptScore W4313365971C71924100 @default.
- W4313365971 hasConceptScore W4313365971C86803240 @default.
- W4313365971 hasConceptScore W4313365971C8891405 @default.
- W4313365971 hasIssue "1_Supplement" @default.
- W4313365971 hasLocation W43133659711 @default.
- W4313365971 hasOpenAccess W4313365971 @default.
- W4313365971 hasPrimaryLocation W43133659711 @default.
- W4313365971 hasRelatedWork W127571219 @default.
- W4313365971 hasRelatedWork W2013765863 @default.
- W4313365971 hasRelatedWork W2037374700 @default.
- W4313365971 hasRelatedWork W2095829296 @default.
- W4313365971 hasRelatedWork W2099688650 @default.
- W4313365971 hasRelatedWork W2171636148 @default.
- W4313365971 hasRelatedWork W2189266546 @default.
- W4313365971 hasRelatedWork W2238222814 @default.
- W4313365971 hasRelatedWork W4285033208 @default.
- W4313365971 hasRelatedWork W4292478925 @default.
- W4313365971 hasVolume "202" @default.
- W4313365971 isParatext "false" @default.
- W4313365971 isRetracted "false" @default.
- W4313365971 workType "article" @default.