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- W4313365988 abstract "Abstract IL-15 is a homeostatic cytokine that induces proliferation of NK cells and memory CD8+ T cells. Recently, clinical trials using various forms of IL-15 in combination with immune checkpoint inhibitors in multiple intractable cancers are on progress. In the present study, we examined effects of IL-15 on tumor-infiltrating CD8+ T cells obtained from human non-small cell lung cancer (NSCLC; n = 20) and synergic effects of IL-15 in combination with anti- PD-1 blocking antibodies. More than 80% of tumor-infiltrating CD8+ T cells expressed PD-1, indicating that they are exhausted. We stimulated tumor-infiltrating CD8+ T cells with anti-CD3 antibodies in the absence or presence of anti-PD-1 blocking antibodies and IL-15 and found that anti-PD-1 treatment increased anti-CD3-stimulated proliferation of tumor-infiltrating CD8+ T cells, indicating that tumor-infiltrating CD8+ T cells were reinvigorated by anti-PD-1. Moreover, IL-15 further enhances anti-PD-1-induced reinvigoration of tumor-infiltrating CD8+ T cells in a dose-dependent manner. These findings indicate that IL-15 might increase therapeutic effects of anti-PD-1 by synergistically enhancing anti-PD-1-induced reinvigoration of tumor-infiltrating CD8+ T cells." @default.
- W4313365988 created "2023-01-06" @default.
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- W4313365988 date "2019-05-01" @default.
- W4313365988 modified "2023-10-16" @default.
- W4313365988 title "IL-15 enhances anti-PD-1-induced reinvigoration of tumor-infiltrating CD8+ T cells" @default.
- W4313365988 doi "https://doi.org/10.4049/jimmunol.202.supp.136.13" @default.
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