Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366088> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4313366088 endingPage "72.6" @default.
- W4313366088 startingPage "72.6" @default.
- W4313366088 abstract "Abstract Passive neutralizing antibody (NAb) infusion leads to a reduction of HIV plasma viremia in infected people as well as in SHIV-infected rhesus macaques. Potential mechanisms of viral reduction include neutralization of free virus as well as Fc-dependent effector functions that can clear infected cells. We generated several Fc variants of the human IgG1 NAb VRC07-523LS and characterized them for neutralization, complement binding, ADCC, phagocytosis, and binding to rhesus FcgR. Based on these assays, we down selected two variants, LALA and DEL, that showed knock-out or increase in ADCC and phagocytosis respectively, with complement binding knocked out in both. The parental, LALA and DEL variants of VRC07-523LS were administered at a single dose of 20 mg/kg i.v. to rhesus macaques chronically infected with SHIV-SF162P3 for 6–14 weeks (n=6 to 10 per group). Animals were followed for rate of plasma virus decay and antibody PK. All groups showed similar characteristics: 1) plasma virus decay was delayed for 24h after NAb infusion 2) the rate of plasma virus decay was the same between day 1 and day 5, and 3) plasma virus decay was independent of FcgRIII genotype. Pharmacokinetic analysis showed that serum NAb concentrations in the VRC07-523LS, LALA and DEL groups were maintained at greater than ten-fold excess of the in vitro IC80 against SHIV SF162P3 throughout the period of investigation. Further, unlike VRC07-523LS-LALA, VRC07-523LS-DEL was able to engage natural killer cells and monocytes and mediate both HIV envelope-dependent ADCC and phagocytosis. These results show that the initial impact on plasma viremia by passive NAb therapy is predominantly mediated by virus neutralization rather than ADCC or phagocytosis." @default.
- W4313366088 created "2023-01-06" @default.
- W4313366088 creator A5020230187 @default.
- W4313366088 creator A5025668076 @default.
- W4313366088 creator A5026415856 @default.
- W4313366088 creator A5027226086 @default.
- W4313366088 creator A5032312221 @default.
- W4313366088 creator A5035254739 @default.
- W4313366088 creator A5043225490 @default.
- W4313366088 creator A5044634194 @default.
- W4313366088 creator A5056797877 @default.
- W4313366088 creator A5057933126 @default.
- W4313366088 creator A5058338534 @default.
- W4313366088 creator A5067136189 @default.
- W4313366088 creator A5071657202 @default.
- W4313366088 creator A5071990559 @default.
- W4313366088 creator A5085278852 @default.
- W4313366088 creator A5087833005 @default.
- W4313366088 date "2019-05-01" @default.
- W4313366088 modified "2023-09-26" @default.
- W4313366088 title "Passive infusion of Fc-modified neutralizing antibodies does not affect the dynamics of plasma virus decay in SHIV-infected macaques" @default.
- W4313366088 doi "https://doi.org/10.4049/jimmunol.202.supp.72.6" @default.
- W4313366088 hasPublicationYear "2019" @default.
- W4313366088 type Work @default.
- W4313366088 citedByCount "0" @default.
- W4313366088 crossrefType "journal-article" @default.
- W4313366088 hasAuthorship W4313366088A5020230187 @default.
- W4313366088 hasAuthorship W4313366088A5025668076 @default.
- W4313366088 hasAuthorship W4313366088A5026415856 @default.
- W4313366088 hasAuthorship W4313366088A5027226086 @default.
- W4313366088 hasAuthorship W4313366088A5032312221 @default.
- W4313366088 hasAuthorship W4313366088A5035254739 @default.
- W4313366088 hasAuthorship W4313366088A5043225490 @default.
- W4313366088 hasAuthorship W4313366088A5044634194 @default.
- W4313366088 hasAuthorship W4313366088A5056797877 @default.
- W4313366088 hasAuthorship W4313366088A5057933126 @default.
- W4313366088 hasAuthorship W4313366088A5058338534 @default.
- W4313366088 hasAuthorship W4313366088A5067136189 @default.
- W4313366088 hasAuthorship W4313366088A5071657202 @default.
- W4313366088 hasAuthorship W4313366088A5071990559 @default.
- W4313366088 hasAuthorship W4313366088A5085278852 @default.
- W4313366088 hasAuthorship W4313366088A5087833005 @default.
- W4313366088 hasConcept C14086860 @default.
- W4313366088 hasConcept C159047783 @default.
- W4313366088 hasConcept C159654299 @default.
- W4313366088 hasConcept C160448771 @default.
- W4313366088 hasConcept C168507396 @default.
- W4313366088 hasConcept C185592680 @default.
- W4313366088 hasConcept C203014093 @default.
- W4313366088 hasConcept C2522874641 @default.
- W4313366088 hasConcept C2776185481 @default.
- W4313366088 hasConcept C2779261636 @default.
- W4313366088 hasConcept C40677261 @default.
- W4313366088 hasConcept C542903549 @default.
- W4313366088 hasConcept C86803240 @default.
- W4313366088 hasConcept C89372155 @default.
- W4313366088 hasConceptScore W4313366088C14086860 @default.
- W4313366088 hasConceptScore W4313366088C159047783 @default.
- W4313366088 hasConceptScore W4313366088C159654299 @default.
- W4313366088 hasConceptScore W4313366088C160448771 @default.
- W4313366088 hasConceptScore W4313366088C168507396 @default.
- W4313366088 hasConceptScore W4313366088C185592680 @default.
- W4313366088 hasConceptScore W4313366088C203014093 @default.
- W4313366088 hasConceptScore W4313366088C2522874641 @default.
- W4313366088 hasConceptScore W4313366088C2776185481 @default.
- W4313366088 hasConceptScore W4313366088C2779261636 @default.
- W4313366088 hasConceptScore W4313366088C40677261 @default.
- W4313366088 hasConceptScore W4313366088C542903549 @default.
- W4313366088 hasConceptScore W4313366088C86803240 @default.
- W4313366088 hasConceptScore W4313366088C89372155 @default.
- W4313366088 hasIssue "1_Supplement" @default.
- W4313366088 hasLocation W43133660881 @default.
- W4313366088 hasOpenAccess W4313366088 @default.
- W4313366088 hasPrimaryLocation W43133660881 @default.
- W4313366088 hasRelatedWork W1550873968 @default.
- W4313366088 hasRelatedWork W2020559014 @default.
- W4313366088 hasRelatedWork W2061271171 @default.
- W4313366088 hasRelatedWork W2139983200 @default.
- W4313366088 hasRelatedWork W2343368748 @default.
- W4313366088 hasRelatedWork W2591355966 @default.
- W4313366088 hasRelatedWork W3205340360 @default.
- W4313366088 hasRelatedWork W4205417207 @default.
- W4313366088 hasRelatedWork W4313308336 @default.
- W4313366088 hasRelatedWork W4313366088 @default.
- W4313366088 hasVolume "202" @default.
- W4313366088 isParatext "false" @default.
- W4313366088 isRetracted "false" @default.
- W4313366088 workType "article" @default.