Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366479> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313366479 endingPage "190.19" @default.
- W4313366479 startingPage "190.19" @default.
- W4313366479 abstract "Abstract Cerebral malaria (CM) is a deadly neurological complication of Plasmodium falciparum infection resulting in high mortality or severe cognitive deficit. Current therapeutics are highly ineffective, namely due to drug resistance and lack of mechanistic insight into pathophysiology. CM is characterized by VEGF upregulation, disruption of blood-brain barrier (BBB), vascular permeability, and severe edema detectable by MRI. Using small animal MRI and the established animal model of CM Plasmodium berghei ANKA, we recapitulate these features of human disease. Here we show that regions of brain permeability during CM as identified by T1-weighted gadolinium-enhanced and T2-weighted MRI coincide with VEGF mRNA upregulation. Regions of analysis include granular and glomerular cell layers of main olfactory bulb and superior medullary brainstem. We determined through RNA in situ hybridization that neurons are the major cell type responsible for the increased VEGF production during CM. Interestingly, we identified another cell type found to minimally upregulate VEGF in close proximity to these neurons. These VEGF expressing cells may play a role in support or induction of the neuronal response. Intriguingly, astrocytes show no VEGF upregulation during this pathology. Overall, these findings suggest a novel role for neuronal-VEGF in promoting CNS pathology, and a putative mechanism of BBB disruption and vascular permeability during CM." @default.
- W4313366479 created "2023-01-06" @default.
- W4313366479 creator A5009448924 @default.
- W4313366479 creator A5024074311 @default.
- W4313366479 creator A5055605191 @default.
- W4313366479 creator A5069861698 @default.
- W4313366479 creator A5072098114 @default.
- W4313366479 date "2019-05-01" @default.
- W4313366479 modified "2023-09-25" @default.
- W4313366479 title "Upregulation of Neuronal VEGF in Experimental Cerebral Malaria Coincides with Disease Severity Biomarkers in Humans: A Novel Mechanism of Pathophysiology" @default.
- W4313366479 doi "https://doi.org/10.4049/jimmunol.202.supp.190.19" @default.
- W4313366479 hasPublicationYear "2019" @default.
- W4313366479 type Work @default.
- W4313366479 citedByCount "0" @default.
- W4313366479 crossrefType "journal-article" @default.
- W4313366479 hasAuthorship W4313366479A5009448924 @default.
- W4313366479 hasAuthorship W4313366479A5024074311 @default.
- W4313366479 hasAuthorship W4313366479A5055605191 @default.
- W4313366479 hasAuthorship W4313366479A5069861698 @default.
- W4313366479 hasAuthorship W4313366479A5072098114 @default.
- W4313366479 hasConcept C10162356 @default.
- W4313366479 hasConcept C104317684 @default.
- W4313366479 hasConcept C113045295 @default.
- W4313366479 hasConcept C127561419 @default.
- W4313366479 hasConcept C142724271 @default.
- W4313366479 hasConcept C169760540 @default.
- W4313366479 hasConcept C2778048844 @default.
- W4313366479 hasConcept C2778371730 @default.
- W4313366479 hasConcept C2908793570 @default.
- W4313366479 hasConcept C55493867 @default.
- W4313366479 hasConcept C71924100 @default.
- W4313366479 hasConcept C86803240 @default.
- W4313366479 hasConceptScore W4313366479C10162356 @default.
- W4313366479 hasConceptScore W4313366479C104317684 @default.
- W4313366479 hasConceptScore W4313366479C113045295 @default.
- W4313366479 hasConceptScore W4313366479C127561419 @default.
- W4313366479 hasConceptScore W4313366479C142724271 @default.
- W4313366479 hasConceptScore W4313366479C169760540 @default.
- W4313366479 hasConceptScore W4313366479C2778048844 @default.
- W4313366479 hasConceptScore W4313366479C2778371730 @default.
- W4313366479 hasConceptScore W4313366479C2908793570 @default.
- W4313366479 hasConceptScore W4313366479C55493867 @default.
- W4313366479 hasConceptScore W4313366479C71924100 @default.
- W4313366479 hasConceptScore W4313366479C86803240 @default.
- W4313366479 hasIssue "1_Supplement" @default.
- W4313366479 hasLocation W43133664791 @default.
- W4313366479 hasOpenAccess W4313366479 @default.
- W4313366479 hasPrimaryLocation W43133664791 @default.
- W4313366479 hasRelatedWork W2042990852 @default.
- W4313366479 hasRelatedWork W2115140877 @default.
- W4313366479 hasRelatedWork W2164045920 @default.
- W4313366479 hasRelatedWork W2172101099 @default.
- W4313366479 hasRelatedWork W2180211413 @default.
- W4313366479 hasRelatedWork W2238647465 @default.
- W4313366479 hasRelatedWork W2394911427 @default.
- W4313366479 hasRelatedWork W4307770860 @default.
- W4313366479 hasRelatedWork W4313366479 @default.
- W4313366479 hasRelatedWork W62414408 @default.
- W4313366479 hasVolume "202" @default.
- W4313366479 isParatext "false" @default.
- W4313366479 isRetracted "false" @default.
- W4313366479 workType "article" @default.