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- W4313366133 abstract "Abstract Mucosal-associated invariant T (MAIT) cells are a novel subpopulation of innate-like T lymphocytes that recognize vitamin B metabolites and express an invariant T cell receptor (TCR) α chain. MAIT cells are less abundant in mouse blood (~0.1% of T cells) as compared to human blood (~5%). MAIT cells play an important role in various infectious non-infectious diseases. Given their small number in mouse, these cells have been not been fully characterized. To unravel MAIT cell heterogeneity in thymus and peripheral tissues, we have performed single-cell sequencing of MAIT cells from various organs using 10× single-cell genomics, where we sequenced more than 7,000 cells and identified 10 clusters of MAIT cells by unbiased clustering. Cells from different organs mostly are represented in the different clusters, except one cluster was lung MAIT cell specific and another cluster consisted of cells exclusively from thymus. The lung specific cluster also reveals a tissue residency gene signature. We compared the gene expression profile of MAIT cells with iNKT cells, another T lymphocyte population that recognizes non-peptide antigens with invariant α chains. Our data reveal that most mouse MAIT cells have a Th17/NKT17–like gene signature, although there are some with Th1/NKT1 like transcriptomes, particularly in liver and spleen. A Th2/NKT2 gene expression profile was not observed. The thymus specific cluster showed a gene expression profile similar to the most immature or progenitor iNKT cells (NKT0), consistent with other data suggesting a unique thymus differentiation pathway. Therefore, our study reveals that although MAIT cells are predominantly Th17 and Th1 cells, there is an unexpected degree of heterogeneity. Supported by R01 AI71922" @default.
- W4313366133 created "2023-01-06" @default.
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- W4313366133 date "2019-05-01" @default.
- W4313366133 modified "2023-09-26" @default.
- W4313366133 title "Single cell sequencing reveals mouse MAIT cell diversity" @default.
- W4313366133 doi "https://doi.org/10.4049/jimmunol.202.supp.65.1" @default.
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