Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366184> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4313366184 endingPage "134.12" @default.
- W4313366184 startingPage "134.12" @default.
- W4313366184 abstract "Abstract NK cells participate in the innate immune response against infection and cancer without prior sensitization. NK cell function depends on a balance of signals transmitted from activating and inhibitory receptors interacting with ligands on the surface of cells. Cancer cells may evade NK-mediated killing by expressing ligands for inhibitory receptors. Proliferating cell nuclear antigen (PCNA) associates with MHC I and forms the inhibitory ligand for NKp44, resulting in the inhibition of NK function. Cancer stem cells (CSC), a unique subset of tumor cells, possess a stem-cell-like phenotype and are thought to facilitate metastasis by escaping NK cell effector function. Pancreatic and colon CSC can be identified by co-expression of surface markers CD44 and CD133. In both cell lines, Panc-1 and HCT 116, cell surface PCNA is associated with co-expression of CD44 and CD133 as well as increased CSC transcription factor expression (NANOG, SOX2, and Oct-4). Blocking the interaction of NKp44 and PCNA enhanced the specific lysis of cells by NK cells. Collectively these data demonstrate that surface PCNA, CD44, and CD133 co-expression is a marker of pancreatic and colon CSC. Our research implicates that blocking NKp44-PCNA interaction may provide a novel immunotherapeutic target for pancreatic and colon cancer stem cells and prevent metastasis." @default.
- W4313366184 created "2023-01-06" @default.
- W4313366184 creator A5008670026 @default.
- W4313366184 creator A5067008857 @default.
- W4313366184 date "2019-05-01" @default.
- W4313366184 modified "2023-09-26" @default.
- W4313366184 title "Cancer stem cells inhibit NK cell effector function via PCNA-NKp44 interaction" @default.
- W4313366184 doi "https://doi.org/10.4049/jimmunol.202.supp.134.12" @default.
- W4313366184 hasPublicationYear "2019" @default.
- W4313366184 type Work @default.
- W4313366184 citedByCount "0" @default.
- W4313366184 crossrefType "journal-article" @default.
- W4313366184 hasAuthorship W4313366184A5008670026 @default.
- W4313366184 hasAuthorship W4313366184A5067008857 @default.
- W4313366184 hasConcept C104317684 @default.
- W4313366184 hasConcept C121608353 @default.
- W4313366184 hasConcept C1491633281 @default.
- W4313366184 hasConcept C185592680 @default.
- W4313366184 hasConcept C2777933648 @default.
- W4313366184 hasConcept C2779013556 @default.
- W4313366184 hasConcept C2780932548 @default.
- W4313366184 hasConcept C28328180 @default.
- W4313366184 hasConcept C502942594 @default.
- W4313366184 hasConcept C51785407 @default.
- W4313366184 hasConcept C54355233 @default.
- W4313366184 hasConcept C55427017 @default.
- W4313366184 hasConcept C55493867 @default.
- W4313366184 hasConcept C86339819 @default.
- W4313366184 hasConcept C86803240 @default.
- W4313366184 hasConcept C95444343 @default.
- W4313366184 hasConcept C96232424 @default.
- W4313366184 hasConceptScore W4313366184C104317684 @default.
- W4313366184 hasConceptScore W4313366184C121608353 @default.
- W4313366184 hasConceptScore W4313366184C1491633281 @default.
- W4313366184 hasConceptScore W4313366184C185592680 @default.
- W4313366184 hasConceptScore W4313366184C2777933648 @default.
- W4313366184 hasConceptScore W4313366184C2779013556 @default.
- W4313366184 hasConceptScore W4313366184C2780932548 @default.
- W4313366184 hasConceptScore W4313366184C28328180 @default.
- W4313366184 hasConceptScore W4313366184C502942594 @default.
- W4313366184 hasConceptScore W4313366184C51785407 @default.
- W4313366184 hasConceptScore W4313366184C54355233 @default.
- W4313366184 hasConceptScore W4313366184C55427017 @default.
- W4313366184 hasConceptScore W4313366184C55493867 @default.
- W4313366184 hasConceptScore W4313366184C86339819 @default.
- W4313366184 hasConceptScore W4313366184C86803240 @default.
- W4313366184 hasConceptScore W4313366184C95444343 @default.
- W4313366184 hasConceptScore W4313366184C96232424 @default.
- W4313366184 hasIssue "1_Supplement" @default.
- W4313366184 hasLocation W43133661841 @default.
- W4313366184 hasOpenAccess W4313366184 @default.
- W4313366184 hasPrimaryLocation W43133661841 @default.
- W4313366184 hasRelatedWork W1539977954 @default.
- W4313366184 hasRelatedWork W2090487408 @default.
- W4313366184 hasRelatedWork W2132960500 @default.
- W4313366184 hasRelatedWork W2520492110 @default.
- W4313366184 hasRelatedWork W2568740110 @default.
- W4313366184 hasRelatedWork W2980552249 @default.
- W4313366184 hasRelatedWork W3008610168 @default.
- W4313366184 hasRelatedWork W3108889493 @default.
- W4313366184 hasRelatedWork W3127467593 @default.
- W4313366184 hasRelatedWork W4378193825 @default.
- W4313366184 hasVolume "202" @default.
- W4313366184 isParatext "false" @default.
- W4313366184 isRetracted "false" @default.
- W4313366184 workType "article" @default.