Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366112> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313366112 endingPage "69.43" @default.
- W4313366112 startingPage "69.43" @default.
- W4313366112 abstract "Abstract Both donor and recipient hematopoietic cells regulate GvHD in allo-BMT, but the role of somatic host tissues in the induction and maintenance of GvHD is less clear. Vasoactive Intestinal peptide (VIP) is a neuropeptide with potent immune-regulatory activity. Our goal was to examine the role of VIP synthesis by recipient tissues on donor T cell activation and GvHD in allo-BMT. We used MHC mis-matched allo-BMT models, B10.BR-->B6 and Balb/c-->B6, irradiating WT and VIP-KO B6 mice with 11Gy on day −1 and transplanting with 5 × 10E6 T cell depleted (TCD) bone marrow (BM) plus 0, 1 × 10E6, or 3 × 10E6 T cells from MHC mis-matched donors. B6-->B6 radiation chimeras lacking VIP in either hematopoietic or non-hematopoietic cells were created by performing B6 WT-->VIP-KO and VIP-KO-->WT syngeneic transplants. Production of VIP in transplant recipients was visualized with immune-fluorescent staining of tissues using an anti-VIP antibody. Transplanting TCD BM plus 3 × 10E6 donor T cells from B10.BR or Balb/c donors in VIP KIO mice led significantly increased GVHD-mortality compared with WT recipients. Donor-derived T cells in VIP-KO recipients had significantly higher Th1 and Th17 polarization. B10.BR-->B6 second allogeneic transplantation of radiation chimeras caused lethal GVHD mortality in VIP-KO-- >VIP-KO and WT-->VIP-KO mice, but not in WT-->WT or VIP-KO-->WT B6 mice, demonstrating the protective effect of VIP was due to synthesis by somatic recipient cells. Immunofluorescent imaging of allo-BMT recipients showed up-regulation of VIP in lungs post-transplant and high VIP production within neurons innervating the lungs. Short-term administration of VIP from D0 to D10 prevented GvHD-mortality in VIP-KO recipients transplanted BM & T cells." @default.
- W4313366112 created "2023-01-06" @default.
- W4313366112 creator A5011386306 @default.
- W4313366112 creator A5031028550 @default.
- W4313366112 date "2019-05-01" @default.
- W4313366112 modified "2023-09-26" @default.
- W4313366112 title "Vasoactive intestinal polypeptide synthesis by somatic tissues in transplant recipients limits GVHD in allo-BMT" @default.
- W4313366112 doi "https://doi.org/10.4049/jimmunol.202.supp.69.43" @default.
- W4313366112 hasPublicationYear "2019" @default.
- W4313366112 type Work @default.
- W4313366112 citedByCount "0" @default.
- W4313366112 crossrefType "journal-article" @default.
- W4313366112 hasAuthorship W4313366112A5011386306 @default.
- W4313366112 hasAuthorship W4313366112A5031028550 @default.
- W4313366112 hasConcept C109159458 @default.
- W4313366112 hasConcept C118303440 @default.
- W4313366112 hasConcept C126322002 @default.
- W4313366112 hasConcept C134018914 @default.
- W4313366112 hasConcept C170493617 @default.
- W4313366112 hasConcept C185592680 @default.
- W4313366112 hasConcept C203014093 @default.
- W4313366112 hasConcept C2780007613 @default.
- W4313366112 hasConcept C28328180 @default.
- W4313366112 hasConcept C2911091166 @default.
- W4313366112 hasConcept C71924100 @default.
- W4313366112 hasConcept C8330315 @default.
- W4313366112 hasConcept C86803240 @default.
- W4313366112 hasConcept C8891405 @default.
- W4313366112 hasConcept C95444343 @default.
- W4313366112 hasConceptScore W4313366112C109159458 @default.
- W4313366112 hasConceptScore W4313366112C118303440 @default.
- W4313366112 hasConceptScore W4313366112C126322002 @default.
- W4313366112 hasConceptScore W4313366112C134018914 @default.
- W4313366112 hasConceptScore W4313366112C170493617 @default.
- W4313366112 hasConceptScore W4313366112C185592680 @default.
- W4313366112 hasConceptScore W4313366112C203014093 @default.
- W4313366112 hasConceptScore W4313366112C2780007613 @default.
- W4313366112 hasConceptScore W4313366112C28328180 @default.
- W4313366112 hasConceptScore W4313366112C2911091166 @default.
- W4313366112 hasConceptScore W4313366112C71924100 @default.
- W4313366112 hasConceptScore W4313366112C8330315 @default.
- W4313366112 hasConceptScore W4313366112C86803240 @default.
- W4313366112 hasConceptScore W4313366112C8891405 @default.
- W4313366112 hasConceptScore W4313366112C95444343 @default.
- W4313366112 hasIssue "1_Supplement" @default.
- W4313366112 hasLocation W43133661121 @default.
- W4313366112 hasOpenAccess W4313366112 @default.
- W4313366112 hasPrimaryLocation W43133661121 @default.
- W4313366112 hasRelatedWork W1966638871 @default.
- W4313366112 hasRelatedWork W1995680439 @default.
- W4313366112 hasRelatedWork W2016408069 @default.
- W4313366112 hasRelatedWork W2016899150 @default.
- W4313366112 hasRelatedWork W2027568289 @default.
- W4313366112 hasRelatedWork W2030613578 @default.
- W4313366112 hasRelatedWork W2030890948 @default.
- W4313366112 hasRelatedWork W2084109973 @default.
- W4313366112 hasRelatedWork W2132497793 @default.
- W4313366112 hasRelatedWork W2137290576 @default.
- W4313366112 hasVolume "202" @default.
- W4313366112 isParatext "false" @default.
- W4313366112 isRetracted "false" @default.
- W4313366112 workType "article" @default.