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- W4313366220 abstract "Abstract The aim of this study was to examine short-term and long-term effects of early administration of two dietary oligosaccharide supplements, fructooligosaccharide (FOS) and galactooligosaccharide (GOS) on innate immune parameters in infant Wistar rats. A second aim was to compare the impact of these supplements between sexes. Infant rats were gavaged orally on post natal days (PND) 6–16 with either FOS or GOS solution (0.075 g/50 μL), or with glucose (0.375 g/50 μL) or no gavage as controls while being maintained on an AIN-93G diet post-weaning (n = 8 per treatment/sex). Immune impacts at PND-16 and PND-70 were determined by immunophenotyping via flow cytometry and analyses of whole blood ex vivo TLR ligand responses at PND-70. At PND-16, percentages of CD103+ Dendritic cells (DC) were higher in MLN (P < 0.003) and spleens (P < 0.008) of FOS-treated rats (P < 0.003). At PND-70, CD103+ were unaffected but FOS supplementation had differential effects on MLN and spleen γδ-T cell populations in females versus males. Unstimulated whole blood cultures from rats fed GOS produced less CINC-1 than other treatments (P < 0.02, 57.5 ± 21.6 pg/mL). GOS-fed rats also had lower CINC-1 production in response to TLR2 (Pam3Cys, P < 0.02) and TLR4 (lipopolysaccharide, P < 0.01) stimulation, and produced less IL-1β after TLR4 stimulation (P < 0.05) than rats from all other treatments. Males produced more IL-10 than females after TLR4 stimulation regardless of treatment (P < 0.001, 72.6 ± 11.6 vs. 40.9 ± 8.2 pg/mL). Overall, these results suggest limited impact of early administration of prebiotic supplements FOS and GOS on immune development, with GOS having some long-term potential to modulate TLR2 and TLR4 ligand responses." @default.
- W4313366220 created "2023-01-06" @default.
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- W4313366220 date "2019-05-01" @default.
- W4313366220 modified "2023-09-30" @default.
- W4313366220 title "Short- and long-term impact of prebiotic supplementation during infancy on immune activity in Wistar rats" @default.
- W4313366220 doi "https://doi.org/10.4049/jimmunol.202.supp.191.18" @default.
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