Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366083> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313366083 endingPage "135.12" @default.
- W4313366083 startingPage "135.12" @default.
- W4313366083 abstract "Abstract We have shown (Immunity 48:91–106, 2018) that a subset of murine monocytic precursor cells are plastic, and can up-regulate a Batf3-driven differentiation program resembling classical cDC1 cells. The resulting inflammatory DCs are important in tumor immunity, but it has been unclear whether they played a role in normal immune responses. We now identify the precursor cells for these inflammatory DCs as a population of Ly6c+ ckit+ c− fms+ CD11b-neg cells. These are constitutively present in all resting LNs (comprising up to half of the Ly6c+ cells). In response to a standard vaccination model of cross-presented antigen (whole OVA protein plus CpG adjuvant in IFA), the precursor cells rapidly up-regulated Batf3 and differentiated into CD103+ IRF8+ DCs. Just as in tumors, maturation was dependent on intracellular p53 signaling in the precursor cells. Targeted disruption of p53 (LysMcre/p53-KO) had no effect on the number of precursors, but abrogated their ability to mature into Batf3+ DCs. In KO mice, the loss of this single monocytic DC population entirely abrogated the ability to create an inflammatory milieu in the vaccine-draining LN, and abolished cross-presentation of protein antigen to T cells. In contrast, direct presentation (soluble siinfekl peptide) remained intact. We hypothesize that the ability of monocyte-lineage cells to differentiate into Batf3+ APCs during inflammation is an important component of the normal cross-presentation process." @default.
- W4313366083 created "2023-01-06" @default.
- W4313366083 creator A5008461707 @default.
- W4313366083 creator A5015771825 @default.
- W4313366083 date "2019-05-01" @default.
- W4313366083 modified "2023-09-26" @default.
- W4313366083 title "Monocyte-lineage dendritic cell (DC) precursors are pre-positioned in normal lymph nodes and rapidly differentiate into Batf3+ cross-presenting APCs during inflammation" @default.
- W4313366083 doi "https://doi.org/10.4049/jimmunol.202.supp.135.12" @default.
- W4313366083 hasPublicationYear "2019" @default.
- W4313366083 type Work @default.
- W4313366083 citedByCount "0" @default.
- W4313366083 crossrefType "journal-article" @default.
- W4313366083 hasAuthorship W4313366083A5008461707 @default.
- W4313366083 hasAuthorship W4313366083A5015771825 @default.
- W4313366083 hasConcept C124964019 @default.
- W4313366083 hasConcept C147483822 @default.
- W4313366083 hasConcept C1491633281 @default.
- W4313366083 hasConcept C203014093 @default.
- W4313366083 hasConcept C2776090121 @default.
- W4313366083 hasConcept C2776914184 @default.
- W4313366083 hasConcept C2778170410 @default.
- W4313366083 hasConcept C2778973524 @default.
- W4313366083 hasConcept C2781184567 @default.
- W4313366083 hasConcept C2908647359 @default.
- W4313366083 hasConcept C55493867 @default.
- W4313366083 hasConcept C67662055 @default.
- W4313366083 hasConcept C71924100 @default.
- W4313366083 hasConcept C83464605 @default.
- W4313366083 hasConcept C86803240 @default.
- W4313366083 hasConcept C8891405 @default.
- W4313366083 hasConcept C95444343 @default.
- W4313366083 hasConcept C99454951 @default.
- W4313366083 hasConceptScore W4313366083C124964019 @default.
- W4313366083 hasConceptScore W4313366083C147483822 @default.
- W4313366083 hasConceptScore W4313366083C1491633281 @default.
- W4313366083 hasConceptScore W4313366083C203014093 @default.
- W4313366083 hasConceptScore W4313366083C2776090121 @default.
- W4313366083 hasConceptScore W4313366083C2776914184 @default.
- W4313366083 hasConceptScore W4313366083C2778170410 @default.
- W4313366083 hasConceptScore W4313366083C2778973524 @default.
- W4313366083 hasConceptScore W4313366083C2781184567 @default.
- W4313366083 hasConceptScore W4313366083C2908647359 @default.
- W4313366083 hasConceptScore W4313366083C55493867 @default.
- W4313366083 hasConceptScore W4313366083C67662055 @default.
- W4313366083 hasConceptScore W4313366083C71924100 @default.
- W4313366083 hasConceptScore W4313366083C83464605 @default.
- W4313366083 hasConceptScore W4313366083C86803240 @default.
- W4313366083 hasConceptScore W4313366083C8891405 @default.
- W4313366083 hasConceptScore W4313366083C95444343 @default.
- W4313366083 hasConceptScore W4313366083C99454951 @default.
- W4313366083 hasIssue "1_Supplement" @default.
- W4313366083 hasLocation W43133660831 @default.
- W4313366083 hasOpenAccess W4313366083 @default.
- W4313366083 hasPrimaryLocation W43133660831 @default.
- W4313366083 hasRelatedWork W1911114680 @default.
- W4313366083 hasRelatedWork W1988789258 @default.
- W4313366083 hasRelatedWork W2036642444 @default.
- W4313366083 hasRelatedWork W2051822492 @default.
- W4313366083 hasRelatedWork W2072709441 @default.
- W4313366083 hasRelatedWork W2156596722 @default.
- W4313366083 hasRelatedWork W2178258247 @default.
- W4313366083 hasRelatedWork W2417773612 @default.
- W4313366083 hasRelatedWork W2546794527 @default.
- W4313366083 hasRelatedWork W2801179043 @default.
- W4313366083 hasVolume "202" @default.
- W4313366083 isParatext "false" @default.
- W4313366083 isRetracted "false" @default.
- W4313366083 workType "article" @default.