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- W4313367487 abstract "• Pre-clinical head and neck models for identifying mechanisms of resistance to immunotherapy are needed. • This study identifies a critical limitation of PDX models developed from autologously engrafted human stem cells. • Aberrant immune versus tumor response was observed in PDX models generated from autologous patient bone marrow. • Mature patient T cells are necessary in humanized PDX models to correctly reproduce T cell response in pre-clinical models." @default.
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- W4313367487 date "2023-03-01" @default.
- W4313367487 modified "2023-09-29" @default.
- W4313367487 title "Autologous CD34+ stem cell humanization in head and neck cancer modeling: The translational importance of T cell maturation" @default.
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- W4313367487 doi "https://doi.org/10.1016/j.oor.2022.100010" @default.
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