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- W4313366350 abstract "Abstract A complex and dynamic regulatory system is needed to fight infection while also preventing induction of inflammatory disease. In macrophages, much is known about how pathogens modulate the innate immune transcriptional response. However, the significance of alternative splicing and manipulation of splicing factors upon infection remains unclear. We have identified several splicing factors that are differentially phosphorylated upon Salmonella Typhimurium bacterial infection, strongly suggesting an important role for RNA processing in the regulation of innate immune responses. A major family of identified phosphorylated splicing factors was the hnRNP (heterogeneous ribonucleoprotein) RNA binding factors, which contribute to multiple aspects of nucleic acid metabolism. Upon LPS stimulation and Salmonella Typhimurium infection, we have found that one of these proteins, hnRNPM, modulates expression of an inflammatory cytokine, IL-6. We have also identified hnRNPM binding sites within the introns of IL-6. We are currently investigating how hnRNPM localizes to chromatin, how hnRNPM intron recognition regulates IL-6 transcript levels, and how the phosphorylation of hnRNPM influences these processes." @default.
- W4313366350 created "2023-01-06" @default.
- W4313366350 creator A5042017097 @default.
- W4313366350 creator A5078749131 @default.
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- W4313366350 date "2018-05-01" @default.
- W4313366350 modified "2023-09-28" @default.
- W4313366350 title "Heterogeneous ribonucleoprotein M influences specific cytokine outcomes upon <i>Salmonella</i> Typhimurium infection" @default.
- W4313366350 doi "https://doi.org/10.4049/jimmunol.200.supp.50.18" @default.
- W4313366350 hasPublicationYear "2018" @default.
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