Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366352> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313366352 endingPage "135.15" @default.
- W4313366352 startingPage "135.15" @default.
- W4313366352 abstract "Abstract The peripheral blood (PB) of cancer patients is frequently neutrophilic and lymphopenic with few studies focused on tissue immunity. In this study we examined eight paired sets of PB and spleen populations to assess the frequency and sub-populations of myeloid derived suppressor- (MDSC) and T-cells. These studies observed a significant decrease in the frequency of granulocytic (G), monocytic (M) and immature MDSC’s in the spleen vs PB (4.8±1.6 vs. 54.4±6.1; 0.2±0.1 vs. 0.9±0.4; and 0.6±0.1 vs. 2.3±0.8 % respectively) but not T-regulatory cells (0.8±0.5 vs. 0.1±0.04 percent). The difference in the G vs M MDSC was consistent with arginase and nitric oxide synthase expression. In contrast, the % of splenic T-cells was increased relative to the PB including CD3+ (35±5 vs. 16±4%), CD4+ (19±2 vs. 10±2%) and CD8+ (10±1 vs. 5±2%). The frequency of transitional memory T-cells (Ttm) was significantly higher in the spleen vs. PB (37.5±6 vs. 26±3.0%) as was the frequency of PD1+CD8+ T-cells (8±2 vs 1±0.5% respectively). The increase in Ttm with their heightened proliferation, effector potential and tumor specific cytotoxicity of PD1+CD8+ cells support the superiority of spleen vs PB cells for adoptive cellular therapy. In support of this both the PD1+ cells were LAG3− and TIM3−, and thus not exhausted. In summary, the spleen cells of cancer patients have an increase in tumor specific effector cells with proliferative potential supporting their utility in therapeutic protocols." @default.
- W4313366352 created "2023-01-06" @default.
- W4313366352 creator A5004120220 @default.
- W4313366352 creator A5018789554 @default.
- W4313366352 creator A5024894397 @default.
- W4313366352 creator A5026061991 @default.
- W4313366352 creator A5089092786 @default.
- W4313366352 date "2019-05-01" @default.
- W4313366352 modified "2023-09-26" @default.
- W4313366352 title "Frequency of Myeloid Derived Suppressor Cells in Spleen and Peripheral Blood from Cancer Patients" @default.
- W4313366352 doi "https://doi.org/10.4049/jimmunol.202.supp.135.15" @default.
- W4313366352 hasPublicationYear "2019" @default.
- W4313366352 type Work @default.
- W4313366352 citedByCount "0" @default.
- W4313366352 crossrefType "journal-article" @default.
- W4313366352 hasAuthorship W4313366352A5004120220 @default.
- W4313366352 hasAuthorship W4313366352A5018789554 @default.
- W4313366352 hasAuthorship W4313366352A5024894397 @default.
- W4313366352 hasAuthorship W4313366352A5026061991 @default.
- W4313366352 hasAuthorship W4313366352A5089092786 @default.
- W4313366352 hasConcept C121608353 @default.
- W4313366352 hasConcept C126322002 @default.
- W4313366352 hasConcept C153911025 @default.
- W4313366352 hasConcept C154317977 @default.
- W4313366352 hasConcept C167672396 @default.
- W4313366352 hasConcept C179185449 @default.
- W4313366352 hasConcept C185592680 @default.
- W4313366352 hasConcept C202751555 @default.
- W4313366352 hasConcept C203014093 @default.
- W4313366352 hasConcept C2779282312 @default.
- W4313366352 hasConcept C2780931953 @default.
- W4313366352 hasConcept C55493867 @default.
- W4313366352 hasConcept C55721878 @default.
- W4313366352 hasConcept C71924100 @default.
- W4313366352 hasConcept C86803240 @default.
- W4313366352 hasConcept C8891405 @default.
- W4313366352 hasConceptScore W4313366352C121608353 @default.
- W4313366352 hasConceptScore W4313366352C126322002 @default.
- W4313366352 hasConceptScore W4313366352C153911025 @default.
- W4313366352 hasConceptScore W4313366352C154317977 @default.
- W4313366352 hasConceptScore W4313366352C167672396 @default.
- W4313366352 hasConceptScore W4313366352C179185449 @default.
- W4313366352 hasConceptScore W4313366352C185592680 @default.
- W4313366352 hasConceptScore W4313366352C202751555 @default.
- W4313366352 hasConceptScore W4313366352C203014093 @default.
- W4313366352 hasConceptScore W4313366352C2779282312 @default.
- W4313366352 hasConceptScore W4313366352C2780931953 @default.
- W4313366352 hasConceptScore W4313366352C55493867 @default.
- W4313366352 hasConceptScore W4313366352C55721878 @default.
- W4313366352 hasConceptScore W4313366352C71924100 @default.
- W4313366352 hasConceptScore W4313366352C86803240 @default.
- W4313366352 hasConceptScore W4313366352C8891405 @default.
- W4313366352 hasIssue "1_Supplement" @default.
- W4313366352 hasLocation W43133663521 @default.
- W4313366352 hasOpenAccess W4313366352 @default.
- W4313366352 hasPrimaryLocation W43133663521 @default.
- W4313366352 hasRelatedWork W1896283254 @default.
- W4313366352 hasRelatedWork W1989111278 @default.
- W4313366352 hasRelatedWork W2001559976 @default.
- W4313366352 hasRelatedWork W2015904992 @default.
- W4313366352 hasRelatedWork W2059306492 @default.
- W4313366352 hasRelatedWork W2363910005 @default.
- W4313366352 hasRelatedWork W2372456458 @default.
- W4313366352 hasRelatedWork W2378253201 @default.
- W4313366352 hasRelatedWork W2382637668 @default.
- W4313366352 hasRelatedWork W3126055100 @default.
- W4313366352 hasVolume "202" @default.
- W4313366352 isParatext "false" @default.
- W4313366352 isRetracted "false" @default.
- W4313366352 workType "article" @default.