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- W4313366193 abstract "Abstract Virtual memory T (TVM) cells are antigen-naïve CD8 T cell cells that exist in a semi-differentiated state. They exhibit some characteristics that are classically associated with conventional memory T cells (TMEM), including elevated expression of CD44, accelerated TCR-driven proliferation, and enhanced cytokine responsiveness. Despite rapid and robust proliferation of young TVM cells after TCR-mediated stimulation, aged TVM cells exhibit marked proliferative dysfunction. Recently, high spare respiratory capacity (SRC) was proposed as a defining metabolic characteristic of antigen-experienced memory T cells (TMEM) cells, thought to promote both their longevity and rapid functionality. Given the semi-differentated state of TVM cells, we sought to determine whether the SRC of TVM cells also corresponded to their longevity and functionality. Surprisingly, we found that elevated SRC was a feature of TVM cells, but not TMEM cells, and that SRC increased substantially with age in both subsets, repudiating a link between SRC and functionality. We further showed that SRC was closely linked with responsiveness to IL-15, since TVM cells alone were dependent on IL-15 for survival/accumulation, and showed increased receptor (CD122) expression, and IL-15 mediated STAT5 phosphorylation. Moreover, recent infection caused an increase in SRC in TVM cells but inhibition of IL-15 during infection was sufficient to prevent this increase. Collectively, these findings indicate that elevated SRC is a feature of TVM and not TMEM cells and is a consequence of their heightened IL-15 sensitivity. Moreover, elevated SRC is not associated with T cell functionality in young or aged cells, but may be associated with survival of TVM cells." @default.
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- W4313366193 date "2019-05-01" @default.
- W4313366193 modified "2023-10-16" @default.
- W4313366193 title "High Spare Respiratory Capacity is a Canonical Feature of Virtual Memory, but not Conventional Memory CD8 T Cells, and is Driven by IL-15 Signalling" @default.
- W4313366193 doi "https://doi.org/10.4049/jimmunol.202.supp.60.7" @default.
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