Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366236> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4313366236 endingPage "63.3" @default.
- W4313366236 startingPage "63.3" @default.
- W4313366236 abstract "Abstract Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) signaling adaptor that is essential for the type I interferon response to DNA pathogens. Aberrant activation of STING is linked to the pathology of autoimmune and autoinflammatory diseases. The rate-limiting step for the activation of STING is its translocation from the ER to the ER-Golgi intermediate compartment. Here, we found that deficiency in the Ca2+ sensor stromal interaction molecule 1 (STIM1) caused spontaneous activation of STING and enhanced expression of type I interferons under resting conditions in mice and a patient with combined immunodeficiency. Mechanistically, STIM1 associated with STING to retain it in the ER membrane, and coexpression of full-length STIM1 or a STING-interacting fragment of STIM1 suppressed the function of dominant STING mutants that cause autoinflammatory diseases. Furthermore, deficiency in STIM1 strongly enhanced the expression of type I interferons after viral infection and prevented the lethality of infection with a DNA virus in vivo. This work delineates a STIM1-STING circuit that maintains the resting state of the STING pathway." @default.
- W4313366236 created "2023-01-06" @default.
- W4313366236 creator A5004255490 @default.
- W4313366236 creator A5005679679 @default.
- W4313366236 creator A5010887421 @default.
- W4313366236 creator A5014254166 @default.
- W4313366236 creator A5022383655 @default.
- W4313366236 creator A5022586939 @default.
- W4313366236 creator A5027191469 @default.
- W4313366236 creator A5029398617 @default.
- W4313366236 creator A5029941597 @default.
- W4313366236 creator A5036075068 @default.
- W4313366236 creator A5044814548 @default.
- W4313366236 creator A5064666977 @default.
- W4313366236 creator A5067689954 @default.
- W4313366236 creator A5081093007 @default.
- W4313366236 creator A5082062550 @default.
- W4313366236 creator A5085291352 @default.
- W4313366236 creator A5090883669 @default.
- W4313366236 date "2019-05-01" @default.
- W4313366236 modified "2023-09-27" @default.
- W4313366236 title "The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum" @default.
- W4313366236 doi "https://doi.org/10.4049/jimmunol.202.supp.63.3" @default.
- W4313366236 hasPublicationYear "2019" @default.
- W4313366236 type Work @default.
- W4313366236 citedByCount "0" @default.
- W4313366236 crossrefType "journal-article" @default.
- W4313366236 hasAuthorship W4313366236A5004255490 @default.
- W4313366236 hasAuthorship W4313366236A5005679679 @default.
- W4313366236 hasAuthorship W4313366236A5010887421 @default.
- W4313366236 hasAuthorship W4313366236A5014254166 @default.
- W4313366236 hasAuthorship W4313366236A5022383655 @default.
- W4313366236 hasAuthorship W4313366236A5022586939 @default.
- W4313366236 hasAuthorship W4313366236A5027191469 @default.
- W4313366236 hasAuthorship W4313366236A5029398617 @default.
- W4313366236 hasAuthorship W4313366236A5029941597 @default.
- W4313366236 hasAuthorship W4313366236A5036075068 @default.
- W4313366236 hasAuthorship W4313366236A5044814548 @default.
- W4313366236 hasAuthorship W4313366236A5064666977 @default.
- W4313366236 hasAuthorship W4313366236A5067689954 @default.
- W4313366236 hasAuthorship W4313366236A5081093007 @default.
- W4313366236 hasAuthorship W4313366236A5082062550 @default.
- W4313366236 hasAuthorship W4313366236A5085291352 @default.
- W4313366236 hasAuthorship W4313366236A5090883669 @default.
- W4313366236 hasBestOaLocation W43133662362 @default.
- W4313366236 hasConcept C119062480 @default.
- W4313366236 hasConcept C127413603 @default.
- W4313366236 hasConcept C136449434 @default.
- W4313366236 hasConcept C146978453 @default.
- W4313366236 hasConcept C158617107 @default.
- W4313366236 hasConcept C162740809 @default.
- W4313366236 hasConcept C203014093 @default.
- W4313366236 hasConcept C2776178377 @default.
- W4313366236 hasConcept C2777349159 @default.
- W4313366236 hasConcept C2779300339 @default.
- W4313366236 hasConcept C62478195 @default.
- W4313366236 hasConcept C86803240 @default.
- W4313366236 hasConcept C8891405 @default.
- W4313366236 hasConcept C95444343 @default.
- W4313366236 hasConceptScore W4313366236C119062480 @default.
- W4313366236 hasConceptScore W4313366236C127413603 @default.
- W4313366236 hasConceptScore W4313366236C136449434 @default.
- W4313366236 hasConceptScore W4313366236C146978453 @default.
- W4313366236 hasConceptScore W4313366236C158617107 @default.
- W4313366236 hasConceptScore W4313366236C162740809 @default.
- W4313366236 hasConceptScore W4313366236C203014093 @default.
- W4313366236 hasConceptScore W4313366236C2776178377 @default.
- W4313366236 hasConceptScore W4313366236C2777349159 @default.
- W4313366236 hasConceptScore W4313366236C2779300339 @default.
- W4313366236 hasConceptScore W4313366236C62478195 @default.
- W4313366236 hasConceptScore W4313366236C86803240 @default.
- W4313366236 hasConceptScore W4313366236C8891405 @default.
- W4313366236 hasConceptScore W4313366236C95444343 @default.
- W4313366236 hasIssue "1_Supplement" @default.
- W4313366236 hasLocation W43133662361 @default.
- W4313366236 hasLocation W43133662362 @default.
- W4313366236 hasLocation W43133662363 @default.
- W4313366236 hasLocation W43133662364 @default.
- W4313366236 hasOpenAccess W4313366236 @default.
- W4313366236 hasPrimaryLocation W43133662361 @default.
- W4313366236 hasRelatedWork W2009793475 @default.
- W4313366236 hasRelatedWork W2045641731 @default.
- W4313366236 hasRelatedWork W2060725758 @default.
- W4313366236 hasRelatedWork W2062039007 @default.
- W4313366236 hasRelatedWork W2150351373 @default.
- W4313366236 hasRelatedWork W4241790563 @default.
- W4313366236 hasRelatedWork W4243116727 @default.
- W4313366236 hasRelatedWork W4286110560 @default.
- W4313366236 hasRelatedWork W4312084899 @default.
- W4313366236 hasRelatedWork W4313366236 @default.
- W4313366236 hasVolume "202" @default.
- W4313366236 isParatext "false" @default.
- W4313366236 isRetracted "false" @default.
- W4313366236 workType "article" @default.