FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313367521> ?p ?o ?g. }

• W4313367521 endingPage "102318" @default.
• W4313367521 startingPage "102318" @default.
• W4313367521 abstract "In recent years, the association between neuroinflammation and opioid dependence has attracted considerable attention. Curcumin, a component of the Curcuma longa, has been shown to act as a suppressor of glial cells and inflammatory cytokines. The main goal of this study was to explore the attenuating effects of curcumin on morphine dependence with a focus on neuroinflammation and μ-opioid receptors in the rat prefrontal cortex. To induce morphine dependence in male Wistar rats, morphine was administered i.p. once daily for 18 days in an escalating dose of 10, 20, and 40 mg/kg. Curcumin (2.5, 5, and 10 mg/kg, i.p.) was given from the days 10th to 18th. Immunofluorescence staining and ELISA methods were used to evaluate glial cells activity and inflammatory cytokines levels, respectively. Western blotting was used to evaluate the expression of μ-opioid receptors. The administration of curcumin (2.5, 5, and 10 mg/kg) for 9 days significantly attenuated the symptoms of morphine withdrawal syndrome. The prefrontal cortex concentration of TNF-α and IL-6 was also reduced by curcumin (2.5, 5, and 10 mg/kg) significantly. Furthermore, curcumin decreased the number of Iba1 and GFAP positive cells in morphine-dependent rats. Moreover, the expression of μ-opioid receptors was significantly reduced by curcumin (10 mg/kg). The results of this study demonstrate that curcumin attenuates morphine dependence in rats through an inhibitory effect on neuroinflammation and a decrease in the expression of μ-opioid receptors in the prefrontal cortex." @default.
• W4313367521 created "2023-01-06" @default.
• W4313367521 creator A5045361619 @default.
• W4313367521 creator A5059475596 @default.
• W4313367521 creator A5069854860 @default.
• W4313367521 creator A5083083365 @default.
• W4313367521 date "2023-04-01" @default.
• W4313367521 modified "2023-09-24" @default.
• W4313367521 title "Curcumin attenuates morphine dependence by modulating μ-opioid receptors and glial cell-activated neuroinflammation in rat" @default.
• W4313367521 cites W1972301631 @default.
• W4313367521 cites W1976194786 @default.
• W4313367521 cites W1983283649 @default.
• W4313367521 cites W1989875371 @default.
• W4313367521 cites W2008523312 @default.
• W4313367521 cites W2011645297 @default.
• W4313367521 cites W2013894801 @default.
• W4313367521 cites W2033431239 @default.
• W4313367521 cites W2036074427 @default.
• W4313367521 cites W2062728888 @default.
• W4313367521 cites W2067911912 @default.
• W4313367521 cites W2069473589 @default.
• W4313367521 cites W2073211159 @default.
• W4313367521 cites W2076006948 @default.
• W4313367521 cites W2078530990 @default.
• W4313367521 cites W2079047325 @default.
• W4313367521 cites W2100825680 @default.
• W4313367521 cites W2111584592 @default.
• W4313367521 cites W2131357228 @default.
• W4313367521 cites W2137689778 @default.
• W4313367521 cites W2138295551 @default.
• W4313367521 cites W2175746191 @default.
• W4313367521 cites W2323356395 @default.
• W4313367521 cites W2412346009 @default.
• W4313367521 cites W2462196007 @default.
• W4313367521 cites W2462345027 @default.
• W4313367521 cites W2473323600 @default.
• W4313367521 cites W2522813771 @default.
• W4313367521 cites W2554844456 @default.
• W4313367521 cites W2555876929 @default.
• W4313367521 cites W2560518779 @default.
• W4313367521 cites W2569553468 @default.
• W4313367521 cites W2574695133 @default.
• W4313367521 cites W2608686430 @default.
• W4313367521 cites W2744974752 @default.
• W4313367521 cites W2783404097 @default.
• W4313367521 cites W2787813232 @default.
• W4313367521 cites W2792758405 @default.
• W4313367521 cites W2794466408 @default.
• W4313367521 cites W2800562546 @default.
• W4313367521 cites W2800626298 @default.
• W4313367521 cites W2891358534 @default.
• W4313367521 cites W2900682399 @default.
• W4313367521 cites W2904767373 @default.
• W4313367521 cites W2914174171 @default.
• W4313367521 cites W2917260877 @default.
• W4313367521 cites W2972040154 @default.
• W4313367521 cites W2991078899 @default.
• W4313367521 cites W3011489203 @default.
• W4313367521 cites W3015101581 @default.
• W4313367521 cites W4251166939 @default.
• W4313367521 cites W4281552425 @default.
• W4313367521 doi "https://doi.org/10.1016/j.npep.2022.102318" @default.
• W4313367521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36640553" @default.
• W4313367521 hasPublicationYear "2023" @default.
• W4313367521 type Work @default.
• W4313367521 citedByCount "1" @default.
• W4313367521 countsByYear W43133675212023 @default.
• W4313367521 crossrefType "journal-article" @default.
• W4313367521 hasAuthorship W4313367521A5045361619 @default.
• W4313367521 hasAuthorship W4313367521A5059475596 @default.
• W4313367521 hasAuthorship W4313367521A5069854860 @default.
• W4313367521 hasAuthorship W4313367521A5083083365 @default.
• W4313367521 hasConcept C126322002 @default.
• W4313367521 hasConcept C14397066 @default.
• W4313367521 hasConcept C169760540 @default.
• W4313367521 hasConcept C169900460 @default.
• W4313367521 hasConcept C170493617 @default.
• W4313367521 hasConcept C185592680 @default.
• W4313367521 hasConcept C2776914184 @default.
• W4313367521 hasConcept C2777389121 @default.
• W4313367521 hasConcept C2778250585 @default.
• W4313367521 hasConcept C2779886867 @default.
• W4313367521 hasConcept C2781063702 @default.
• W4313367521 hasConcept C2781195155 @default.
• W4313367521 hasConcept C55493867 @default.
• W4313367521 hasConcept C71924100 @default.
• W4313367521 hasConcept C86803240 @default.
• W4313367521 hasConcept C87753298 @default.
• W4313367521 hasConcept C98274493 @default.
• W4313367521 hasConceptScore W4313367521C126322002 @default.
• W4313367521 hasConceptScore W4313367521C14397066 @default.
• W4313367521 hasConceptScore W4313367521C169760540 @default.
• W4313367521 hasConceptScore W4313367521C169900460 @default.
• W4313367521 hasConceptScore W4313367521C170493617 @default.
• W4313367521 hasConceptScore W4313367521C185592680 @default.
• W4313367521 hasConceptScore W4313367521C2776914184 @default.
• W4313367521 hasConceptScore W4313367521C2777389121 @default.
• W4313367521 hasConceptScore W4313367521C2778250585 @default.

• next