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- W4313366239 abstract "Abstract Vaccines and monoclonal antibodies (mAb) have been proposed as a therapeutic option for substance use disorders by selectively sequestering the target drug in serum and preventing drug distribution to the brain and drug-induced toxicity. Although there are multiple pharmacological interventions available to treat opioid use disorder, issues such as access, side effects, and compliance limit their clinical use. As an advantage over opioid receptor antagonists, opioid-specific antibodies do not interfere with endogenous opioid signaling. Whereas clinical efficacy of vaccines for substance use disorder is limited, as up to 70% of subjects do not achieve antibody levels sufficient for efficacy, passive immunization with opioid-specific mAb circumvents this limitation. We have developed a method to rapidly generate hybridomas expressing opioid-specific mAb by magnetic enrichment of opioid-specific B cells prior to fusion. Using this strategy, we identified murine hybridomas expressing mAb specific for oxycodone, morphine and fentanyl. Passive immunization with purified opioid-specific mAb was effective in reducing opioid distribution to the brain in mice. In this study, mAb consisting of different IgG subclasses were compared for efficacy against oxycodone. Sequencing of opioid-specific mAb showed limited variability in antigen-binding regions. Integration of functional, structural and sequencing characterization can aid development of next-generation mAbs for treatment of opioid use disorder, or to counteract other toxic chemicals." @default.
- W4313366239 created "2023-01-06" @default.
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- W4313366239 date "2019-05-01" @default.
- W4313366239 modified "2023-09-26" @default.
- W4313366239 title "Monoclonal antibodies for reducing opioid use disorders and overdose" @default.
- W4313366239 doi "https://doi.org/10.4049/jimmunol.202.supp.70.18" @default.
- W4313366239 hasPublicationYear "2019" @default.
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