Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366187> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4313366187 endingPage "63.8" @default.
- W4313366187 startingPage "63.8" @default.
- W4313366187 abstract "Abstract The NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate NLRP3 is unknown. Here we show that different NLRP3 stimuli lead to disassembly of the trans-Golgi network (TGN). NLRP3 is recruited to the dispersed TGN (dTGN) through ionic bonding between its conserved polybasic region and negatively charged phosphatidylinositol-4-phosphate (PtdIns4P) on the dTGN. The dTGN then serves as a scaffold for NLRP3 aggregation into multiple puncta, leading to polymerization of the adaptor protein ASC, thereby activating the downstream signalling cascade. Disruption of the interaction between NLRP3 and PtdIns4P on the dTGN blocked NLRP3 aggregation and downstream signalling. These results indicate that recruitment of NLRP3 to dTGN is an early and common cellular event that leads to NLRP3 aggregation and activation in response to diverse stimuli." @default.
- W4313366187 created "2023-01-06" @default.
- W4313366187 creator A5000591490 @default.
- W4313366187 creator A5036087104 @default.
- W4313366187 date "2019-05-01" @default.
- W4313366187 modified "2023-09-26" @default.
- W4313366187 title "PtdIns4P on dispersed <i>trans</i>-Golgi network mediates NLRP3 inflammasome activation" @default.
- W4313366187 doi "https://doi.org/10.4049/jimmunol.202.supp.63.8" @default.
- W4313366187 hasPublicationYear "2019" @default.
- W4313366187 type Work @default.
- W4313366187 citedByCount "0" @default.
- W4313366187 crossrefType "journal-article" @default.
- W4313366187 hasAuthorship W4313366187A5000591490 @default.
- W4313366187 hasAuthorship W4313366187A5036087104 @default.
- W4313366187 hasConcept C119062480 @default.
- W4313366187 hasConcept C12554922 @default.
- W4313366187 hasConcept C139174496 @default.
- W4313366187 hasConcept C158617107 @default.
- W4313366187 hasConcept C170493617 @default.
- W4313366187 hasConcept C183786373 @default.
- W4313366187 hasConcept C185592680 @default.
- W4313366187 hasConcept C2777209026 @default.
- W4313366187 hasConcept C55493867 @default.
- W4313366187 hasConcept C62478195 @default.
- W4313366187 hasConcept C86803240 @default.
- W4313366187 hasConcept C95444343 @default.
- W4313366187 hasConceptScore W4313366187C119062480 @default.
- W4313366187 hasConceptScore W4313366187C12554922 @default.
- W4313366187 hasConceptScore W4313366187C139174496 @default.
- W4313366187 hasConceptScore W4313366187C158617107 @default.
- W4313366187 hasConceptScore W4313366187C170493617 @default.
- W4313366187 hasConceptScore W4313366187C183786373 @default.
- W4313366187 hasConceptScore W4313366187C185592680 @default.
- W4313366187 hasConceptScore W4313366187C2777209026 @default.
- W4313366187 hasConceptScore W4313366187C55493867 @default.
- W4313366187 hasConceptScore W4313366187C62478195 @default.
- W4313366187 hasConceptScore W4313366187C86803240 @default.
- W4313366187 hasConceptScore W4313366187C95444343 @default.
- W4313366187 hasIssue "1_Supplement" @default.
- W4313366187 hasLocation W43133661871 @default.
- W4313366187 hasOpenAccess W4313366187 @default.
- W4313366187 hasPrimaryLocation W43133661871 @default.
- W4313366187 hasRelatedWork W1968305129 @default.
- W4313366187 hasRelatedWork W2037270713 @default.
- W4313366187 hasRelatedWork W2059381041 @default.
- W4313366187 hasRelatedWork W2749339966 @default.
- W4313366187 hasRelatedWork W3185847673 @default.
- W4313366187 hasRelatedWork W3197589628 @default.
- W4313366187 hasRelatedWork W4213451181 @default.
- W4313366187 hasRelatedWork W4221042364 @default.
- W4313366187 hasRelatedWork W4225107307 @default.
- W4313366187 hasRelatedWork W4310367351 @default.
- W4313366187 hasVolume "202" @default.
- W4313366187 isParatext "false" @default.
- W4313366187 isRetracted "false" @default.
- W4313366187 workType "article" @default.