Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366070> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313366070 endingPage "66.3" @default.
- W4313366070 startingPage "66.3" @default.
- W4313366070 abstract "Abstract Viral pneumonia leads to significant morbidity and mortality worldwide, demanding better understanding of the host immune response to infections for development of novel strategies to prevent respiratory infections. Our group has shown that mice treated with combination of Toll-like receptor (TLR) 2/6 and 9 agonists (Pam2-ODN) are protected against wide range of respiratory pathogens, including viruses. Mice challenged intra-pharyngeally with Sendai virus showed peak viral burden on day 5 and peak mortality on day 11, overlapping with increased lung CD8+Tcells. We hypothesized that mortality is associated with immunopathology caused by CD8+T cells. Pam2-ODN aerosolization one day prior to Sendai challenge reduced lung viral burden and reduced lung CD8+T cells on day 11 and enhanced mouse survival. Depletion of CD8+T cells before infection increased baseline virus susceptibility and enhanced viral replication in vivo, congruent with the known antiviral function of CD8+T cells. Pam2-ODN pre-treatment protected mice against death following viral challenge, even in the absence of CD8+T cells, reflecting antiviral responses induced directly from epithelial cells. Notably, depletion of CD8+T cells eight days after viral challenge also significantly enhanced survival of sham pre-treated mice, indicating rescue from CD8+T cell-mediated lethal immunopathology. Our findings definitively prove that CD8+T cells, although anti-viral in nature, promote lethal immunopathology that can be prevented by Pam2-ODN pre-treatment. Importantly, Pam2-ODN pre-treatment benefitted survival regardless of when CD8+T cells were depleted and may provide an opportunity to protect vulnerable populations against respiratory infections." @default.
- W4313366070 created "2023-01-06" @default.
- W4313366070 creator A5011187675 @default.
- W4313366070 creator A5046203439 @default.
- W4313366070 creator A5064745949 @default.
- W4313366070 creator A5065158413 @default.
- W4313366070 creator A5071683867 @default.
- W4313366070 creator A5086464414 @default.
- W4313366070 date "2019-05-01" @default.
- W4313366070 modified "2023-09-24" @default.
- W4313366070 title "Inducible epithelial resistance protects against acute viral infection and subsequent CD8+Tcell dependent lethal Immunopathology" @default.
- W4313366070 doi "https://doi.org/10.4049/jimmunol.202.supp.66.3" @default.
- W4313366070 hasPublicationYear "2019" @default.
- W4313366070 type Work @default.
- W4313366070 citedByCount "0" @default.
- W4313366070 crossrefType "journal-article" @default.
- W4313366070 hasAuthorship W4313366070A5011187675 @default.
- W4313366070 hasAuthorship W4313366070A5046203439 @default.
- W4313366070 hasAuthorship W4313366070A5064745949 @default.
- W4313366070 hasAuthorship W4313366070A5065158413 @default.
- W4313366070 hasAuthorship W4313366070A5071683867 @default.
- W4313366070 hasAuthorship W4313366070A5086464414 @default.
- W4313366070 hasConcept C154317977 @default.
- W4313366070 hasConcept C159047783 @default.
- W4313366070 hasConcept C167672396 @default.
- W4313366070 hasConcept C202751555 @default.
- W4313366070 hasConcept C203014093 @default.
- W4313366070 hasConcept C2522874641 @default.
- W4313366070 hasConcept C2780127873 @default.
- W4313366070 hasConcept C2780648854 @default.
- W4313366070 hasConcept C54355233 @default.
- W4313366070 hasConcept C86803240 @default.
- W4313366070 hasConcept C8891405 @default.
- W4313366070 hasConceptScore W4313366070C154317977 @default.
- W4313366070 hasConceptScore W4313366070C159047783 @default.
- W4313366070 hasConceptScore W4313366070C167672396 @default.
- W4313366070 hasConceptScore W4313366070C202751555 @default.
- W4313366070 hasConceptScore W4313366070C203014093 @default.
- W4313366070 hasConceptScore W4313366070C2522874641 @default.
- W4313366070 hasConceptScore W4313366070C2780127873 @default.
- W4313366070 hasConceptScore W4313366070C2780648854 @default.
- W4313366070 hasConceptScore W4313366070C54355233 @default.
- W4313366070 hasConceptScore W4313366070C86803240 @default.
- W4313366070 hasConceptScore W4313366070C8891405 @default.
- W4313366070 hasIssue "1_Supplement" @default.
- W4313366070 hasLocation W43133660701 @default.
- W4313366070 hasOpenAccess W4313366070 @default.
- W4313366070 hasPrimaryLocation W43133660701 @default.
- W4313366070 hasRelatedWork W1025521678 @default.
- W4313366070 hasRelatedWork W1487857142 @default.
- W4313366070 hasRelatedWork W2010825098 @default.
- W4313366070 hasRelatedWork W2026521386 @default.
- W4313366070 hasRelatedWork W2050374169 @default.
- W4313366070 hasRelatedWork W2054408371 @default.
- W4313366070 hasRelatedWork W2056574647 @default.
- W4313366070 hasRelatedWork W2113243517 @default.
- W4313366070 hasRelatedWork W2164587311 @default.
- W4313366070 hasRelatedWork W2404833506 @default.
- W4313366070 hasVolume "202" @default.
- W4313366070 isParatext "false" @default.
- W4313366070 isRetracted "false" @default.
- W4313366070 workType "article" @default.