Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366408> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4313366408 endingPage "73.17" @default.
- W4313366408 startingPage "73.17" @default.
- W4313366408 abstract "Abstract Bovine trypanosomiasis is a major drawback for cattle production in sub-Saharan Africa. Immune response to infection is thought to be mediated by genetic diversity in pattern recognition receptors, leading to disease tolerance or susceptibility. We elucidated naturally occurring variations within the bovine CD14 gene promoter in trypanotolerant (N’dama) and trypanosusceptible (White Fulani) cattle, using genomic and transcriptomic methods. We compared our gene sequences with reference bovine genome UMD 3.1 assembly from the Ensembl database. In all, we identified a total of 54 and 41 SNPs at the CD14 promoter for Ndama and White Fulani respectively, including 10 (rs210109064, rs473185091, rs521360374, rs454858160, rs432371570, rs446947915, rs442402639 and rs456854916) common to both. Interestingly, we found 36 SNP’s in 9 SNP regions that were unique to Ndama that were either functional or transcript overlap variants. The significantly higher SNP variation and density at the CD14 promoter region in Ndama could be responsible for its trypanotolerance, potentially an evolutionary adaptation to disease. To further validate this, we examined the expression of CD14 in tissue samples, with our results showing a significant upregulation and higher expression in Ndama compared to White Fulani (p<0.05). These results confirm that trypanotolerant Ndama significantly expressed CD14 and the presence of a higher SNP variation at the CD14 gene promoter plays an important role in pathogen recognition and initiation of immune response, which is absent in White Fulani (trypanosusceptible). This is a major player in host defense mechanism against trypanosomiasis that could be harnessed for breeding and selection purposes." @default.
- W4313366408 created "2023-01-06" @default.
- W4313366408 creator A5036958312 @default.
- W4313366408 creator A5046117488 @default.
- W4313366408 date "2019-05-01" @default.
- W4313366408 modified "2023-09-26" @default.
- W4313366408 title "Disease tolerance and immune response in bovine trypanosomiasis is mediated by CD14 promoter gene" @default.
- W4313366408 doi "https://doi.org/10.4049/jimmunol.202.supp.73.17" @default.
- W4313366408 hasPublicationYear "2019" @default.
- W4313366408 type Work @default.
- W4313366408 citedByCount "0" @default.
- W4313366408 crossrefType "journal-article" @default.
- W4313366408 hasAuthorship W4313366408A5036958312 @default.
- W4313366408 hasAuthorship W4313366408A5046117488 @default.
- W4313366408 hasConcept C104317684 @default.
- W4313366408 hasConcept C135763542 @default.
- W4313366408 hasConcept C139275648 @default.
- W4313366408 hasConcept C153209595 @default.
- W4313366408 hasConcept C203014093 @default.
- W4313366408 hasConcept C2778513237 @default.
- W4313366408 hasConcept C54355233 @default.
- W4313366408 hasConcept C86803240 @default.
- W4313366408 hasConcept C8891405 @default.
- W4313366408 hasConceptScore W4313366408C104317684 @default.
- W4313366408 hasConceptScore W4313366408C135763542 @default.
- W4313366408 hasConceptScore W4313366408C139275648 @default.
- W4313366408 hasConceptScore W4313366408C153209595 @default.
- W4313366408 hasConceptScore W4313366408C203014093 @default.
- W4313366408 hasConceptScore W4313366408C2778513237 @default.
- W4313366408 hasConceptScore W4313366408C54355233 @default.
- W4313366408 hasConceptScore W4313366408C86803240 @default.
- W4313366408 hasConceptScore W4313366408C8891405 @default.
- W4313366408 hasIssue "1_Supplement" @default.
- W4313366408 hasLocation W43133664081 @default.
- W4313366408 hasOpenAccess W4313366408 @default.
- W4313366408 hasPrimaryLocation W43133664081 @default.
- W4313366408 hasRelatedWork W1517693310 @default.
- W4313366408 hasRelatedWork W1984103522 @default.
- W4313366408 hasRelatedWork W2049974637 @default.
- W4313366408 hasRelatedWork W2075926380 @default.
- W4313366408 hasRelatedWork W2107417504 @default.
- W4313366408 hasRelatedWork W2161110446 @default.
- W4313366408 hasRelatedWork W2327017833 @default.
- W4313366408 hasRelatedWork W2360982546 @default.
- W4313366408 hasRelatedWork W2406362019 @default.
- W4313366408 hasRelatedWork W860817473 @default.
- W4313366408 hasVolume "202" @default.
- W4313366408 isParatext "false" @default.
- W4313366408 isRetracted "false" @default.
- W4313366408 workType "article" @default.