Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366204> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313366204 endingPage "75.18" @default.
- W4313366204 startingPage "75.18" @default.
- W4313366204 abstract "Abstract Smallpox, caused by infection with variola virus, led to devastating human pandemics with high mortality until eradication through a global vaccination campaign. Despite eradication, the precise immune mechanisms underlying recovery from infection are incompletely understood. The most common model employed to study smallpox is murine infection with vaccinia virus (VACV), the virus used for human smallpox vaccination. VACV models of smallpox infection commonly employ intranasal or even intravenous routes of infection, with both resulting in widespread viral dissemination. However, variola virus infected humans through the oropharyngeal mucosa, after which oral lesions developed and ruptured, spilling copious infectious virus into the saliva (the route of human-to-human spread). To understand protection in this critical barrier site, we developed a mouse model of lip (labial mucosal) infection. After labial administration, VACV replicates to high titers and two waves of group I innate lymphoid cells (ILCs) are recruited in response to infection. Intravital imaging revealed highly mobile ILCs in the oral mucosa, most of which failed to contact virus-infected cells. Despite the lack of stable contacts, depletion of NK1.1+ cells enhanced viral replication and spread. Instead, ILCs delivered IFN-γ to the mucosal tissue, inducing an antiviral signature in the epithelium. Together, these data illustrate the complex nature of immune protection in a critical yet overlooked tissue during viral pathogenesis." @default.
- W4313366204 created "2023-01-06" @default.
- W4313366204 creator A5014015685 @default.
- W4313366204 creator A5034626582 @default.
- W4313366204 creator A5047433549 @default.
- W4313366204 creator A5071724455 @default.
- W4313366204 creator A5071933041 @default.
- W4313366204 date "2019-05-01" @default.
- W4313366204 modified "2023-09-26" @default.
- W4313366204 title "Patrolling ILCs restrain mucosal viral replication through tissue-wide delivery of IFN-γ" @default.
- W4313366204 doi "https://doi.org/10.4049/jimmunol.202.supp.75.18" @default.
- W4313366204 hasPublicationYear "2019" @default.
- W4313366204 type Work @default.
- W4313366204 citedByCount "0" @default.
- W4313366204 crossrefType "journal-article" @default.
- W4313366204 hasAuthorship W4313366204A5014015685 @default.
- W4313366204 hasAuthorship W4313366204A5034626582 @default.
- W4313366204 hasAuthorship W4313366204A5047433549 @default.
- W4313366204 hasAuthorship W4313366204A5071724455 @default.
- W4313366204 hasAuthorship W4313366204A5071933041 @default.
- W4313366204 hasConcept C104317684 @default.
- W4313366204 hasConcept C140704245 @default.
- W4313366204 hasConcept C159047783 @default.
- W4313366204 hasConcept C203014093 @default.
- W4313366204 hasConcept C22070199 @default.
- W4313366204 hasConcept C2522874641 @default.
- W4313366204 hasConcept C2778417375 @default.
- W4313366204 hasConcept C2779094796 @default.
- W4313366204 hasConcept C2779272165 @default.
- W4313366204 hasConcept C2781356689 @default.
- W4313366204 hasConcept C2909788366 @default.
- W4313366204 hasConcept C40767141 @default.
- W4313366204 hasConcept C55493867 @default.
- W4313366204 hasConcept C86803240 @default.
- W4313366204 hasConcept C8891405 @default.
- W4313366204 hasConceptScore W4313366204C104317684 @default.
- W4313366204 hasConceptScore W4313366204C140704245 @default.
- W4313366204 hasConceptScore W4313366204C159047783 @default.
- W4313366204 hasConceptScore W4313366204C203014093 @default.
- W4313366204 hasConceptScore W4313366204C22070199 @default.
- W4313366204 hasConceptScore W4313366204C2522874641 @default.
- W4313366204 hasConceptScore W4313366204C2778417375 @default.
- W4313366204 hasConceptScore W4313366204C2779094796 @default.
- W4313366204 hasConceptScore W4313366204C2779272165 @default.
- W4313366204 hasConceptScore W4313366204C2781356689 @default.
- W4313366204 hasConceptScore W4313366204C2909788366 @default.
- W4313366204 hasConceptScore W4313366204C40767141 @default.
- W4313366204 hasConceptScore W4313366204C55493867 @default.
- W4313366204 hasConceptScore W4313366204C86803240 @default.
- W4313366204 hasConceptScore W4313366204C8891405 @default.
- W4313366204 hasIssue "1_Supplement" @default.
- W4313366204 hasLocation W43133662041 @default.
- W4313366204 hasOpenAccess W4313366204 @default.
- W4313366204 hasPrimaryLocation W43133662041 @default.
- W4313366204 hasRelatedWork W1984263551 @default.
- W4313366204 hasRelatedWork W2017353156 @default.
- W4313366204 hasRelatedWork W2054789512 @default.
- W4313366204 hasRelatedWork W2089101317 @default.
- W4313366204 hasRelatedWork W2112575263 @default.
- W4313366204 hasRelatedWork W2134161715 @default.
- W4313366204 hasRelatedWork W2168065688 @default.
- W4313366204 hasRelatedWork W2395455967 @default.
- W4313366204 hasRelatedWork W2471881110 @default.
- W4313366204 hasRelatedWork W4238546509 @default.
- W4313366204 hasVolume "202" @default.
- W4313366204 isParatext "false" @default.
- W4313366204 isRetracted "false" @default.
- W4313366204 workType "article" @default.