Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366343> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4313366343 endingPage "136.10" @default.
- W4313366343 startingPage "136.10" @default.
- W4313366343 abstract "Abstract A better understanding of the role of Immune checkpoint inhibitors (ICI) and immunoregulatory genes HLA-G is essential for the development of immunotherapeutic strategies in cancer. This study aims to evaluate the influence of CTLA-4, PD-1 and polymorphisms of HLA-G and soluble HLA-G (sHLA-G) in patients with cervical cancer (CC), different degrees of Cervical Intraepithelial Neoplasia (CIN), and healthy control (HC). One hundred and seventy-four (174) non-pregnant Brazilian women, sexually active, older than 18 years, were evaluated. These patients were stratified according to the results of the anatomopathological examination in: CC group n=24, Low-grade squamous intraepithelial lesions (LSIL) n=66, High-grade squamous intraepithelial lesions (HSIL) n=84. HC group consisted of 47 women without cytological and/or colposcopic abnormalities detected. The peripheral blood of these patients was collected for analysis of CTLA-4, PD-1 and HLA-G polymorphisms using real-time PCR. The analysis indicated a significantly higher 14bpDel allele frequency in CC when compared to HC group (P=0.030, OR=1.71, 95%CI 1.01–2.74). Moreover, the 14bpDel/Del genotype frequency was also significantly higher in patients with CC group (P = 0.035, OR=2.23, 95%CI 1.05–4.97). Qualitative analysis revealed that the production of sHLA-G is detectable in 52.03% (n=77) of all patients groups and 34.29 %(n=12) in HC groups. This analysis revealed a trend of significance (P= 0.063; OR=2.08, 95%CI=0.96–4.48) in CC group. The polymorphisms of CTLA-4 and 14 bp HLA-G are associated with a significantly increased risk of CC. HLA-G 14bp Del/Del polymorphism, and the serum sHLA-G can act as a promising biomarker for might be a genetic risk factor for CC." @default.
- W4313366343 created "2023-01-06" @default.
- W4313366343 creator A5003055306 @default.
- W4313366343 creator A5011649801 @default.
- W4313366343 creator A5018024497 @default.
- W4313366343 creator A5021745021 @default.
- W4313366343 creator A5022973403 @default.
- W4313366343 creator A5025554091 @default.
- W4313366343 creator A5037343598 @default.
- W4313366343 creator A5043354362 @default.
- W4313366343 creator A5057699355 @default.
- W4313366343 creator A5061587246 @default.
- W4313366343 creator A5072598791 @default.
- W4313366343 date "2019-05-01" @default.
- W4313366343 modified "2023-09-26" @default.
- W4313366343 title "Influence of immune-checkpoint inhibitor and <i>HLA-G</i> in patients with Cervical Cancer" @default.
- W4313366343 doi "https://doi.org/10.4049/jimmunol.202.supp.136.10" @default.
- W4313366343 hasPublicationYear "2019" @default.
- W4313366343 type Work @default.
- W4313366343 citedByCount "0" @default.
- W4313366343 crossrefType "journal-article" @default.
- W4313366343 hasAuthorship W4313366343A5003055306 @default.
- W4313366343 hasAuthorship W4313366343A5011649801 @default.
- W4313366343 hasAuthorship W4313366343A5018024497 @default.
- W4313366343 hasAuthorship W4313366343A5021745021 @default.
- W4313366343 hasAuthorship W4313366343A5022973403 @default.
- W4313366343 hasAuthorship W4313366343A5025554091 @default.
- W4313366343 hasAuthorship W4313366343A5037343598 @default.
- W4313366343 hasAuthorship W4313366343A5043354362 @default.
- W4313366343 hasAuthorship W4313366343A5057699355 @default.
- W4313366343 hasAuthorship W4313366343A5061587246 @default.
- W4313366343 hasAuthorship W4313366343A5072598791 @default.
- W4313366343 hasConcept C104317684 @default.
- W4313366343 hasConcept C121608353 @default.
- W4313366343 hasConcept C126322002 @default.
- W4313366343 hasConcept C135763542 @default.
- W4313366343 hasConcept C143998085 @default.
- W4313366343 hasConcept C147483822 @default.
- W4313366343 hasConcept C188280979 @default.
- W4313366343 hasConcept C203014093 @default.
- W4313366343 hasConcept C2777343196 @default.
- W4313366343 hasConcept C2778220009 @default.
- W4313366343 hasConcept C55493867 @default.
- W4313366343 hasConcept C71924100 @default.
- W4313366343 hasConcept C86803240 @default.
- W4313366343 hasConcept C8891405 @default.
- W4313366343 hasConcept C90924648 @default.
- W4313366343 hasConceptScore W4313366343C104317684 @default.
- W4313366343 hasConceptScore W4313366343C121608353 @default.
- W4313366343 hasConceptScore W4313366343C126322002 @default.
- W4313366343 hasConceptScore W4313366343C135763542 @default.
- W4313366343 hasConceptScore W4313366343C143998085 @default.
- W4313366343 hasConceptScore W4313366343C147483822 @default.
- W4313366343 hasConceptScore W4313366343C188280979 @default.
- W4313366343 hasConceptScore W4313366343C203014093 @default.
- W4313366343 hasConceptScore W4313366343C2777343196 @default.
- W4313366343 hasConceptScore W4313366343C2778220009 @default.
- W4313366343 hasConceptScore W4313366343C55493867 @default.
- W4313366343 hasConceptScore W4313366343C71924100 @default.
- W4313366343 hasConceptScore W4313366343C86803240 @default.
- W4313366343 hasConceptScore W4313366343C8891405 @default.
- W4313366343 hasConceptScore W4313366343C90924648 @default.
- W4313366343 hasIssue "1_Supplement" @default.
- W4313366343 hasLocation W43133663431 @default.
- W4313366343 hasOpenAccess W4313366343 @default.
- W4313366343 hasPrimaryLocation W43133663431 @default.
- W4313366343 hasRelatedWork W2014652871 @default.
- W4313366343 hasRelatedWork W2064609618 @default.
- W4313366343 hasRelatedWork W2170781253 @default.
- W4313366343 hasRelatedWork W2368313480 @default.
- W4313366343 hasRelatedWork W2380686726 @default.
- W4313366343 hasRelatedWork W2390563940 @default.
- W4313366343 hasRelatedWork W2403026982 @default.
- W4313366343 hasRelatedWork W2404360950 @default.
- W4313366343 hasRelatedWork W3029371495 @default.
- W4313366343 hasRelatedWork W4232627510 @default.
- W4313366343 hasVolume "202" @default.
- W4313366343 isParatext "false" @default.
- W4313366343 isRetracted "false" @default.
- W4313366343 workType "article" @default.