SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366227> ?p ?o ?g. }

Showing items 1 to 74 of 74 with 100 items per page.

W4313366227 endingPage "190.10" @default.
W4313366227 startingPage "190.10" @default.
W4313366227 abstract "Abstract One fourth of the world population is infected with Mycobacterium tuberculosis (Mtb). Currently, BCG strains are the only vaccines available to protect against tuberculosis (TB). Our lab has identified γδ T cells that secrete Granzyme A (GzmA) with TB protective effects. GzmA when released by TB-specific γδ T cells has been shown to inhibit the intracellular replication of the pathogen. To elucidate the mechanism(s) involved in this inhibition, the lab has purified human GzmA. The effects of this highly purified GzmA on mycobacterial replication inside human macrophages are being investigated using systems biology. A 2D-DIGE proteomic approach of PBMC-adherent cells has been performed to identify putative pathways involved in the control of mycobacterial replication. Our preliminary analysis of two PPD+ volunteers indicates that ER-stress responses (HSPA5, HSP90B1, P4HB, PDIA3) and purinergic channel receptor activation (ATP5B/C1/D/H/O) may be important for GzmA-mediated intracellular mycobacterial inhibition. Verification of these results is being performed to confirm the overall mechanism, and to exclude unrelated signals. Elucidation of the detailed pathways involved in pathogen clearance could lead to the development of novel chemotherapeutic and/or immunotherapeutic approaches for control of Mtb infection." @default.
W4313366227 created "2023-01-06" @default.
W4313366227 creator A5005098179 @default.
W4313366227 creator A5029815230 @default.
W4313366227 creator A5062270833 @default.
W4313366227 creator A5065704094 @default.
W4313366227 creator A5074581391 @default.
W4313366227 date "2019-05-01" @default.
W4313366227 modified "2023-10-16" @default.
W4313366227 title "Mechanistic investigations of Granzyme A-mediated γ9δ2 T cell TB protective effects" @default.
W4313366227 doi "https://doi.org/10.4049/jimmunol.202.supp.190.10" @default.
W4313366227 hasPublicationYear "2019" @default.
W4313366227 type Work @default.
W4313366227 citedByCount "0" @default.
W4313366227 crossrefType "journal-article" @default.
W4313366227 hasAuthorship W4313366227A5005098179 @default.
W4313366227 hasAuthorship W4313366227A5029815230 @default.
W4313366227 hasAuthorship W4313366227A5062270833 @default.
W4313366227 hasAuthorship W4313366227A5065704094 @default.
W4313366227 hasAuthorship W4313366227A5074581391 @default.
W4313366227 hasConcept C142724271 @default.
W4313366227 hasConcept C167672396 @default.
W4313366227 hasConcept C183193105 @default.
W4313366227 hasConcept C203014093 @default.
W4313366227 hasConcept C2776062744 @default.
W4313366227 hasConcept C2776090121 @default.
W4313366227 hasConcept C2777975735 @default.
W4313366227 hasConcept C2780380082 @default.
W4313366227 hasConcept C2781069245 @default.
W4313366227 hasConcept C49039625 @default.
W4313366227 hasConcept C55493867 @default.
W4313366227 hasConcept C71924100 @default.
W4313366227 hasConcept C79879829 @default.
W4313366227 hasConcept C86803240 @default.
W4313366227 hasConcept C8891405 @default.
W4313366227 hasConcept C89423630 @default.
W4313366227 hasConcept C95444343 @default.
W4313366227 hasConceptScore W4313366227C142724271 @default.
W4313366227 hasConceptScore W4313366227C167672396 @default.
W4313366227 hasConceptScore W4313366227C183193105 @default.
W4313366227 hasConceptScore W4313366227C203014093 @default.
W4313366227 hasConceptScore W4313366227C2776062744 @default.
W4313366227 hasConceptScore W4313366227C2776090121 @default.
W4313366227 hasConceptScore W4313366227C2777975735 @default.
W4313366227 hasConceptScore W4313366227C2780380082 @default.
W4313366227 hasConceptScore W4313366227C2781069245 @default.
W4313366227 hasConceptScore W4313366227C49039625 @default.
W4313366227 hasConceptScore W4313366227C55493867 @default.
W4313366227 hasConceptScore W4313366227C71924100 @default.
W4313366227 hasConceptScore W4313366227C79879829 @default.
W4313366227 hasConceptScore W4313366227C86803240 @default.
W4313366227 hasConceptScore W4313366227C8891405 @default.
W4313366227 hasConceptScore W4313366227C89423630 @default.
W4313366227 hasConceptScore W4313366227C95444343 @default.
W4313366227 hasIssue "1_Supplement" @default.
W4313366227 hasLocation W43133662271 @default.
W4313366227 hasOpenAccess W4313366227 @default.
W4313366227 hasPrimaryLocation W43133662271 @default.
W4313366227 hasRelatedWork W1581093608 @default.
W4313366227 hasRelatedWork W1750541350 @default.
W4313366227 hasRelatedWork W2024878392 @default.
W4313366227 hasRelatedWork W2042814843 @default.
W4313366227 hasRelatedWork W2117222092 @default.
W4313366227 hasRelatedWork W2315617795 @default.
W4313366227 hasRelatedWork W2764223953 @default.
W4313366227 hasRelatedWork W2949594890 @default.
W4313366227 hasRelatedWork W3045576500 @default.
W4313366227 hasRelatedWork W3094064358 @default.
W4313366227 hasVolume "202" @default.
W4313366227 isParatext "false" @default.
W4313366227 isRetracted "false" @default.
W4313366227 workType "article" @default.