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- W4313366116 abstract "Abstract Viruses that cause chronic infections, including Human Immunodeficiency Virus (HIV), Hepatitis B virus (HBV), and Hepatitis C virus (HCV), infect more than 500 million people worldwide and represent a major health burden. Chronic viral infections suppress immune responses to promote their own persistence. Plasmacytoid Dendritic Cells (pDCs) are an innate cell type which are specialized to produce exceptionally high levels of type I interferon (IFN-I) in response to viral infection, however in the context of chronic viral infection they lose the capacity to produce IFN-I. The metabolic program of pDCs has previously been implicated to be crucial for their function, but it is unclear how chronic infection modifies pDC metabolism. We demonstrate that chronic infection stimulates metabolic reprogramming in pDCs. Specifically, chronic infection is associated with sustained suppression of respiratory metabolism in pDCs. Furthermore, we demonstrate that respiratory metabolism in pDCs is highly correlated to their ability to produce cytokine, and that byproducts of respiratory metabolism (mitochondrial derived reactive oxygen species) can promote cytokine production in pDCs. These data suggest that chronic infection drives changes in pDC metabolism that could be associated with infection driven pDC exhaustion." @default.
- W4313366116 created "2023-01-06" @default.
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- W4313366116 date "2019-05-01" @default.
- W4313366116 modified "2023-09-26" @default.
- W4313366116 title "Chronic Viral Infection Induces Metabolic Reprograming of Plasmacytoid Dendritic Cells" @default.
- W4313366116 doi "https://doi.org/10.4049/jimmunol.202.supp.187.28" @default.
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