Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366122> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4313366122 endingPage "66.21" @default.
- W4313366122 startingPage "66.21" @default.
- W4313366122 abstract "Abstract Migratory dynamics of T cells influence outcomes of infections and cancer. This study addresses how CD4+ T cell immunosurveillance strategies compare to CD8+ T cells by analyzing migration, transcriptome, phenotype, and function. After acute viral infection, memory CD4+ T cells predominantly utilized residence to survey nonlymphoid tissues, albeit not as stringently as observed for CD8+ T cells. In contrast, memory CD4+ T cells were more likely to be resident within lymphoid organs than CD8+ T cells. Migration properties of memory-phenotype CD4+ T cells in non-SPF parabionts were similar, generalizing these results to diverse infections and conditions. CD4+ and CD8+ resident memory T cells (TRM) shared overlapping transcriptional signatures and location-specific features, such as granzyme B expression in the small intestine, revealing tissue-specific and migration property-specific, in addition to lineage-specific, differentiation programs. Functionally, mucosal CD4+ TRM reactivation locally triggered both chemokine expression and broad immune cell activation. Thus, residence provides a dominant mechanism for regionalizing CD4+ T cell immunity, and location enforces shared transcriptional, phenotypic, and functional properties with CD8+ T cells." @default.
- W4313366122 created "2023-01-06" @default.
- W4313366122 creator A5008502758 @default.
- W4313366122 creator A5014214867 @default.
- W4313366122 creator A5023307555 @default.
- W4313366122 creator A5026368461 @default.
- W4313366122 creator A5050735501 @default.
- W4313366122 creator A5051921473 @default.
- W4313366122 creator A5056109558 @default.
- W4313366122 creator A5075967644 @default.
- W4313366122 creator A5081469068 @default.
- W4313366122 date "2019-05-01" @default.
- W4313366122 modified "2023-09-26" @default.
- W4313366122 title "CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses" @default.
- W4313366122 doi "https://doi.org/10.4049/jimmunol.202.supp.66.21" @default.
- W4313366122 hasPublicationYear "2019" @default.
- W4313366122 type Work @default.
- W4313366122 citedByCount "0" @default.
- W4313366122 crossrefType "journal-article" @default.
- W4313366122 hasAuthorship W4313366122A5008502758 @default.
- W4313366122 hasAuthorship W4313366122A5014214867 @default.
- W4313366122 hasAuthorship W4313366122A5023307555 @default.
- W4313366122 hasAuthorship W4313366122A5026368461 @default.
- W4313366122 hasAuthorship W4313366122A5050735501 @default.
- W4313366122 hasAuthorship W4313366122A5051921473 @default.
- W4313366122 hasAuthorship W4313366122A5056109558 @default.
- W4313366122 hasAuthorship W4313366122A5075967644 @default.
- W4313366122 hasAuthorship W4313366122A5081469068 @default.
- W4313366122 hasConcept C104317684 @default.
- W4313366122 hasConcept C127716648 @default.
- W4313366122 hasConcept C150194340 @default.
- W4313366122 hasConcept C154317977 @default.
- W4313366122 hasConcept C162317418 @default.
- W4313366122 hasConcept C167672396 @default.
- W4313366122 hasConcept C202751555 @default.
- W4313366122 hasConcept C203014093 @default.
- W4313366122 hasConcept C2776090121 @default.
- W4313366122 hasConcept C2776885095 @default.
- W4313366122 hasConcept C2780380082 @default.
- W4313366122 hasConcept C54355233 @default.
- W4313366122 hasConcept C86803240 @default.
- W4313366122 hasConcept C8891405 @default.
- W4313366122 hasConcept C95444343 @default.
- W4313366122 hasConceptScore W4313366122C104317684 @default.
- W4313366122 hasConceptScore W4313366122C127716648 @default.
- W4313366122 hasConceptScore W4313366122C150194340 @default.
- W4313366122 hasConceptScore W4313366122C154317977 @default.
- W4313366122 hasConceptScore W4313366122C162317418 @default.
- W4313366122 hasConceptScore W4313366122C167672396 @default.
- W4313366122 hasConceptScore W4313366122C202751555 @default.
- W4313366122 hasConceptScore W4313366122C203014093 @default.
- W4313366122 hasConceptScore W4313366122C2776090121 @default.
- W4313366122 hasConceptScore W4313366122C2776885095 @default.
- W4313366122 hasConceptScore W4313366122C2780380082 @default.
- W4313366122 hasConceptScore W4313366122C54355233 @default.
- W4313366122 hasConceptScore W4313366122C86803240 @default.
- W4313366122 hasConceptScore W4313366122C8891405 @default.
- W4313366122 hasConceptScore W4313366122C95444343 @default.
- W4313366122 hasIssue "1_Supplement" @default.
- W4313366122 hasLocation W43133661221 @default.
- W4313366122 hasOpenAccess W4313366122 @default.
- W4313366122 hasPrimaryLocation W43133661221 @default.
- W4313366122 hasRelatedWork W1979001884 @default.
- W4313366122 hasRelatedWork W2123317146 @default.
- W4313366122 hasRelatedWork W2153797564 @default.
- W4313366122 hasRelatedWork W2413098560 @default.
- W4313366122 hasRelatedWork W2981642747 @default.
- W4313366122 hasRelatedWork W4220786134 @default.
- W4313366122 hasRelatedWork W4282561649 @default.
- W4313366122 hasRelatedWork W4286560817 @default.
- W4313366122 hasRelatedWork W91094769 @default.
- W4313366122 hasRelatedWork W2181857777 @default.
- W4313366122 hasVolume "202" @default.
- W4313366122 isParatext "false" @default.
- W4313366122 isRetracted "false" @default.
- W4313366122 workType "article" @default.