Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366372> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313366372 endingPage "71.2" @default.
- W4313366372 startingPage "71.2" @default.
- W4313366372 abstract "Abstract Adoptive T cell therapy in solid tumors such as colorectal cancers are challenging due the low frequency of tumor infiltrating T cells and high molecular tumor heterogeneity. In this study, we are proposing to address this issue by developing a novel technology to expand patient tumor specific T cells ex-vivo, using patient’s matched tumor and PBMCs. Published data from our group shows T cells isolated from heavily treated lymphoma patients when treated with inhibitors of PI3K delta (idelalisib) and vasoactive intestinal peptide (VIPhyb) signaling results in decreased levels of senescent T cells and increased persistence in-vivo in NSG mice. Additionally, we have demonstrated that tumor membrane vesicles (TMVs) prepared from human tumor cells decorated with IL-12 and B7-1 (decorated TMVs), stimulate expansion of tumor antigen specific T cells with increased IFN gamma release. This study thus combines both strategies to obtain tumor antigen specific T cells with enhanced anti-tumor activity and in-vivo persistence. Preliminary data was generated with PBMCs obtained from consented colon cancer patients expanded with decorated TMVs with/without VIPhyb and idelalisib. Results showed that on day 14 of T cell expansion, T cells expanded with decorated TMVs + VIPhyb + idelalisib resulted in significantly increased number of IFN gamma secreting CD8+ T cells (25% of T cells), when compared to T cells treated with decorated TMVs without VIPhyb and idelalisib (13% of T cells). On the other hand, in the absence of decorated TMVs, there were less IFN gamma secreting T cells, both in the CD4 and CD8 compartment. Further experiments are underway to test the persistence and efficacy of the expanded T cells in PDX mice with matched human colon cancer." @default.
- W4313366372 created "2023-01-06" @default.
- W4313366372 creator A5011386306 @default.
- W4313366372 creator A5017926547 @default.
- W4313366372 creator A5041917469 @default.
- W4313366372 creator A5073494284 @default.
- W4313366372 creator A5081310357 @default.
- W4313366372 creator A5085895920 @default.
- W4313366372 creator A5090887063 @default.
- W4313366372 date "2019-05-01" @default.
- W4313366372 modified "2023-09-26" @default.
- W4313366372 title "Improving T cell functionality for adoptive T cell therapy in metastatic colorectal cancer" @default.
- W4313366372 doi "https://doi.org/10.4049/jimmunol.202.supp.71.2" @default.
- W4313366372 hasPublicationYear "2019" @default.
- W4313366372 type Work @default.
- W4313366372 citedByCount "0" @default.
- W4313366372 crossrefType "journal-article" @default.
- W4313366372 hasAuthorship W4313366372A5011386306 @default.
- W4313366372 hasAuthorship W4313366372A5017926547 @default.
- W4313366372 hasAuthorship W4313366372A5041917469 @default.
- W4313366372 hasAuthorship W4313366372A5073494284 @default.
- W4313366372 hasAuthorship W4313366372A5081310357 @default.
- W4313366372 hasAuthorship W4313366372A5085895920 @default.
- W4313366372 hasAuthorship W4313366372A5090887063 @default.
- W4313366372 hasConcept C121608353 @default.
- W4313366372 hasConcept C126322002 @default.
- W4313366372 hasConcept C147483822 @default.
- W4313366372 hasConcept C167672396 @default.
- W4313366372 hasConcept C185592680 @default.
- W4313366372 hasConcept C203014093 @default.
- W4313366372 hasConcept C2776090121 @default.
- W4313366372 hasConcept C2777938653 @default.
- W4313366372 hasConcept C2778461978 @default.
- W4313366372 hasConcept C2779260929 @default.
- W4313366372 hasConcept C2779878957 @default.
- W4313366372 hasConcept C502942594 @default.
- W4313366372 hasConcept C526805850 @default.
- W4313366372 hasConcept C71924100 @default.
- W4313366372 hasConcept C8891405 @default.
- W4313366372 hasConcept C90375314 @default.
- W4313366372 hasConceptScore W4313366372C121608353 @default.
- W4313366372 hasConceptScore W4313366372C126322002 @default.
- W4313366372 hasConceptScore W4313366372C147483822 @default.
- W4313366372 hasConceptScore W4313366372C167672396 @default.
- W4313366372 hasConceptScore W4313366372C185592680 @default.
- W4313366372 hasConceptScore W4313366372C203014093 @default.
- W4313366372 hasConceptScore W4313366372C2776090121 @default.
- W4313366372 hasConceptScore W4313366372C2777938653 @default.
- W4313366372 hasConceptScore W4313366372C2778461978 @default.
- W4313366372 hasConceptScore W4313366372C2779260929 @default.
- W4313366372 hasConceptScore W4313366372C2779878957 @default.
- W4313366372 hasConceptScore W4313366372C502942594 @default.
- W4313366372 hasConceptScore W4313366372C526805850 @default.
- W4313366372 hasConceptScore W4313366372C71924100 @default.
- W4313366372 hasConceptScore W4313366372C8891405 @default.
- W4313366372 hasConceptScore W4313366372C90375314 @default.
- W4313366372 hasIssue "1_Supplement" @default.
- W4313366372 hasLocation W43133663721 @default.
- W4313366372 hasOpenAccess W4313366372 @default.
- W4313366372 hasPrimaryLocation W43133663721 @default.
- W4313366372 hasRelatedWork W1488028176 @default.
- W4313366372 hasRelatedWork W2001055320 @default.
- W4313366372 hasRelatedWork W2031356189 @default.
- W4313366372 hasRelatedWork W2085713490 @default.
- W4313366372 hasRelatedWork W2149871822 @default.
- W4313366372 hasRelatedWork W2220102944 @default.
- W4313366372 hasRelatedWork W2409441623 @default.
- W4313366372 hasRelatedWork W402048087 @default.
- W4313366372 hasRelatedWork W4210976760 @default.
- W4313366372 hasRelatedWork W74037808 @default.
- W4313366372 hasVolume "202" @default.
- W4313366372 isParatext "false" @default.
- W4313366372 isRetracted "false" @default.
- W4313366372 workType "article" @default.