Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366326> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313366326 endingPage "49.4" @default.
- W4313366326 startingPage "49.4" @default.
- W4313366326 abstract "Abstract Macrophages mediate innate immune responses via a spectrum of phenotypes that range from inflammatory to resolving. We previously identified CD38 as a robust marker of inflammatory macrophages useful in both murine in vitro and in vivo models. We hypothesized that CD38 plays a similar biomarker and/or functional role in human macrophages and autoimmune inflammatory disease. Using human macrophages of primary or monocytic cell line origin, we found that CD38 is robustly induced in human macrophages exposed to LPS and IFN-g inflammatory stimuli, but not with the alternative stimulus, IL-4. Analyses in the systemic autoimmune disease Systemic Lupus Erythematosus (SLE) revealed that CD38hi classical and non-classical monocyte subpopulations are associated with disease activity. In addition, genetic or pharmacologic CD38 loss-of-function in human primary macrophages resulted in suppressed inflammatory cytokines IL-6 and IL-12p40 secretion in human primary macrophages. Taken together, these findings support a biomarker and functional role for CD38 in inflammatory macrophages/monocytes and inflammatory disease." @default.
- W4313366326 created "2023-01-06" @default.
- W4313366326 creator A5003908559 @default.
- W4313366326 creator A5026103947 @default.
- W4313366326 creator A5027549998 @default.
- W4313366326 creator A5071211166 @default.
- W4313366326 creator A5077734007 @default.
- W4313366326 creator A5090099694 @default.
- W4313366326 date "2018-05-01" @default.
- W4313366326 modified "2023-10-01" @default.
- W4313366326 title "CD38: biomarker and functional role in human macrophages" @default.
- W4313366326 doi "https://doi.org/10.4049/jimmunol.200.supp.49.4" @default.
- W4313366326 hasPublicationYear "2018" @default.
- W4313366326 type Work @default.
- W4313366326 citedByCount "0" @default.
- W4313366326 crossrefType "journal-article" @default.
- W4313366326 hasAuthorship W4313366326A5003908559 @default.
- W4313366326 hasAuthorship W4313366326A5026103947 @default.
- W4313366326 hasAuthorship W4313366326A5027549998 @default.
- W4313366326 hasAuthorship W4313366326A5071211166 @default.
- W4313366326 hasAuthorship W4313366326A5077734007 @default.
- W4313366326 hasAuthorship W4313366326A5090099694 @default.
- W4313366326 hasConcept C10205521 @default.
- W4313366326 hasConcept C136449434 @default.
- W4313366326 hasConcept C150903083 @default.
- W4313366326 hasConcept C159912055 @default.
- W4313366326 hasConcept C202751555 @default.
- W4313366326 hasConcept C203014093 @default.
- W4313366326 hasConcept C207001950 @default.
- W4313366326 hasConcept C2776914184 @default.
- W4313366326 hasConcept C2779244956 @default.
- W4313366326 hasConcept C2781184567 @default.
- W4313366326 hasConcept C2781197716 @default.
- W4313366326 hasConcept C28328180 @default.
- W4313366326 hasConcept C55493867 @default.
- W4313366326 hasConcept C71924100 @default.
- W4313366326 hasConcept C86803240 @default.
- W4313366326 hasConcept C8891405 @default.
- W4313366326 hasConcept C95444343 @default.
- W4313366326 hasConceptScore W4313366326C10205521 @default.
- W4313366326 hasConceptScore W4313366326C136449434 @default.
- W4313366326 hasConceptScore W4313366326C150903083 @default.
- W4313366326 hasConceptScore W4313366326C159912055 @default.
- W4313366326 hasConceptScore W4313366326C202751555 @default.
- W4313366326 hasConceptScore W4313366326C203014093 @default.
- W4313366326 hasConceptScore W4313366326C207001950 @default.
- W4313366326 hasConceptScore W4313366326C2776914184 @default.
- W4313366326 hasConceptScore W4313366326C2779244956 @default.
- W4313366326 hasConceptScore W4313366326C2781184567 @default.
- W4313366326 hasConceptScore W4313366326C2781197716 @default.
- W4313366326 hasConceptScore W4313366326C28328180 @default.
- W4313366326 hasConceptScore W4313366326C55493867 @default.
- W4313366326 hasConceptScore W4313366326C71924100 @default.
- W4313366326 hasConceptScore W4313366326C86803240 @default.
- W4313366326 hasConceptScore W4313366326C8891405 @default.
- W4313366326 hasConceptScore W4313366326C95444343 @default.
- W4313366326 hasIssue "1_Supplement" @default.
- W4313366326 hasLocation W43133663261 @default.
- W4313366326 hasOpenAccess W4313366326 @default.
- W4313366326 hasPrimaryLocation W43133663261 @default.
- W4313366326 hasRelatedWork W1556307916 @default.
- W4313366326 hasRelatedWork W1557621914 @default.
- W4313366326 hasRelatedWork W1981947243 @default.
- W4313366326 hasRelatedWork W2103515427 @default.
- W4313366326 hasRelatedWork W2141330728 @default.
- W4313366326 hasRelatedWork W2477962055 @default.
- W4313366326 hasRelatedWork W2531302392 @default.
- W4313366326 hasRelatedWork W2884874570 @default.
- W4313366326 hasRelatedWork W3136031961 @default.
- W4313366326 hasRelatedWork W4315797293 @default.
- W4313366326 hasVolume "200" @default.
- W4313366326 isParatext "false" @default.
- W4313366326 isRetracted "false" @default.
- W4313366326 workType "article" @default.