Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366485> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4313366485 endingPage "50.17" @default.
- W4313366485 startingPage "50.17" @default.
- W4313366485 abstract "Abstract Despite an overall reduction in the global malaria burden, placental malaria (PM) is a major complication of Plasmodium falciparum malaria that impacts hundreds of thousands of pregnancies annually. Primigravid women living in Sub-Saharan Africa are especially prone to PM and often experience poor maternal-fetal health outcomes though pregnancy loss, preterm delivery and infant low birth weight. Mouse models for malaria infection during pregnancy have been instrumental in our current understanding of PM, however our understanding remains incomplete. In the laboratory of Dr. Julie Moore, we have developed a mouse model of infection during pregnancy using the murine-infective species P. chaubaudi chaubaudi AS (PccAS). Infection initiated at gestation day 0 (GD 0) in mice deficient in tumor necrosis factor (TNF) function or signaling and intact C57BL/6J control mice treated with antioxidant and anticoagulant drugs reveals distinct differences in pregnancy outcome at mid-gestation (GD 10). While control mice lose their pregnancies, TNF deficient and drug-treated mice experience rescue of mid-gestational pregnancy and display improved offspring viability at sacrifice. These preliminary findings suggest that by disrupting the function of key host mediators of severe malaria, it may be possible to mitigate negative pregnancy outcomes associated with malaria. Through strategic use of TNF modified mice, combined with studies of gene expression and tissue localization, this work aims to investigate crosstalk between three major host responses to infection - inflammation, coagulation and oxidative stress – and characterize how their interplay may contribute to PM pathogenesis and associated negative pregnancy outcomes." @default.
- W4313366485 created "2023-01-06" @default.
- W4313366485 creator A5000238387 @default.
- W4313366485 creator A5008929177 @default.
- W4313366485 creator A5053498375 @default.
- W4313366485 creator A5058737377 @default.
- W4313366485 creator A5069951105 @default.
- W4313366485 date "2018-05-01" @default.
- W4313366485 modified "2023-09-29" @default.
- W4313366485 title "A potential for crosstalk between inflammation, coagulation and oxidative stress host responses in malaria induced mid-gestational pregnancy loss in a rodent model" @default.
- W4313366485 doi "https://doi.org/10.4049/jimmunol.200.supp.50.17" @default.
- W4313366485 hasPublicationYear "2018" @default.
- W4313366485 type Work @default.
- W4313366485 citedByCount "0" @default.
- W4313366485 crossrefType "journal-article" @default.
- W4313366485 hasAuthorship W4313366485A5000238387 @default.
- W4313366485 hasAuthorship W4313366485A5008929177 @default.
- W4313366485 hasAuthorship W4313366485A5053498375 @default.
- W4313366485 hasAuthorship W4313366485A5058737377 @default.
- W4313366485 hasAuthorship W4313366485A5069951105 @default.
- W4313366485 hasConcept C112672928 @default.
- W4313366485 hasConcept C203014093 @default.
- W4313366485 hasConcept C2776914184 @default.
- W4313366485 hasConcept C2778048844 @default.
- W4313366485 hasConcept C2778371730 @default.
- W4313366485 hasConcept C2779234561 @default.
- W4313366485 hasConcept C42407357 @default.
- W4313366485 hasConcept C46973012 @default.
- W4313366485 hasConcept C54355233 @default.
- W4313366485 hasConcept C71924100 @default.
- W4313366485 hasConcept C86803240 @default.
- W4313366485 hasConceptScore W4313366485C112672928 @default.
- W4313366485 hasConceptScore W4313366485C203014093 @default.
- W4313366485 hasConceptScore W4313366485C2776914184 @default.
- W4313366485 hasConceptScore W4313366485C2778048844 @default.
- W4313366485 hasConceptScore W4313366485C2778371730 @default.
- W4313366485 hasConceptScore W4313366485C2779234561 @default.
- W4313366485 hasConceptScore W4313366485C42407357 @default.
- W4313366485 hasConceptScore W4313366485C46973012 @default.
- W4313366485 hasConceptScore W4313366485C54355233 @default.
- W4313366485 hasConceptScore W4313366485C71924100 @default.
- W4313366485 hasConceptScore W4313366485C86803240 @default.
- W4313366485 hasIssue "1_Supplement" @default.
- W4313366485 hasLocation W43133664851 @default.
- W4313366485 hasOpenAccess W4313366485 @default.
- W4313366485 hasPrimaryLocation W43133664851 @default.
- W4313366485 hasRelatedWork W1489320421 @default.
- W4313366485 hasRelatedWork W1967575964 @default.
- W4313366485 hasRelatedWork W1972381719 @default.
- W4313366485 hasRelatedWork W2107457020 @default.
- W4313366485 hasRelatedWork W2127166169 @default.
- W4313366485 hasRelatedWork W2409471283 @default.
- W4313366485 hasRelatedWork W2425483404 @default.
- W4313366485 hasRelatedWork W2786751313 @default.
- W4313366485 hasRelatedWork W3207156777 @default.
- W4313366485 hasRelatedWork W69335772 @default.
- W4313366485 hasVolume "200" @default.
- W4313366485 isParatext "false" @default.
- W4313366485 isRetracted "false" @default.
- W4313366485 workType "article" @default.