Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366082> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313366082 endingPage "63.2" @default.
- W4313366082 startingPage "63.2" @default.
- W4313366082 abstract "Abstract African Americans are four times more likely to develop kidney disease. Racial disparities in the frequency of nondiabetic kidney disease has led to the discovery of the apolipoprotein L1 (APOL1) gene variants, G1 and G2, which exist exclusively in individuals of recent African ancestry. The presence of these kidney risk alleles strongly correlates with several forms of nondiabetic kidney disease including lupus nephritis (LN). However, the mechanism by which APOL1 variants lead to a faster progression to LN in systemic lupus erythematosus (SLE) patients carrying APOL1 risk alleles is unclear. Increased levels of type I interferons (IFNs) and nucleosomal dsDNA fragments (nsDNA) in the blood is the hallmark of lupus erythematosus. We hypothesize that accumulation of dsDNA in the cytosol of podocytes that play a key role in maintenance of the filtration barrier in the kidney activates the DNA sensing pathways leading to expression of type I IFNs and proinflammatory cytokines damaging podocytes. Although type I IFNs stimulate APOL1 expression, it is unknown whether dsDNA induces APOL1 accumulation independently of IFN. Here we show that nsDNA triggers the expression of APOL1 through the activation of the cGAS/IFI16-STING-TBK1-IRF3 pathway. We have also shown that inhibition of type I IFN only partly inhibited APOL1 accumulation in podocytes, demonstrating that nsDNA directly activates expression of the APOL1 gene. We conclude that blocking type I IFN signaling and targeting elements of the nsDNA-induced pathway may represent a novel therapeutic approach to inhibit LN progression in African Americans SLE patients carrying APOL1 kidney risk alleles." @default.
- W4313366082 created "2023-01-06" @default.
- W4313366082 creator A5010739983 @default.
- W4313366082 creator A5075174305 @default.
- W4313366082 creator A5075950481 @default.
- W4313366082 date "2019-05-01" @default.
- W4313366082 modified "2023-09-26" @default.
- W4313366082 title "Nucleosomal double-stranded DNA triggers APOL1 expression through the STINGTBK1-IRF3 pathway" @default.
- W4313366082 doi "https://doi.org/10.4049/jimmunol.202.supp.63.2" @default.
- W4313366082 hasPublicationYear "2019" @default.
- W4313366082 type Work @default.
- W4313366082 citedByCount "0" @default.
- W4313366082 crossrefType "journal-article" @default.
- W4313366082 hasAuthorship W4313366082A5010739983 @default.
- W4313366082 hasAuthorship W4313366082A5075174305 @default.
- W4313366082 hasAuthorship W4313366082A5075950481 @default.
- W4313366082 hasConcept C104317684 @default.
- W4313366082 hasConcept C126322002 @default.
- W4313366082 hasConcept C134018914 @default.
- W4313366082 hasConcept C136449434 @default.
- W4313366082 hasConcept C164027704 @default.
- W4313366082 hasConcept C180754005 @default.
- W4313366082 hasConcept C203014093 @default.
- W4313366082 hasConcept C2776914184 @default.
- W4313366082 hasConcept C2778653478 @default.
- W4313366082 hasConcept C2779134260 @default.
- W4313366082 hasConcept C2779912601 @default.
- W4313366082 hasConcept C2780091579 @default.
- W4313366082 hasConcept C2780209191 @default.
- W4313366082 hasConcept C502942594 @default.
- W4313366082 hasConcept C54355233 @default.
- W4313366082 hasConcept C71924100 @default.
- W4313366082 hasConcept C86803240 @default.
- W4313366082 hasConcept C8891405 @default.
- W4313366082 hasConceptScore W4313366082C104317684 @default.
- W4313366082 hasConceptScore W4313366082C126322002 @default.
- W4313366082 hasConceptScore W4313366082C134018914 @default.
- W4313366082 hasConceptScore W4313366082C136449434 @default.
- W4313366082 hasConceptScore W4313366082C164027704 @default.
- W4313366082 hasConceptScore W4313366082C180754005 @default.
- W4313366082 hasConceptScore W4313366082C203014093 @default.
- W4313366082 hasConceptScore W4313366082C2776914184 @default.
- W4313366082 hasConceptScore W4313366082C2778653478 @default.
- W4313366082 hasConceptScore W4313366082C2779134260 @default.
- W4313366082 hasConceptScore W4313366082C2779912601 @default.
- W4313366082 hasConceptScore W4313366082C2780091579 @default.
- W4313366082 hasConceptScore W4313366082C2780209191 @default.
- W4313366082 hasConceptScore W4313366082C502942594 @default.
- W4313366082 hasConceptScore W4313366082C54355233 @default.
- W4313366082 hasConceptScore W4313366082C71924100 @default.
- W4313366082 hasConceptScore W4313366082C86803240 @default.
- W4313366082 hasConceptScore W4313366082C8891405 @default.
- W4313366082 hasIssue "1_Supplement" @default.
- W4313366082 hasLocation W43133660821 @default.
- W4313366082 hasOpenAccess W4313366082 @default.
- W4313366082 hasPrimaryLocation W43133660821 @default.
- W4313366082 hasRelatedWork W2001677368 @default.
- W4313366082 hasRelatedWork W2010403799 @default.
- W4313366082 hasRelatedWork W2120393042 @default.
- W4313366082 hasRelatedWork W2171277769 @default.
- W4313366082 hasRelatedWork W3003972077 @default.
- W4313366082 hasRelatedWork W4229019853 @default.
- W4313366082 hasRelatedWork W4255226035 @default.
- W4313366082 hasRelatedWork W4281700898 @default.
- W4313366082 hasRelatedWork W4309202722 @default.
- W4313366082 hasRelatedWork W1993930956 @default.
- W4313366082 hasVolume "202" @default.
- W4313366082 isParatext "false" @default.
- W4313366082 isRetracted "false" @default.
- W4313366082 workType "article" @default.