Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366514> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4313366514 endingPage "148" @default.
- W4313366514 startingPage "133" @default.
- W4313366514 abstract "Summary By intradermal testing in normal and immunized animals it has been shown that both the thermolabile and the thermostable toxins of H. pertussis are definitely although weakly antigenic in rabbits but apparently not in human beings. In normal animals, and in a few humans tested, the agglutinogen shows no primary toxicity but in immunized rabbits and human beings an immune response lasting a day or two is obtained. The toxins, on the other hand, produce a primary toxic reaction in normal animals which lasts for one week and longer; the thermolabile toxin (TLT) produces necrosis. In immunized animals the prolonged primary toxic reaction to the toxins is not shown; the reaction appears as a non-necrotic lesion of duration corresponding to the immune response produced by the agglutinogen. The above-mentioned effects were produced in animals immunized slowly and in a prolonged series of injections either by the subcutaneous or intravenous route with either live or formalin-killed whole organisms or sonic extracts. The presence of antitoxin in the sera of the immunized animals was determined by neutralization tests in the skin of normal rabbits. By this procedure no antitoxin could be detected in human hyperimmune or in convalescent sera containing agglutinins. Both toxins were obtained from both phase III and IV and para-pertussis organisms, but in much smaller amounts than from phase I strains. By neutralization tests the toxins from the several phases and in para-pertussis were shown to be related in antigenic specificity. The fallacy of using toxicity as a sole criterion in evaluation of strains suitable for the preparation of vaccines is discussed. The possible use of the various components of H. pertussis as reagents in dermal tests for susceptibility, in diagnosis and as immunizing agents is discussed." @default.
- W4313366514 created "2023-01-06" @default.
- W4313366514 creator A5057547270 @default.
- W4313366514 creator A5083567126 @default.
- W4313366514 creator A5084562877 @default.
- W4313366514 date "1941-10-01" @default.
- W4313366514 modified "2023-09-26" @default.
- W4313366514 title "Studies with H. Pertussis" @default.
- W4313366514 doi "https://doi.org/10.4049/jimmunol.42.2.133" @default.
- W4313366514 hasPublicationYear "1941" @default.
- W4313366514 type Work @default.
- W4313366514 citedByCount "5" @default.
- W4313366514 crossrefType "journal-article" @default.
- W4313366514 hasAuthorship W4313366514A5057547270 @default.
- W4313366514 hasAuthorship W4313366514A5083567126 @default.
- W4313366514 hasAuthorship W4313366514A5084562877 @default.
- W4313366514 hasBestOaLocation W43133665141 @default.
- W4313366514 hasConcept C14086860 @default.
- W4313366514 hasConcept C147483822 @default.
- W4313366514 hasConcept C159047783 @default.
- W4313366514 hasConcept C159654299 @default.
- W4313366514 hasConcept C170493617 @default.
- W4313366514 hasConcept C181199279 @default.
- W4313366514 hasConcept C203014093 @default.
- W4313366514 hasConcept C207545495 @default.
- W4313366514 hasConcept C2777367657 @default.
- W4313366514 hasConcept C2777582894 @default.
- W4313366514 hasConcept C2778973234 @default.
- W4313366514 hasConcept C2779155592 @default.
- W4313366514 hasConcept C2780758401 @default.
- W4313366514 hasConcept C49773422 @default.
- W4313366514 hasConcept C523546767 @default.
- W4313366514 hasConcept C54355233 @default.
- W4313366514 hasConcept C55493867 @default.
- W4313366514 hasConcept C80631254 @default.
- W4313366514 hasConcept C86803240 @default.
- W4313366514 hasConcept C8891405 @default.
- W4313366514 hasConcept C89423630 @default.
- W4313366514 hasConceptScore W4313366514C14086860 @default.
- W4313366514 hasConceptScore W4313366514C147483822 @default.
- W4313366514 hasConceptScore W4313366514C159047783 @default.
- W4313366514 hasConceptScore W4313366514C159654299 @default.
- W4313366514 hasConceptScore W4313366514C170493617 @default.
- W4313366514 hasConceptScore W4313366514C181199279 @default.
- W4313366514 hasConceptScore W4313366514C203014093 @default.
- W4313366514 hasConceptScore W4313366514C207545495 @default.
- W4313366514 hasConceptScore W4313366514C2777367657 @default.
- W4313366514 hasConceptScore W4313366514C2777582894 @default.
- W4313366514 hasConceptScore W4313366514C2778973234 @default.
- W4313366514 hasConceptScore W4313366514C2779155592 @default.
- W4313366514 hasConceptScore W4313366514C2780758401 @default.
- W4313366514 hasConceptScore W4313366514C49773422 @default.
- W4313366514 hasConceptScore W4313366514C523546767 @default.
- W4313366514 hasConceptScore W4313366514C54355233 @default.
- W4313366514 hasConceptScore W4313366514C55493867 @default.
- W4313366514 hasConceptScore W4313366514C80631254 @default.
- W4313366514 hasConceptScore W4313366514C86803240 @default.
- W4313366514 hasConceptScore W4313366514C8891405 @default.
- W4313366514 hasConceptScore W4313366514C89423630 @default.
- W4313366514 hasIssue "2" @default.
- W4313366514 hasLocation W43133665141 @default.
- W4313366514 hasOpenAccess W4313366514 @default.
- W4313366514 hasPrimaryLocation W43133665141 @default.
- W4313366514 hasRelatedWork W1564642963 @default.
- W4313366514 hasRelatedWork W1696096160 @default.
- W4313366514 hasRelatedWork W1828689336 @default.
- W4313366514 hasRelatedWork W1952648054 @default.
- W4313366514 hasRelatedWork W2032038441 @default.
- W4313366514 hasRelatedWork W2132201861 @default.
- W4313366514 hasRelatedWork W2253035484 @default.
- W4313366514 hasRelatedWork W2508073957 @default.
- W4313366514 hasRelatedWork W4313366514 @default.
- W4313366514 hasRelatedWork W2139190225 @default.
- W4313366514 hasVolume "42" @default.
- W4313366514 isParatext "false" @default.
- W4313366514 isRetracted "false" @default.
- W4313366514 workType "article" @default.