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- W4313366268 abstract "Abstract The elderly are more susceptible to pulmonary infections including tuberculosis. Here, we examined the impact of aging on the phenotype and response of mouse alveolar macrophages (AMs) to Mycobacterium tuberculosis (M.tb). AMs were isolated from bronchoalveolar lavage fluid (BALF) of young (3 month) and old (18 month) C57BL/6 mice. AMs from old mice expressed higher mRNA levels of CCL2, IFN-β, IL-10, IL-12p40, TNFα and MIF than young mice and old mice contained higher levels of CCL2, IFN-β, IL-1β and MIF in their BALF. Flow cytometry analysis of AMs showed two distinct AM populations, a major CD11c+ CD11b− and a minor CD11c+CD11b+ population, the latter was significantly increased in old mice. Expression of CD206, TLR2, CD16/CD32, MHC class II and CD86 was higher in the CD11c+CD11b+ AMs and these AMs expressed monocytic markers Ly6C, C3CR1, and CD115, suggesting they are of monocytic origin. Sorted CD11c+CD11b+ AMs expressed higher mRNA levels of CCL2, IL-1β, and IL-6, whereas CD11c+ CD11b− AMs expressed higher mRNA levels of immune-regulatory cytokines IFN-β and IL-10. CD11c+CD11b+ AMs phagocytosed more M.tb, and M.tb in these AMs expressed higher RNA levels of genes required its survival. Our studies identify two distinct AM populations in old mice, specifically a novel CD11c+CD11b+ AM population which is hyper-inflammatory and phagocytoses M.tb more efficiently, yet is more permissive for M.tb survival than the CD11c+CD11b− population which is more immuno-regulatory in nature. Our results also indicate that the lung cytokine environment of old mice contains an unusual array of both pro-inflammatory and immune-regulatory cytokines." @default.
- W4313366268 created "2023-01-06" @default.
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- W4313366268 date "2019-05-01" @default.
- W4313366268 modified "2023-09-26" @default.
- W4313366268 title "Phenotypic analysis of alveolar macrophage populations in old mice and their response to <i>Mycobacterium tuberculosis</i> infection" @default.
- W4313366268 doi "https://doi.org/10.4049/jimmunol.202.supp.62.3" @default.
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