Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366257> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313366257 endingPage "189.4" @default.
- W4313366257 startingPage "189.4" @default.
- W4313366257 abstract "Abstract Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, South Korea In a steady-state, naïve CD8+ T cells are kept to be quiescent in response to homeostatic cues such as self-ligands and cytokines while preserving a robust responsiveness to foreign antigens. Although such a steady-state quiescence involves multiple regulators, an exact nature of the regulators and underlying mechanisms are still incompletely understood. Here we showed that the signal transducer and activator of transcription 1 (STAT1), a key transcription factor downstream of type I and II interferon receptor signaling, plays a cell-intrinsic role in regulating naïve CD8+ T cell responsiveness to tonic homeostatic cytokines. Thus, mice lacking STAT1 led to abnormalities in the composition and number of naïve and effector/memory phenotype among CD8+ T cells. The observed alterations were not due to dysregulation in thymic development but rather resulted from enhanced proliferative capacity of peripheral mature STAT1-deficient naïve CD8+ T cells in a cell-autonomous manner. In vitro analyses revealed that two key cytokines, IL-7 and type I interferon, serve as a major driver to induce abnormal proliferation of STAT1-deficient but not wild-type CD8+ T cells depending on a pathway that is sensitive to rapamycin, indicating a role of mTORC1 signaling. Based on these findings, we suggest that, under steady-state, naïve CD8+ T cells that are continuously exposed to homeostatic cytokines actively restrain their responsiveness to the “Goldilocks” levels – that is, not too strong to induce activation/proliferation and not too weak to lose a survival ability – presumably via blocking mTORC1 pathway, therefore maintaining a functional state of quiescence before encountering a cognate foreign antigen." @default.
- W4313366257 created "2023-01-06" @default.
- W4313366257 creator A5053655964 @default.
- W4313366257 creator A5063144445 @default.
- W4313366257 creator A5085733014 @default.
- W4313366257 date "2019-05-01" @default.
- W4313366257 modified "2023-09-26" @default.
- W4313366257 title "STAT1 restrains peripheral naive CD8+ T cell responsiveness to homeostatic cytokines by regulating mTORC1 signaling" @default.
- W4313366257 doi "https://doi.org/10.4049/jimmunol.202.supp.189.4" @default.
- W4313366257 hasPublicationYear "2019" @default.
- W4313366257 type Work @default.
- W4313366257 citedByCount "0" @default.
- W4313366257 crossrefType "journal-article" @default.
- W4313366257 hasAuthorship W4313366257A5053655964 @default.
- W4313366257 hasAuthorship W4313366257A5063144445 @default.
- W4313366257 hasAuthorship W4313366257A5085733014 @default.
- W4313366257 hasConcept C104317684 @default.
- W4313366257 hasConcept C154317977 @default.
- W4313366257 hasConcept C167672396 @default.
- W4313366257 hasConcept C171958077 @default.
- W4313366257 hasConcept C202751555 @default.
- W4313366257 hasConcept C203014093 @default.
- W4313366257 hasConcept C2776090121 @default.
- W4313366257 hasConcept C2777003663 @default.
- W4313366257 hasConcept C2778923194 @default.
- W4313366257 hasConcept C54355233 @default.
- W4313366257 hasConcept C62478195 @default.
- W4313366257 hasConcept C63645605 @default.
- W4313366257 hasConcept C79484868 @default.
- W4313366257 hasConcept C86339819 @default.
- W4313366257 hasConcept C86554907 @default.
- W4313366257 hasConcept C86803240 @default.
- W4313366257 hasConcept C8891405 @default.
- W4313366257 hasConcept C95444343 @default.
- W4313366257 hasConcept C98490376 @default.
- W4313366257 hasConceptScore W4313366257C104317684 @default.
- W4313366257 hasConceptScore W4313366257C154317977 @default.
- W4313366257 hasConceptScore W4313366257C167672396 @default.
- W4313366257 hasConceptScore W4313366257C171958077 @default.
- W4313366257 hasConceptScore W4313366257C202751555 @default.
- W4313366257 hasConceptScore W4313366257C203014093 @default.
- W4313366257 hasConceptScore W4313366257C2776090121 @default.
- W4313366257 hasConceptScore W4313366257C2777003663 @default.
- W4313366257 hasConceptScore W4313366257C2778923194 @default.
- W4313366257 hasConceptScore W4313366257C54355233 @default.
- W4313366257 hasConceptScore W4313366257C62478195 @default.
- W4313366257 hasConceptScore W4313366257C63645605 @default.
- W4313366257 hasConceptScore W4313366257C79484868 @default.
- W4313366257 hasConceptScore W4313366257C86339819 @default.
- W4313366257 hasConceptScore W4313366257C86554907 @default.
- W4313366257 hasConceptScore W4313366257C86803240 @default.
- W4313366257 hasConceptScore W4313366257C8891405 @default.
- W4313366257 hasConceptScore W4313366257C95444343 @default.
- W4313366257 hasConceptScore W4313366257C98490376 @default.
- W4313366257 hasIssue "1_Supplement" @default.
- W4313366257 hasLocation W43133662571 @default.
- W4313366257 hasOpenAccess W4313366257 @default.
- W4313366257 hasPrimaryLocation W43133662571 @default.
- W4313366257 hasRelatedWork W1582632911 @default.
- W4313366257 hasRelatedWork W2063492259 @default.
- W4313366257 hasRelatedWork W2159389701 @default.
- W4313366257 hasRelatedWork W2340030127 @default.
- W4313366257 hasRelatedWork W2417160039 @default.
- W4313366257 hasRelatedWork W2502297276 @default.
- W4313366257 hasRelatedWork W4313354824 @default.
- W4313366257 hasRelatedWork W4313358968 @default.
- W4313366257 hasRelatedWork W4313366257 @default.
- W4313366257 hasRelatedWork W4317608975 @default.
- W4313366257 hasVolume "202" @default.
- W4313366257 isParatext "false" @default.
- W4313366257 isRetracted "false" @default.
- W4313366257 workType "article" @default.