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- W4313366424 abstract "Abstract Mucosal immunity influences host-microbial interactions and is evident in the human fetal intestine by 11–14 weeks of gestation; the developing intestine is populated by lymphoid aggregates, memory T cells and dendritic cells capable of responding to microbial stimuli. However, whether intestinal encounters with viable microbes occur in utero and shape immune maturation has not been investigated. Here, we identified subsets of fetal meconium relatively enriched in Lactobacillus or Micrococcaceae, using culture-independent methods, which related to divergent epithelial cell layer transcriptomes and proportions of lamina propria PLZF+ CD161+ CD4+ T cells in paired intestinal samples. Mimicking conditions in the fetal intestine permitted isolation of viable Lactobacillus and Micrococcus strains from fetal meconium. In contrast with phylogenetically related reference strains, fetal isolates utilized placental hormones for growth, remained viable within antigen presenting cells, and exhibited species-specific capacity to promote immune homeostasis. Fetal Lactobacillus isolates reduced activation of antigen presenting cells, while the Micrococcus isolate induced IL-10 production in antigen presenting cells and inhibited IFNγ production by memory PLZF+T cells. Fetal isolates were identified as strains of Lactobacillus jensenii or Micrococcus luteus by whole genome sequencing, with the latter encoding strain-specific genes for intracellular survival, immune modulation, and steroid uptake. These data suggest that pre-natal immunity is influenced by bacterial exposure in the fetal intestine, identifying a previously unknown component of human mucosal immune development." @default.
- W4313366424 created "2023-01-06" @default.
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- W4313366424 date "2019-05-01" @default.
- W4313366424 modified "2023-10-16" @default.
- W4313366424 title "Bacteria in human intestine contribute to mucosal immune function <i>in utero</i>" @default.
- W4313366424 doi "https://doi.org/10.4049/jimmunol.202.supp.191.17" @default.
- W4313366424 hasPublicationYear "2019" @default.
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