Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366248> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4313366248 endingPage "57.10" @default.
- W4313366248 startingPage "57.10" @default.
- W4313366248 abstract "Abstract Immune tolerance mediated by regulatory T cells is important in the control of homeostasis. The characterization of regulatory CD8 T cells has been hampered by inability to distinguish them from conventional CD8 T cells. We have identified a novel population of unconventional cytotoxic TCRαβ+CD8+ T cells with regulatory properties, called uTr, in both naïve mice and humans. The uTr cells are innate-like, express the promyelocytic leukemia zinc finger (PLZF) transcription factor and display an activated-memory phenotype (CD122high, CD44high,CD62Llow, CD69+). They are CD8αα+, NK1.1+(CD161+ in human), express NK inhibitory receptors and are dependent upon IL-15/IL-2Rβ signaling. A significant decrease in the frequency of uTr cells in PLZF−/− mice suggests their dependency on PLZF expression. Similarly, a significant reduction of uTr cells in Qa-1b−/− mice indicates that a sizable proportion of them are restricted by Qa-1b MHC molecules. The deep-sequencing, RT-PCR and FACS analysis of sorted hepatic uTr cells indicate a polyclonal TCR repertoire in both mice and humans. Adoptive transfer of sorted hepatic uTr cells but not conventional CD8 T cells protects B6 mice from EAE as well as RAG1−/− mice from T cell-induced colitis. The uTr cells secrete IFNγ, IL-4 and IL-17 but not TGFβ and express perforin and granzyme B and the mechanism(s) of regulation is dependent upon perforin. The uTr cells are distinct from other unconventional T cells, including NKT cells, NKT-dependent innate-like CD8 T and MAIT cells. Collectively, we have identified a novel unconventional regulatory CD8 T cells that are involved in a negative feedback mechanism of regulation of autoimmunity and also have important implications for anti-cancer immunity." @default.
- W4313366248 created "2023-01-06" @default.
- W4313366248 creator A5010042495 @default.
- W4313366248 creator A5011235188 @default.
- W4313366248 creator A5012642611 @default.
- W4313366248 creator A5019987457 @default.
- W4313366248 creator A5032264417 @default.
- W4313366248 creator A5072512711 @default.
- W4313366248 creator A5091696726 @default.
- W4313366248 date "2019-05-01" @default.
- W4313366248 modified "2023-10-10" @default.
- W4313366248 title "Negative feedback control of autoimmunity by a novel population of regulatory unconventional CD8+ T cells" @default.
- W4313366248 doi "https://doi.org/10.4049/jimmunol.202.supp.57.10" @default.
- W4313366248 hasPublicationYear "2019" @default.
- W4313366248 type Work @default.
- W4313366248 citedByCount "0" @default.
- W4313366248 crossrefType "journal-article" @default.
- W4313366248 hasAuthorship W4313366248A5010042495 @default.
- W4313366248 hasAuthorship W4313366248A5011235188 @default.
- W4313366248 hasAuthorship W4313366248A5012642611 @default.
- W4313366248 hasAuthorship W4313366248A5019987457 @default.
- W4313366248 hasAuthorship W4313366248A5032264417 @default.
- W4313366248 hasAuthorship W4313366248A5072512711 @default.
- W4313366248 hasAuthorship W4313366248A5091696726 @default.
- W4313366248 hasConcept C120642132 @default.
- W4313366248 hasConcept C129374314 @default.
- W4313366248 hasConcept C139563560 @default.
- W4313366248 hasConcept C144024400 @default.
- W4313366248 hasConcept C149923435 @default.
- W4313366248 hasConcept C154317977 @default.
- W4313366248 hasConcept C167672396 @default.
- W4313366248 hasConcept C202751555 @default.
- W4313366248 hasConcept C203014093 @default.
- W4313366248 hasConcept C2776090121 @default.
- W4313366248 hasConcept C2780380082 @default.
- W4313366248 hasConcept C2908647359 @default.
- W4313366248 hasConcept C54355233 @default.
- W4313366248 hasConcept C79484868 @default.
- W4313366248 hasConcept C86803240 @default.
- W4313366248 hasConcept C8891405 @default.
- W4313366248 hasConcept C90375314 @default.
- W4313366248 hasConcept C95444343 @default.
- W4313366248 hasConceptScore W4313366248C120642132 @default.
- W4313366248 hasConceptScore W4313366248C129374314 @default.
- W4313366248 hasConceptScore W4313366248C139563560 @default.
- W4313366248 hasConceptScore W4313366248C144024400 @default.
- W4313366248 hasConceptScore W4313366248C149923435 @default.
- W4313366248 hasConceptScore W4313366248C154317977 @default.
- W4313366248 hasConceptScore W4313366248C167672396 @default.
- W4313366248 hasConceptScore W4313366248C202751555 @default.
- W4313366248 hasConceptScore W4313366248C203014093 @default.
- W4313366248 hasConceptScore W4313366248C2776090121 @default.
- W4313366248 hasConceptScore W4313366248C2780380082 @default.
- W4313366248 hasConceptScore W4313366248C2908647359 @default.
- W4313366248 hasConceptScore W4313366248C54355233 @default.
- W4313366248 hasConceptScore W4313366248C79484868 @default.
- W4313366248 hasConceptScore W4313366248C86803240 @default.
- W4313366248 hasConceptScore W4313366248C8891405 @default.
- W4313366248 hasConceptScore W4313366248C90375314 @default.
- W4313366248 hasConceptScore W4313366248C95444343 @default.
- W4313366248 hasIssue "1_Supplement" @default.
- W4313366248 hasLocation W43133662481 @default.
- W4313366248 hasOpenAccess W4313366248 @default.
- W4313366248 hasPrimaryLocation W43133662481 @default.
- W4313366248 hasRelatedWork W1488327521 @default.
- W4313366248 hasRelatedWork W1606264375 @default.
- W4313366248 hasRelatedWork W2030345324 @default.
- W4313366248 hasRelatedWork W2035583085 @default.
- W4313366248 hasRelatedWork W2052493267 @default.
- W4313366248 hasRelatedWork W2115956819 @default.
- W4313366248 hasRelatedWork W2123317146 @default.
- W4313366248 hasRelatedWork W2159389701 @default.
- W4313366248 hasRelatedWork W2366412323 @default.
- W4313366248 hasRelatedWork W4313374697 @default.
- W4313366248 hasVolume "202" @default.
- W4313366248 isParatext "false" @default.
- W4313366248 isRetracted "false" @default.
- W4313366248 workType "article" @default.