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- W4313367783 abstract "Uncontrolled bleeding accounts for a significant proportion of early traumatic deaths, and almost always occur within the first six hours of injury. In previous randomised controlled trials (RCTs) of transfusion for injured patients with major bleeding the median time to haemorrhagic death, in trauma systems with rapid transport from injury to hospital was 2-2.6 hours from admission [ [1] Fox EE Holcomb JB Wade CE Bulger EM Tilley BC Group PS. earlier endpoints are required for hemorrhagic shock trials among severely injured patients. Shock. 2017; 47: 567-573 Crossref PubMed Scopus (80) Google Scholar ]. Acute Traumatic Coagulopathy (ATC) occurs within minutes of injury and is evident prior to the arrival of patients in hospital [ [2] Floccard B Rugeri L Faure A et al. Early coagulopathy in trauma patients: an on-scene and hospital admission study. Injury. 2012; 43: 26-32 Abstract Full Text Full Text PDF PubMed Scopus (241) Google Scholar ]. Non-blood component transfusions e.g. crystalloid, do not enable oxygen delivery to the tissues, produce haemodilution of circulating clotting factors, are non-haemostatic, and are harmful to the endothelium. Balanced resuscitation, so called damage control resuscitation which priorities red blood cells with plasma based products has been shown to have restorative effects on the endothelium, ameliorate ATC and improve survival." @default.
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- W4313367783 date "2023-01-01" @default.
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- W4313367783 title "Prehospital blood transfusion: Can we agree on a standardised approach?" @default.
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- W4313367783 doi "https://doi.org/10.1016/j.injury.2022.12.010" @default.
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