Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366338> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313366338 endingPage "190.84" @default.
- W4313366338 startingPage "190.84" @default.
- W4313366338 abstract "Abstract Recurrence of C. difficile infection with progressively worsening disease is a serious problem. Serum IgG specific to the secreted toxin B (TcdB) is the best-known correlate of protection against disease symptoms and pathology. However, little is known as to whether and how infection stimulates protective humoral immunity. We hypothesized that recurring disease is due to an inadequate development of a TcdB-specific memory B cell response following an initial infection. We measured TcdB-specific antibody and memory B-cell responses following two sequential infections in microbiome-disrupted B6 mice. A mild infection caused by a low dose spore challenge did not induce an isotype-switched antibody response against the toxin and failed to protect against recurring disease. However, a higher-dose infection resulted in a TcdB-specific primary serum IgG1 and IgG2b response but did not boost titers. Also, in mice with TcdB-specific serum IgG1 there was a strong correlation with fecal TcdB-specific IgG1 and an attenuation of subsequent disease. Following infection of TcdB-immunized mice, IgG1 titers did not increase and ELISPOT analyses detected TcdB-specific IgG1-secreting plasma cells primarily in the bone marrow. Infection of pre-immunized mice also resulted in increased amounts of TcdB-specific IgG1 reaching the gut lumen. These findings indicate that a more severe initial encounter with the pathogen may be required to elicit a protective systemic TcdB-specific IgG1 response. Re-infection or infection of pre-immunized mice does not stimulate a B cell memory response and protection appears to be mediated by transport of plasma cell-derived systemic IgG1 to the gut lumen." @default.
- W4313366338 created "2023-01-06" @default.
- W4313366338 creator A5021315525 @default.
- W4313366338 creator A5034631123 @default.
- W4313366338 creator A5054934145 @default.
- W4313366338 creator A5068433301 @default.
- W4313366338 date "2019-05-01" @default.
- W4313366338 modified "2023-09-26" @default.
- W4313366338 title "TcdB-specific plasma cell and memory B cell responses in recurring <i>Clostridioides difficile</i> infection-associated disease" @default.
- W4313366338 doi "https://doi.org/10.4049/jimmunol.202.supp.190.84" @default.
- W4313366338 hasPublicationYear "2019" @default.
- W4313366338 type Work @default.
- W4313366338 citedByCount "0" @default.
- W4313366338 crossrefType "journal-article" @default.
- W4313366338 hasAuthorship W4313366338A5021315525 @default.
- W4313366338 hasAuthorship W4313366338A5034631123 @default.
- W4313366338 hasAuthorship W4313366338A5054934145 @default.
- W4313366338 hasAuthorship W4313366338A5068433301 @default.
- W4313366338 hasConcept C126322002 @default.
- W4313366338 hasConcept C159047783 @default.
- W4313366338 hasConcept C159654299 @default.
- W4313366338 hasConcept C203014093 @default.
- W4313366338 hasConcept C2776090121 @default.
- W4313366338 hasConcept C2778453870 @default.
- W4313366338 hasConcept C2779053233 @default.
- W4313366338 hasConcept C2779134260 @default.
- W4313366338 hasConcept C2779341262 @default.
- W4313366338 hasConcept C2779359726 @default.
- W4313366338 hasConcept C2780898057 @default.
- W4313366338 hasConcept C71924100 @default.
- W4313366338 hasConcept C86803240 @default.
- W4313366338 hasConcept C8891405 @default.
- W4313366338 hasConceptScore W4313366338C126322002 @default.
- W4313366338 hasConceptScore W4313366338C159047783 @default.
- W4313366338 hasConceptScore W4313366338C159654299 @default.
- W4313366338 hasConceptScore W4313366338C203014093 @default.
- W4313366338 hasConceptScore W4313366338C2776090121 @default.
- W4313366338 hasConceptScore W4313366338C2778453870 @default.
- W4313366338 hasConceptScore W4313366338C2779053233 @default.
- W4313366338 hasConceptScore W4313366338C2779134260 @default.
- W4313366338 hasConceptScore W4313366338C2779341262 @default.
- W4313366338 hasConceptScore W4313366338C2779359726 @default.
- W4313366338 hasConceptScore W4313366338C2780898057 @default.
- W4313366338 hasConceptScore W4313366338C71924100 @default.
- W4313366338 hasConceptScore W4313366338C86803240 @default.
- W4313366338 hasConceptScore W4313366338C8891405 @default.
- W4313366338 hasIssue "1_Supplement" @default.
- W4313366338 hasLocation W43133663381 @default.
- W4313366338 hasOpenAccess W4313366338 @default.
- W4313366338 hasPrimaryLocation W43133663381 @default.
- W4313366338 hasRelatedWork W1564495924 @default.
- W4313366338 hasRelatedWork W1999950451 @default.
- W4313366338 hasRelatedWork W2293144235 @default.
- W4313366338 hasRelatedWork W2399536512 @default.
- W4313366338 hasRelatedWork W2599339510 @default.
- W4313366338 hasRelatedWork W3100663742 @default.
- W4313366338 hasRelatedWork W3160803401 @default.
- W4313366338 hasRelatedWork W3184498267 @default.
- W4313366338 hasRelatedWork W3212838014 @default.
- W4313366338 hasRelatedWork W4210752790 @default.
- W4313366338 hasVolume "202" @default.
- W4313366338 isParatext "false" @default.
- W4313366338 isRetracted "false" @default.
- W4313366338 workType "article" @default.