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• W4313367692 abstract "There is great interest in developing nanoparticle drug delivery systems for the delivery of therapeutics or imaging agents for cancer. In this context, a new radiopharmaceutical was prepared by labeling the methotrexate (MTX) loaded chitosan nanoparticles (CSNPs) with [99mTc]Tc radionuclide, and the breast cancer imaging potential of the radiopharmaceutical was determined by in-vivo biodistribution studies. Within the scope, different amounts of MTX-loaded CSNPs (MTX-CSNPs) (F1–F3) were prepared via an ionotropic gelation process. The physicochemical properties of MTX-CSNPs were evaluated. The mean diameter of MTX-CSNPs was found between 148.8 ± 0.636 nm and 157.0 ± 3.960 nm, the PdI value of between 0.415 ± 0.042 and 0.451 ± 0.036 and the zeta potential of between 15.7 ± 1.17 mV and 18.7 ± 0.27 mV. In addition, the preparation efficiency of MTX-CSNPs was found to be between 64.036 ± 2.054% - 70.234 ± 2.140% and the encapsulation efficiency of CSNPs was found to be between 32.301 ± 1.205–50.304 ± 2.478%. MTX-CSNPs were radiolabeled with [99mTc]Tc, and the radiolabeled nanoparticles ([99mTc]Tc-MTX-CSNPs) were evaluated by both in-vitro cell binding studies and in-vivo biodistribution studies. [99mTc]Tc-MTX-CSNPs showed high labeling efficiency (≥99%) and in-vitro stability up to 6 h at room temperature. According to the cell incorporation study, [99mTc]Tc-MTX-CSNPs (F3) showed significantly higher uptake into 4T1 (breast cancer) cells than R/H-[99mTc]Tc. Biodistribution studies of [99mTc]Tc-MTX-CSNPs (F3) were performed in breast tumor-bearing female Balb/c mice. Compared to [99mTc]Tc-MIBI, [99mTc]Tc-MTX-CSNPs (F3) exhibited significantly higher uptake by breast tumors. This study demonstrates the affinity of [99mTc]Tc-MTX-CSNPs to breast cancer cells and their diagnostic utility." @default.
• W4313367692 created "2023-01-06" @default.
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• W4313367692 date "2023-02-01" @default.
• W4313367692 modified "2023-09-26" @default.
• W4313367692 title "Radiolabeled methotrexate loaded chitosan nanoparticles as imaging probe for breast cancer: Biodistribution in tumor-bearing mice" @default.
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• W4313367692 doi "https://doi.org/10.1016/j.jddst.2022.104146" @default.
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