Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366688> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W4313366688 endingPage "250" @default.
- W4313366688 startingPage "235" @default.
- W4313366688 abstract "Summary and Conclusions The effect of prolonged hydrolysis by acid and by alkali on the soluble specific substances of pneumococcus types 1, 3, and 8 has been measured by complement-fixation tests with samples taken at frequent intervals, and in types 3 and 8 by antibody-nitrogen determinations also. The initial effect of the acid on types 1 and 3 was an early and rapid increase in activity, in that the hydrolyzed material combined with a larger volume of serum in both reactions. At the same time, a change was indicated in the type of the reaction to one fixing less complement and in which less antibody nitrogen was precipitated per given volume of serum. At the beginning, the effect of the alkali on the type-1 paralleled that of the acid in that a rapid increase occurred in the amount of serum with which the samples reacted. No such rise was evident in the alkaline hydrolysis of type 3. The end results of the acid and alkaline hydrolyses respectively were similar for types 1 and 3; practically complete destruction by acid, and, with the alkali, a stable residual activity equivalent to about 10 per cent of the original. The action of the alkali was more rapid on the type-3 soluble specific substance than on the type-1, while in contrast the action of the acid was slower. The insolubility of the type-3 polysaccharide in the acid undoubtedly influenced the speed of hydrolysis. Type-8 soluble specific substance was attacked so rapidly by both acid and alkali that comparisons with other types, and between the different values for this type were indeterminate. Anticomplementary properties developed on hydrolysis of types 3 and 8 but not type 1, especially by alkali. In these two cases the precipitation of non-antibody nitrogen was particularly noticeable. The latter property was evidenced at a later period than the former. Boiling acid and alkali differ in their effect upon pneumococcus soluble specific substance. The changes that occur appear to be both quantitative and qualitative. In the alkaline hydrolyses quantitative changes predominate." @default.
- W4313366688 created "2023-01-06" @default.
- W4313366688 creator A5011428670 @default.
- W4313366688 creator A5054180984 @default.
- W4313366688 date "1944-10-01" @default.
- W4313366688 modified "2023-10-01" @default.
- W4313366688 title "The Progressive Hydrolysis of Pneumococcus Soluble Specific Substance As Measured by Complement-Fixation and Specific Antibody-Nitrogen Precipitation" @default.
- W4313366688 doi "https://doi.org/10.4049/jimmunol.49.4.235" @default.
- W4313366688 hasPublicationYear "1944" @default.
- W4313366688 type Work @default.
- W4313366688 citedByCount "0" @default.
- W4313366688 crossrefType "journal-article" @default.
- W4313366688 hasAuthorship W4313366688A5011428670 @default.
- W4313366688 hasAuthorship W4313366688A5054180984 @default.
- W4313366688 hasBestOaLocation W43133666881 @default.
- W4313366688 hasConcept C107054158 @default.
- W4313366688 hasConcept C121332964 @default.
- W4313366688 hasConcept C153294291 @default.
- W4313366688 hasConcept C16993767 @default.
- W4313366688 hasConcept C178790620 @default.
- W4313366688 hasConcept C185592680 @default.
- W4313366688 hasConcept C198091228 @default.
- W4313366688 hasConcept C43617362 @default.
- W4313366688 hasConcept C537208039 @default.
- W4313366688 hasConcept C55493867 @default.
- W4313366688 hasConcept C90932021 @default.
- W4313366688 hasConcept C94412978 @default.
- W4313366688 hasConceptScore W4313366688C107054158 @default.
- W4313366688 hasConceptScore W4313366688C121332964 @default.
- W4313366688 hasConceptScore W4313366688C153294291 @default.
- W4313366688 hasConceptScore W4313366688C16993767 @default.
- W4313366688 hasConceptScore W4313366688C178790620 @default.
- W4313366688 hasConceptScore W4313366688C185592680 @default.
- W4313366688 hasConceptScore W4313366688C198091228 @default.
- W4313366688 hasConceptScore W4313366688C43617362 @default.
- W4313366688 hasConceptScore W4313366688C537208039 @default.
- W4313366688 hasConceptScore W4313366688C55493867 @default.
- W4313366688 hasConceptScore W4313366688C90932021 @default.
- W4313366688 hasConceptScore W4313366688C94412978 @default.
- W4313366688 hasIssue "4" @default.
- W4313366688 hasLocation W43133666881 @default.
- W4313366688 hasOpenAccess W4313366688 @default.
- W4313366688 hasPrimaryLocation W43133666881 @default.
- W4313366688 hasRelatedWork W1784523297 @default.
- W4313366688 hasRelatedWork W1990682354 @default.
- W4313366688 hasRelatedWork W2001720702 @default.
- W4313366688 hasRelatedWork W2008744644 @default.
- W4313366688 hasRelatedWork W2065816012 @default.
- W4313366688 hasRelatedWork W2082296951 @default.
- W4313366688 hasRelatedWork W2091337389 @default.
- W4313366688 hasRelatedWork W2326430580 @default.
- W4313366688 hasRelatedWork W2403182174 @default.
- W4313366688 hasRelatedWork W2419210932 @default.
- W4313366688 hasVolume "49" @default.
- W4313366688 isParatext "false" @default.
- W4313366688 isRetracted "false" @default.
- W4313366688 workType "article" @default.