Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366114> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313366114 endingPage "133.8" @default.
- W4313366114 startingPage "133.8" @default.
- W4313366114 abstract "Abstract Objectives To explore the molecular mechanisms in which vitamin D (VD) regulates T cells, especially Th17 cells in collagen-induced arthritis (CIA). Methods DBA1/J mice induced for CIA were intraperitoneally treated with VD. CIA clinical symptoms and inflammatory responses including Th1/Th17/Tregs percentages were determined and compared. Mouse naïve CD4+ T cells transduced with miR-124 inhibitor or not were polarized to Th17 cells with or without VD. Subsequently, cellular differentiation and IL-6 signaling moleculars were analyzed. Results VD treatment significantly delayed CIA onset, decreased incidence and clinical scores of arthritis, downregulated serum IgG levels and ameliorated bone erosion. VD downregulated IL-17A production in CD4+ T cells while increased CD4+Foxp3+Nrp-1+ cells both in draining lymph nodes and synovial fluid in arthritic mice. VD inhibited Th17 cells differentiation in vivo and in vitro and potentially functioning directly on T cells to restrain Th17 cells through limiting IL-6R expression and its downstream signaling including STAT3 phosphorylation, while these effects were blocked when naïve CD4+ T cells were transduced with miR-124 inhibitor. Conclusions VD treatment ameliorates CIA via suppression of Th17 cells and enhancement of Tregs. miR-124-mediated inhibition of IL-6 signaling, provides a novel explanation for VD’s role on T cells in CIA mice or RA patients and suggests that VD may have treatment implications in rheumatoid arthritis." @default.
- W4313366114 created "2023-01-06" @default.
- W4313366114 creator A5031674948 @default.
- W4313366114 creator A5074402502 @default.
- W4313366114 creator A5084541609 @default.
- W4313366114 date "2019-05-01" @default.
- W4313366114 modified "2023-10-16" @default.
- W4313366114 title "1,25-Dihydroxyvitamin D3 ameliorates collagen-induced arthritis <i>via</i> suppression of Th17 cells through miR-124 mediated inhibition of IL-6 signaling" @default.
- W4313366114 doi "https://doi.org/10.4049/jimmunol.202.supp.133.8" @default.
- W4313366114 hasPublicationYear "2019" @default.
- W4313366114 type Work @default.
- W4313366114 citedByCount "0" @default.
- W4313366114 crossrefType "journal-article" @default.
- W4313366114 hasAuthorship W4313366114A5031674948 @default.
- W4313366114 hasAuthorship W4313366114A5074402502 @default.
- W4313366114 hasAuthorship W4313366114A5084541609 @default.
- W4313366114 hasBestOaLocation W43133661142 @default.
- W4313366114 hasConcept C126322002 @default.
- W4313366114 hasConcept C134018914 @default.
- W4313366114 hasConcept C185592680 @default.
- W4313366114 hasConcept C203014093 @default.
- W4313366114 hasConcept C2776914184 @default.
- W4313366114 hasConcept C2777077863 @default.
- W4313366114 hasConcept C2777575956 @default.
- W4313366114 hasConcept C2779727006 @default.
- W4313366114 hasConcept C47348012 @default.
- W4313366114 hasConcept C502942594 @default.
- W4313366114 hasConcept C71924100 @default.
- W4313366114 hasConcept C86803240 @default.
- W4313366114 hasConcept C8891405 @default.
- W4313366114 hasConcept C95444343 @default.
- W4313366114 hasConceptScore W4313366114C126322002 @default.
- W4313366114 hasConceptScore W4313366114C134018914 @default.
- W4313366114 hasConceptScore W4313366114C185592680 @default.
- W4313366114 hasConceptScore W4313366114C203014093 @default.
- W4313366114 hasConceptScore W4313366114C2776914184 @default.
- W4313366114 hasConceptScore W4313366114C2777077863 @default.
- W4313366114 hasConceptScore W4313366114C2777575956 @default.
- W4313366114 hasConceptScore W4313366114C2779727006 @default.
- W4313366114 hasConceptScore W4313366114C47348012 @default.
- W4313366114 hasConceptScore W4313366114C502942594 @default.
- W4313366114 hasConceptScore W4313366114C71924100 @default.
- W4313366114 hasConceptScore W4313366114C86803240 @default.
- W4313366114 hasConceptScore W4313366114C8891405 @default.
- W4313366114 hasConceptScore W4313366114C95444343 @default.
- W4313366114 hasIssue "1_Supplement" @default.
- W4313366114 hasLocation W43133661141 @default.
- W4313366114 hasLocation W43133661142 @default.
- W4313366114 hasOpenAccess W4313366114 @default.
- W4313366114 hasPrimaryLocation W43133661141 @default.
- W4313366114 hasRelatedWork W1569971301 @default.
- W4313366114 hasRelatedWork W1997714882 @default.
- W4313366114 hasRelatedWork W2018318055 @default.
- W4313366114 hasRelatedWork W2049680503 @default.
- W4313366114 hasRelatedWork W2102812553 @default.
- W4313366114 hasRelatedWork W2134592607 @default.
- W4313366114 hasRelatedWork W2165908110 @default.
- W4313366114 hasRelatedWork W2338134927 @default.
- W4313366114 hasRelatedWork W2441992926 @default.
- W4313366114 hasRelatedWork W2748952813 @default.
- W4313366114 hasVolume "202" @default.
- W4313366114 isParatext "false" @default.
- W4313366114 isRetracted "false" @default.
- W4313366114 workType "article" @default.