Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366327> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4313366327 endingPage "49.9" @default.
- W4313366327 startingPage "49.9" @default.
- W4313366327 abstract "Abstract Killer cell lectin-like receptor G1 (KLRG1) is a C-type lectin inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. KLRG1 is well conserved in mammals and is mostly expressed on subsets of T cells and natural killer (NK) cells. Upon binding to its ligands, N-cadherin and E-cadherin, the phosphatases SHP-2 and SHIP-1 are recruited to the cytoplasmic tail of KLRG1. Some studies have proposed that KLRG1 is a marker of senescence, while other studies suggest that KLRG1 is a marker of recently activated cells. In addition, although KLRG1 inhibitory potential has been established in vitro, it is unclear whether KLRG1 inhibits NK cells and CD8+ T cells in vivo. To address its exact role, we have used CRISPR technology to generate mice deficient for KLRG1 and mice conditionally deficient for KLRG1 in the NK cell lineage. We found that NK cell frequency and number is not effected and that NK cell development is globally intact in KLRG1 deficient mice. The role of KLRG1 during viral infections and tumor development is currently being investigated." @default.
- W4313366327 created "2023-01-06" @default.
- W4313366327 creator A5060740399 @default.
- W4313366327 creator A5071161157 @default.
- W4313366327 date "2018-05-01" @default.
- W4313366327 modified "2023-10-14" @default.
- W4313366327 title "Role of the KLRG1 pathway in the immune response" @default.
- W4313366327 doi "https://doi.org/10.4049/jimmunol.200.supp.49.9" @default.
- W4313366327 hasPublicationYear "2018" @default.
- W4313366327 type Work @default.
- W4313366327 citedByCount "3" @default.
- W4313366327 countsByYear W43133663272022 @default.
- W4313366327 countsByYear W43133663272023 @default.
- W4313366327 crossrefType "journal-article" @default.
- W4313366327 hasAuthorship W4313366327A5060740399 @default.
- W4313366327 hasAuthorship W4313366327A5071161157 @default.
- W4313366327 hasConcept C129374314 @default.
- W4313366327 hasConcept C139563560 @default.
- W4313366327 hasConcept C149532602 @default.
- W4313366327 hasConcept C154317977 @default.
- W4313366327 hasConcept C167672396 @default.
- W4313366327 hasConcept C202751555 @default.
- W4313366327 hasConcept C203014093 @default.
- W4313366327 hasConcept C28651165 @default.
- W4313366327 hasConcept C55493867 @default.
- W4313366327 hasConcept C86803240 @default.
- W4313366327 hasConcept C8891405 @default.
- W4313366327 hasConcept C95444343 @default.
- W4313366327 hasConceptScore W4313366327C129374314 @default.
- W4313366327 hasConceptScore W4313366327C139563560 @default.
- W4313366327 hasConceptScore W4313366327C149532602 @default.
- W4313366327 hasConceptScore W4313366327C154317977 @default.
- W4313366327 hasConceptScore W4313366327C167672396 @default.
- W4313366327 hasConceptScore W4313366327C202751555 @default.
- W4313366327 hasConceptScore W4313366327C203014093 @default.
- W4313366327 hasConceptScore W4313366327C28651165 @default.
- W4313366327 hasConceptScore W4313366327C55493867 @default.
- W4313366327 hasConceptScore W4313366327C86803240 @default.
- W4313366327 hasConceptScore W4313366327C8891405 @default.
- W4313366327 hasConceptScore W4313366327C95444343 @default.
- W4313366327 hasIssue "1_Supplement" @default.
- W4313366327 hasLocation W43133663271 @default.
- W4313366327 hasOpenAccess W4313366327 @default.
- W4313366327 hasPrimaryLocation W43133663271 @default.
- W4313366327 hasRelatedWork W1830230921 @default.
- W4313366327 hasRelatedWork W1973887889 @default.
- W4313366327 hasRelatedWork W199336330 @default.
- W4313366327 hasRelatedWork W2020960833 @default.
- W4313366327 hasRelatedWork W2049687639 @default.
- W4313366327 hasRelatedWork W2074969559 @default.
- W4313366327 hasRelatedWork W2139250003 @default.
- W4313366327 hasRelatedWork W2475299811 @default.
- W4313366327 hasRelatedWork W394065362 @default.
- W4313366327 hasRelatedWork W820885979 @default.
- W4313366327 hasVolume "200" @default.
- W4313366327 isParatext "false" @default.
- W4313366327 isRetracted "false" @default.
- W4313366327 workType "article" @default.